Fabrication of novel biological substrate based on photolithographic process for surface enhanced Raman spectroscopy

Zou, Qiang; Mo, Shentong; Pei, Xiaochang; Wang, Yanan; Xue, Tao; Musideke, Mayilamu; Qin, Guoxuan

doi:10.1063/1.5039600

Cited by 8 publications

(7 citation statements)

References 36 publications

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“…The ordered structure of the metal nanoparticle substrate is a prerequisite for SERS enhancement [19][20][21]. Generally speaking, the enhancement reliability of SERS substrates prepared using large-scale equipment such as photolithography [22] or electron beam deposition [23] technology is ordinary. Based on the TiO 2 nanotubes array, Arenas-Hernandez et al constructed TiO 2 nanobowls and nanosheets on the surface of the Ti substrate in an orderly arrangement, on the nanocavities array substrate, by two-step electrochemical anodization.…”

Section: Introductionmentioning

confidence: 99%

Nanoscale flexible Ag grating/AuNPs self-assembly hybrid for ultra-sensitive sensors

et al. 2021

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In this paper, Au nanoparticles (AuNPs) are prepared using wet chemical reduction transfer of dense AuNPs film by self-assembly to the surface of Ag grating, which is inverted from the inner DVD after evaporation. The Ag grating/AuNPs self-assembly hybrid substrate commonly used in surface-enhanced Raman scattering (SERS) research is produced. The coupling effect between AuNP-AuNP and AuNPs-Ag slugs can evidently enhance the local electric field. Experimental results show that the hybrid SERS substrate can detect 10−9 M Rh6G, and the enhancement factor reaches 4.4 × 105. This small, cheap hybrid substrate has enormous potential in the field of SERS sensing.

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Section: Introductionmentioning

confidence: 99%

Nanoscale flexible Ag grating/AuNPs self-assembly hybrid for ultra-sensitive sensors

et al. 2021

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“…In the extended work of SERS investigations, biomolecular detection is very essential for the diagnosis of human diseases. − In the recent years, despite chemical methods, biomolecular detection has been elaborately investigated using AgNPs on pSi substrates. In support of these, Coluccio et al provided a detailed mechanism of cell adhesion and cell interaction with AuNPs/pSi substrate and further explained the chemical mechanisms of cell/surface interaction of AuNPs.…”

Section: Plasmonic Nps Capped Nanocrystalline Porous Siliconmentioning

confidence: 99%

“…In addition to the above stated various wet-chemically processed SiNSs, micro/nano Si nanostructures/patterns are attaining considerable research interests/efforts and extensive development prospects exist in the area of SERS sensing. ,, There are several approaches highlighted in the controlled fabrication of micro/nanostructures through PS deposition with chemical processing, photo/electro lithography, focused ion beam (FIB) techniques, ion beam processing, etc., ,− which result in high sensitivity and reproducibility of the SERS substrates. However, the morphology of SiNSs obtained by these processes is limited to 2D mode, which can reduce the accumulation of high-density hot-spots.…”

Section: Silicon Composed Hybrid Nanostructuresmentioning

confidence: 99%

Silicon Nanostructures for Molecular Sensing: A Review

Vendamani

Rao

Pathak

2022

ACS Appl. Nano Mater.

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This review presents a comprehensive synopsis of the recent developments and achievements in the research of nanosensors composed of plasmonic nanoparticles (NPs) and silicon nanostructures (NSs) for effective trace-level molecular detection. This review focuses intensively on the methodologies for the preparation and enforcement of a variety of SiNSs including (a) metal nanoparticles decorated silicon nanowires (NWs), (b) metal nanodendrites (NDs) on Si substrate, (c) plasmonic NPs decorated nanocrystalline porous silicon (pSi), and (d) silicon composed hybrid nanostructures with favorable parameters of importance in sensing. Furthermore, their potency in wide molecular sensing applications, especially chemical, biological, and explosive molecules based on surface enhanced Raman scattering (SERS) phenomenon is discussed in detail. Various demonstrations and categorizations are provided on the topic of Si-based NSs for a clear understanding to diverse readers. A roadmap is also provided at the end for achieving superior sensing materials or devices in the future.

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“…Compared to colloidal metal substrates, solid substrates are characterized by homogeneity; ease of sample preparation, including surface functionalization and washing steps; and the allowing of the detection of single molecules in a small volume. The formation of solid substrates is carried out by self-assembly [ 97 , 98 , 99 ] or lithography [ 100 , 101 , 102 ] methods or using the combination of these methods, resulting in the creation of substrates with different SPR properties. Table 1 summarizes various approaches to create SERS-active substrates [ 86 , 94 ].…”

Section: Application Of Sers and Sers-combined Raman Techniques In The Detection Of Biomoleculesmentioning

confidence: 99%

Raman Scattering-Based Biosensing: New Prospects and Opportunities

et al. 2021

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The growing interest in the development of new platforms for the application of Raman spectroscopy techniques in biosensor technologies is driven by the potential of these techniques in identifying chemical compounds, as well as structural and functional features of biomolecules. The effect of Raman scattering is a result of inelastic light scattering processes, which lead to the emission of scattered light with a different frequency associated with molecular vibrations of the identified molecule. Spontaneous Raman scattering is usually weak, resulting in complexities with the separation of weak inelastically scattered light and intense Rayleigh scattering. These limitations have led to the development of various techniques for enhancing Raman scattering, including resonance Raman spectroscopy (RRS) and nonlinear Raman spectroscopy (coherent anti-Stokes Raman spectroscopy and stimulated Raman spectroscopy). Furthermore, the discovery of the phenomenon of enhanced Raman scattering near metallic nanostructures gave impetus to the development of the surface-enhanced Raman spectroscopy (SERS) as well as its combination with resonance Raman spectroscopy and nonlinear Raman spectroscopic techniques. The combination of nonlinear and resonant optical effects with metal substrates or nanoparticles can be used to increase speed, spatial resolution, and signal amplification in Raman spectroscopy, making these techniques promising for the analysis and characterization of biological samples. This review provides the main provisions of the listed Raman techniques and the advantages and limitations present when applied to life sciences research. The recent advances in SERS and SERS-combined techniques are summarized, such as SERRS, SE-CARS, and SE-SRS for bioimaging and the biosensing of molecules, which form the basis for potential future applications of these techniques in biosensor technology. In addition, an overview is given of the main tools for success in the development of biosensors based on Raman spectroscopy techniques, which can be achieved by choosing one or a combination of the following approaches: (i) fabrication of a reproducible SERS substrate, (ii) synthesis of the SERS nanotag, and (iii) implementation of new platforms for on-site testing.

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Fabrication of novel biological substrate based on photolithographic process for surface enhanced Raman spectroscopy

Cited by 8 publications

References 36 publications

Nanoscale flexible Ag grating/AuNPs self-assembly hybrid for ultra-sensitive sensors

Nanoscale flexible Ag grating/AuNPs self-assembly hybrid for ultra-sensitive sensors

Silicon Nanostructures for Molecular Sensing: A Review

Raman Scattering-Based Biosensing: New Prospects and Opportunities

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