Fabrication of polymeric microparticles for drug delivery by soft lithography

Guan, Jingjiao; Ferrell, Nicholas; Lee, L. James; Hansford, Derek J.

doi:10.1016/j.biomaterials.2006.03.011

Cited by 102 publications

(81 citation statements)

References 19 publications

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“…Those techniques can also be applied for the preparation of PLGA microparticles. The geometry of a lithographic replication mold can be designed to produce PLGA microparticles with any desired geometry such as trapezoidal-, conical-, bar-, arrow-, square-, rectangular-, or cross-shaped particles [24]. The so-called hydrogel template method proposed by Acharya et al is an example of imprint lithographic replication techniques [25,26].…”

Section: Plga Microparticles With Any Geometrical Microfeaturementioning

confidence: 99%

Innovative next-generation PLGA microparticles with multifunctional architecture

Sah¹,

Sah²

2017

Biodegradable Polymers: Recent Developments and New Perspectives

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Section: Plga Microparticles With Any Geometrical Microfeaturementioning

confidence: 99%

Innovative next-generation PLGA microparticles with multifunctional architecture

Sah¹,

Sah²

2017

Biodegradable Polymers: Recent Developments and New Perspectives

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“…Also detected was a peak at 1724 cm´1, which is attributed to C=O stretching vibrations related to the aromatic acid esters, such as terephthalic esters [16,22]. The presence of terephthalic esters on the PbMs spectrum is evidence of the cross-linking reaction between xylan and TC, which is the reason for the polymeric membrane stabilization since no other known approach for cross-linking, such as heating, pressure, or UV light exposure, was used to reinforce the polymer chains [23].…”

Section: Ft-ir Spectroscopymentioning

confidence: 99%

Leads from Physical, Chemical, and Thermal Characterization on Cytotoxic Effects of Xylan-Based Microparticles

et al. 2015

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Interfacial cross-linking (ICL) has been considered a feasible technique to produce polysaccharide-based microparticles (PbMs), even though only a few studies have been concerned with their biocompatibility. In this work, PbMs were prepared by the ICL method and characterized in regard to their in vitro biocompatibility, chemical linkages, and physical and thermal properties. First, the cell viability assay revealed that PbMs toxicity was concentration-dependent. Then, it was observed that the toxicity may be related to the way in which the binding occurred, and not exclusively to the stoichiometry between the polymer and the cross-linking agent. Moreover, the PbMs biosafety was predicted by the use of physicochemical procedures, which were able to identify unbound cross-linking agent residues and also to reveal the improvement of their thermal stability. Accordingly, this work suggests a step-by-step physicochemical procedure able to predict potential toxicity from micro-structured devices produced by polysaccharides. Likewise, the use of PbMs as a drug carrier should be cautiously considered.

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“…For example, patterned and releasable polymeric microparticles were fabricated for drug delivery applications and as platforms for the construction of multi-functional drug delivery devices by Guan et al (2005Guan et al ( , 2006. Most of these methods are gaining much importance in the biomedical fabrication field, for their versatility in achieving specific shapes of hydrogels at the micro-and nanoscale.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of hydrogel microstructures using polymerization controlled by microcontact printing (PCμCP)

Biswal

Chirra

Hilt

2007

Biomed Microdevices

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Hydrogels are widely applied as functional biomaterials in the diagnostic and therapeutic fields. For example, intelligent hydrogels containing ionic groups (pH responsive) and poly(ethylene glycol) have promising applications as pH responsive materials in the biomedical and pharmaceutical fields. For potential use of hydrogels in micro- and nano devices, methods are needed to fabricate structures of various geometries at the micro- and nano scale. In this work, polymerization controlled by microcontact printing (PCmicroCP) is utilized, which is a method that uses microcontact printing to spatially define polymerization zones. Specifically, gold surfaces were modified by a hydrophobic thiol self assembled monolayer via microcontact printing and then a hydrophilic prepolymer solution was applied and only spatially occupied the regions confined by the hydrophobic thiol. Subsequently, polymerization reactions were carried out to create hydrogel microstructures. The patterned hydrogel produced using these methods are highly uniform in size and shape, having potential application in the field of biomedical microdevices.

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Fabrication of polymeric microparticles for drug delivery by soft lithography

Cited by 102 publications

References 19 publications

Innovative next-generation PLGA microparticles with multifunctional architecture

Innovative next-generation PLGA microparticles with multifunctional architecture

Leads from Physical, Chemical, and Thermal Characterization on Cytotoxic Effects of Xylan-Based Microparticles

Fabrication of hydrogel microstructures using polymerization controlled by microcontact printing (PCμCP)

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