Fabrication of microwave-sensitized nanospheres of covalent organic framework with apatinib for tumor therapy

Du, Qijun; Zou, Jian; Huang, Zhongbing; Li, Shimei; Tan, Longfei; Ren, Xiangling; Yin, Guangfu; Yang, Zheng; Meng, Xianwei

doi:10.1016/j.cclet.2022.107763

Cited by 8 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In summary, it was concluded that the response between the detector and the sensor was the interaction between diclazepam and the PTCA-COF, which was the result of selective quenching of the ECL signal of the COF by diclazepam. To the best of our knowledge, the high nitrogen content in COFs provides a large number of lone-pair electrons that can be linked to the loaded drug via π–π bonds, significantly improving their drug loading capacity. Specifically, diclazepam is a π-electron system molecule with a benzene ring (Figure S4), which was conducive to reaction with the π–π conjugated system of Cu 3 (HHTP) 2 /PTCA-COF composites, thereby quenching the ECL properties of the PTCA-COF. , …”

Section: Resultsmentioning

confidence: 99%

Highly Efficient Dual-Color Luminophores for Sensitive and Selective Detection of Diclazepam Based on MOF/COF Bi-Mesoporous Composites

Jiang

Cao

et al. 2023

ACS Sens.

View full text Add to dashboard Cite

Currently, studies on electrochemiluminescence (ECL) mainly focused on the single emission of luminophores while those on multi-color ECL were rarely reported. Here, a bimesoporous composite of the metal−organic framework (MOF)/ covalent-organic framework (COF) with strong and stable dual-color ECL was prepared to construct a novel ECL sensor for sensitive detecting targets. A PTCA-COF with excellent ECL performance was loaded with a great amount of another ECL emitter Cu 3 (HHTP) 2 . Remarkably, the integrated composite had both ECL properties of PTCA-COF at 520 nm and Cu 3 (HHTP) 2 at 600 nm wavelengths. Furthermore, Cu 3 (HHTP) 2 with good electron transfer ability can greatly enhance the electrical conductivity and promote electrochemical activation. Thus, the simultaneous enhanced two-color ECL intensity and the catalytic properties of the conductive MOF exerted a dual enhancement effect on the ECL signal of the composite. Significantly, diclazepam can not only be adsorbed well on the multistage porous structure MOF/COF composite by π−π interactions but also selectively quench the ECL signal of the PTCA-COF, realizing the sensitive detection. The ECL sensor showed a wide detection range from 1.0 × 10 −13 to 1.0 × 10 −8 g/L, and the limit of detection (LOD) was as low as 2.6 × 10 −14 g/L (S/N = 3). The proposed ECL sensor preparation method was simple and sensitive, providing a new perspective for the potential application of multi-color ECL in the sensing field.

show abstract

Section: Resultsmentioning

confidence: 99%

Highly Efficient Dual-Color Luminophores for Sensitive and Selective Detection of Diclazepam Based on MOF/COF Bi-Mesoporous Composites

Jiang

Cao

et al. 2023

ACS Sens.

View full text Add to dashboard Cite

show abstract

“…Therefore, COFs as highly ordered materials offer the advantages of tunable topology and pore size, nearly limitless functionalization capabilities, large surface area, and enduring porosity [6]. These advantages enable the application of COFs in gas storage and separation [7], energy storage [8], sensors [9], catalysis [10], and other applications [11]. Structurally, especially for the widely used two-dimensional (2D) COFs, the ordered layered structure provides a continuous one-dimensional nanoscale channel that allows guest molecules to freely access or interact with the functional sites of Molecules 2024, 29, 1677 2 of 13 the channel wall [12].…”

Section: Introductionmentioning

confidence: 99%

Robust Thiazole-Linked Covalent Organic Frameworks for Water Sensing with High Selectivity and Sensitivity

Wang,

Wu,

et al. 2024

Molecules

View full text Add to dashboard Cite

The rational design of covalent organic frameworks (COFs) with hydrochromic properties is of significant value because of the facile and rapid detection of water in diverse fields. In this report, we present a thiazole-linked COF (TZ-COF-6) sensor with a large surface area, ultrahigh stability, and excellent crystallinity. The sensor was synthesized through a simple three-component reaction involving amine, aldehyde, and sulfur. The thiazole and methoxy groups confer strong basicity to TZ-COF-6 at the nitrogen sites, making them easily protonated reversibly by water. Therefore, TZ-COF-6 displayed color change visible to the naked eye from yellow to red when protonated, along with a red shift in absorption in the ultraviolet-visible diffuse reflectance spectra (UV-vis DRS) when exposed to water. Importantly, the water-sensing process was not affected by polar organic solvents, demonstrating greater selectivity and sensitivity compared to other COF sensors. Therefore, TZ-COF-6 was used to detect trace amounts of water in organic solvents. In strong polar solvents, such as N,N-dimethyl formamide (DMF) and ethanol (EtOH), the limit of detection (LOD) for water was as low as 0.06% and 0.53%, respectively. Even after 8 months of storage and 15 cycles, TZ-COF-6 retained its original crystallinity and detection efficiency, displaying high stability and excellent cycle performance.

show abstract

“…19 Covalent organic frameworks (COF), a new class of crystalline porous materials, have been widely used in the biomedical field because of their advantages of good thermal stability, diverse structures and easy functionalization. [20][21][22][23][24][25][26] Particularly, the extended conjugate structure and highly ordered p-p packing interaction of COFs can prevent ICG performance weakening caused by molecular aggregation, thereby improving the chemical and optical stability of ICG. 14,27 Polydopamine (PDA) polymerized from dopamine under alkaline conditions possesses good biocompatibility and strong NIR absorption, which could be further coupled to a secondary biopolymer by a Michael addition or Schiff base reaction.…”

Section: Introductionmentioning

confidence: 99%

A covalent organic framework-based nanoplatform with enhanced photothermal and photodynamic performance for targeted tumor therapy

Wang,

Xin,

Bai

et al. 2024

Mater. Chem. Front.

View full text Add to dashboard Cite

show abstract

Fabrication of microwave-sensitized nanospheres of covalent organic framework with apatinib for tumor therapy

Cited by 8 publications

References 28 publications

Highly Efficient Dual-Color Luminophores for Sensitive and Selective Detection of Diclazepam Based on MOF/COF Bi-Mesoporous Composites

Highly Efficient Dual-Color Luminophores for Sensitive and Selective Detection of Diclazepam Based on MOF/COF Bi-Mesoporous Composites

Robust Thiazole-Linked Covalent Organic Frameworks for Water Sensing with High Selectivity and Sensitivity

A covalent organic framework-based nanoplatform with enhanced photothermal and photodynamic performance for targeted tumor therapy

Contact Info

Product

Resources

About