Fabrication of polymeric core-shell nanostructures

Akala, Emmanuel O.; Adesina, S. K.

doi:10.1016/b978-0-12-813629-4.00001-2

Cited by 2 publications

(3 citation statements)

References 113 publications

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“…If the selected copolymers have low water solubility, the dissolution of copolymer and drug can be executed in a water-miscible organic solvent, that posteriorly is replaced with deionized water through a semipermeable membrane, inducing micelle formation. The solvent removal is a slow process that often requires up to 36 hours, and the IE and size of the particles are dependent of this phase [ 1 , 9 , 30 ].…”

Section: Polymeric Micelles Physicochemical Characterizationmentioning

confidence: 99%

“…In this micelle preparation technique, a water-immiscible volatile organic solvent, such as chloroform, is added slowly to the aqueous medium, forming an emulsion. This aqueous medium contains the copolymer and drug, and the micelle formation happens after agitation and solvent evaporation [ 1 , 9 , 30 ].…”

Section: Polymeric Micelles Physicochemical Characterizationmentioning

confidence: 99%

“…This method, represented in Figure 3 , consists in dissolving the drug and copolymers in a volatile organic solvent or a mixture, that is afterwards evaporated, forming a thin polymeric film at the recipient’s bottom. The film is then hydrated with water by sonication or stirring [ 1 , 9 , 30 ].…”

Section: Polymeric Micelles Physicochemical Characterizationmentioning

confidence: 99%

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Polymeric Micelles: A Promising Pathway for Dermal Drug Delivery

et al. 2021

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Nanotechnology is an area in great development and with application in the most varied fields of science, including cosmetic and pharmaceutical industries. Because conventional formulations for topical application are not always able to effectively penetrate the physical barrier that human skin exerts against factors and compounds of the external environment, polymeric micelles appear as alternative carriers for drugs and active ingredients delivery, also allowing ingredients with lower solubility and higher lipophilicity to be delivered. In fact, the augmented bioavailability of drugs, greater efficacy even at a lower dose, and selective drug delivery in specific organelles are very interesting advantages of the polymeric micelles usage in cutaneous application. As a consequence, they show a reduction in many of the local and systemic adverse effects, which might lead to an increase in patient compliance to the therapeutics, constituting a promising alternative to conventional topical formulations.

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Section: Polymeric Micelles Physicochemical Characterizationmentioning

confidence: 99%