Fabrication of Poly(methyl methacrylate) Microfluidic Chips by Atmospheric Molding

Muck, Alexander; Wang, Joseph; Jacobs, Michael; Chen, Gang; Chatrathi, Madhu Prakash; Jurka, V.; Výborný, Zdeněk; Spillman, Scott D.; Sridharan, Gautham; Schöning, Michael J.

doi:10.1021/ac035030+

Cited by 127 publications

(87 citation statements)

References 25 publications

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“…do Lago and co-workers [87] demonstrated that a low cost electrophoretic microchip for CCD can be fabricated by depositing a thin layer of laser printer toner on a polyester film, which is then laminated with another polyester film of the same dimensions. Muck et al [91] demonstrated a new approach to the fabrication of PMMA-chips to be used with CCD which consists of UV-polymerization of a monomer in contact with a negative master of the desired structures. A range of applications of microchip electrophoresis with CCD has been reported.…”

Section: Contactless Conductivity Detection In Microchip Electrophoresismentioning

confidence: 99%

Contactless Conductivity Detection in Capillary Electrophoresis: A Review

2004

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The popularity of contactless conductivity detection in capillary electrophoresis has been growing steadily over the last few years. Improvements have been made in the design of the detector in order to facilitate its handling, to allow easy incorporation into available instruments or to achieve higher sensitivity. The understanding of its fundamental working principles has been advanced and the detection approach has also been transferred to lab-on-chip devices. The range of applications has been extended greatly from the initial work on small inorganic ions to include organic species and biomolecules. Concurrent determination of cations and anions by dual injection from opposite ends has been demonstrated as well as sample introduction by using flow-injection systems for easy automation of the process.

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Section: Contactless Conductivity Detection In Microchip Electrophoresismentioning

confidence: 99%

Contactless Conductivity Detection in Capillary Electrophoresis: A Review

2004

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“…The channel had trapezoidal shape with 40 mm (bottom) and 100 mm (top) widths and a 50 mm depth. The PMMA microchips were prepared in our laboratory according to a recently reported procedure [21]. Briefly, a silicon master was prepared by pattern transfer techniques including soft lithography and wet chemical etching and used as a negative template to create the desired channel structure.…”

Section: Microchip Fabricationmentioning

confidence: 99%

Screen‐Printed Contactless Conductivity Detector for Microchip Capillary Electrophoresis

et al. 2008

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A new method for mass fabrication of silver ink conductivity detector electrodes for poly(methylmethacrylate) (PMMA) microchip electrophoretic systems has been developed based on screen-printing technology. Printing of silver conductivity electrodes was performed through a patterned stencil on thin PMMA sheets. Following the electrode fabrication, the PMMA sheets are cut into cover sheets, and are aligned and sealed to the channel plate thus establishing a complete microchip separation device. The effects of the electrode width and spacing on the response and resolution have been investigated and the optimized electrode performance was compared to commonly used aluminum electrodes in the determination of ammonium, methyl ammonium, and sodium. The utility of the screenprinted contactless conductivity detector (SPCCD) electrodes is further demonstrated for the separation and detection of organic acids with excellent reproducibility (RSD values of 3.7% and 4.1% for oxalate and tartrate, respectively). The thick-film fabrication of the electrode material demonstrates the ability to mass-fabricate detection devices with total process of device fabrication requiring less than 4 h (including the fabrication of channel plate, cover sheet with the electrodes, and subsequent bonding). The fabrication method described here is convenient and does not compromise the detector performance, hence offers great promise for producing single use field deployable analytical microsystems.

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“…Essa classe de compostos desempenha um papel fundamental no sistema nervoso central atuando como neurotransmissores. Trabalhos que têm como objetivo apresentar novas técnicas de microfabricação ou sistemas de detecção geralmente apresentam separações de catecolaminas como compostos modelos [131][132][133] . A determinação simultânea de dopamina, norepinefrina, L-DOPA, DOPAC e ácido ascórbico em amostras de plasma, foi realizada por Johirul e colaboradores 134 usando eletroforese de zona em microdispositivos construídos em vidro.…”

Section: Análise De Pequenas Moléculasunclassified