In this paper, a novel surface-enhanced Raman scattering (SERS) substrate based on Integrated Circuit (IC) process was designed, using photolithography, etching and other processes on the silicon wafer processing. Its surface morphology and Raman activity were characterized and tested. The relationship between the substrate’s photolithographic pattern and its Raman activity, stability and reproducibility has been analyzed and verified, and some suggestions for improvement of processing steps were given. This substrate can be used for the detection of biological proteins and provides a powerful research tool for life science and analytical chemistry research.

A surface-enhanced Raman scattering (SERS) platform for the selective trace analysis of Hg 2+ ions was reported, based on poly-thymine (T) aptamer/2-naphthalenethiol (2-NT)-modified gold nanoparticles (AuNPs), which was an oligonucleotide-functionalized nanosensor and SERS chip. 2-NT was used as a Raman reporter, and T aptamer could form a T-Hg 2+ -T structure with Hg 2+ ions making an SERS nanosensor absorbed to the SERS chip. The optimum concentrations of DNA and 2-NT were obtained. An average of 960 DNA molecules attached to each AuNP were measured. The limit of detection (LOD) was 1.0 ppt (1.0 × 10 -12 g/mL), which is far below the limit of 10.0 ppb for drinking water, stipulated by the World Health Organization. The sensor has the advantages of low detection cost, a simple sample pretreatment, a green solution and reducing false positives. Furthermore, the nanosensor was used for the determination of trace Hg 2+ in the water of a lake; a reliable result was obtained accurately.

In this study, in order to obtain the optimal fabricating condition, the influences of heating temperature and time on the fabrication of zinc oxide (ZnO) nanowires are clarified. During this process, the synthesis and scanning electron microscope (SEM) images of ZnO nanostructures, produced by direct heating of metallic zinc, are presented. Besides, the SEM images and X-ray diffraction (XRD) patterns of products under different conditions are compared to analyze the surface morphology and composition of products. In the final observation, the best diameters of ZnO nanowires are achieved as 60–70 nm, which can be successfully applied as a substrate in Raman measurement. The optimal temperature is 450[Formula: see text]C, as well as the optimal time is 40–50 min.

Abstract. In this paper, a general method of producing zero-dimensional (0-D) and onedimensional (1-D) nano-structures by adjusting only one parameter in the process of production is investigated. To further study the result of small-scale effects, a quantitative characterization for the specific surface area of 1-D nanostructure is proposed. And the characterization method could be integrated into the nano-systems to reflect useful parameters for the analysis of nanomaterials. These two methods mentioned above could enhance nano-fabrication in volume productions, as well as predict the properties of nanodevices in years to come. This means, to some extent, would exert an unquestionably positive impact on manufacturing of nanomaterials and nanodevices.

Abstract. In this paper, a new process for the preparation of one-dimensional ZnO nanomaterials was studied. A single-dimensional ZnO nanowire was synthesized by solidphase grinding method. The SEM images were taken first and then the SEM images of the products were compared in different ways. In order to understand the mechanism of product formation better, the surface morphology and composition of the products were observed. The optimum conditions for the preparation of one-dimensional ZnO nanowires were established, which provided important reference value for the production of nanomaterials. Besides, the solid-phase grinding method, in a large scale, would exert an unquestionably positive impact on manufacturing nanomaterials, as well as render the preparation more effective.