Fabrication of silver-grafted silica nanohybrids via aminosilane-inspired surface functionalization for enhanced electrochemical performance towards gastric cancer biomarker

Bhattacharjee, Sangya; Subha, P. V.; Das, Merina Paul; Munuswamy-Ramanujam, Ganesh; Shim, Yoon‐Bo; Neppolian, Bernaurdshaw; Das, Jayabrata

doi:10.1016/j.apsusc.2020.148517

Cited by 9 publications

(7 citation statements)

References 57 publications

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“…Considering the gradient of 0.054, the value of α n is estimated to be 1.095. Given the electrochemical oxidation of MTH involves the transfer of 2 electrons ( n = 2), the value of α is found to be 0.547, which correlates well between 0.3 and 0.7, as reported elsewhere . The value of the standard heterogeneous rate constant ( k s ) ca.…”

Section: Resultssupporting

confidence: 79%

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Electropotential-Inspired Star-Shaped Gold Nanoconfined Multiwalled Carbon Nanotubes: A Proof-of-Concept Electrosensoring Interface for Lung Metastasis Biomarkers

Bhattacharjee

George

Shim

et al. 2022

ACS Appl. Bio Mater.

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Herein, an innovative way of designing a star-shaped gold nanoconfined multiwalled carbon nanotube-engineered sensoring interface (AuNS@MWCNT//GCE) is demonstrated for quantification of methionine (MTH); a proof of concept for lung metastasis. The customization of the AuNS@MWCNT is assisted by surface electrochemistry and thoroughly discussed using state-of-the-art analytical advances. Micrograph analysis proves the protrusion of nanotips on the surface of potentiostatically synthesized AuNPs and validates the hypothesis of Turkevich seed (AuNP)-mediated formation of AuNSs. In addition, a facile synthesis of electropotential-assisted transformation of MWCNTs to luminescent nitrogen-doped graphene quantum dots (N d -GQDs avg. ∼4.3 nm) is unveiled. The sensor elucidates two dynamic responses as a function of C MTH ranging from 2 to 250 μM and from 250 to 3000 μM with a detection limit (DL) of ∼0.20 μM, and is robust to interferents except for tiny response of a similar −SH group bearing Cys (<9.00%). The high sensitivity (0.44 μA•μM −1 • cm −2 ) and selectivity of the sensor can be attributed to the strong hybridization of the Au nanoparticle with the sp 2 C atom of the MWCNTs, which makes them a powerful electron acceptor for Au−SH−MTH interaction as evidenced by density functional theory (DFT) calculations. The validation of the acceptable recovery of MTH in real serum and pharma samples by standard McCarthy− Sullivan assay reveals the holding of great promise to provide valuable information for early diagnosis as well as assessing the therapeutic consequence of lung metastasis.

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Section: Resultssupporting

confidence: 79%

“…Given the electrochemical oxidation of MTH involves the transfer of 2 electrons (n = 2), the value of α is found to be 0.547, which correlates well between 0.3 and 0.7, as reported elsewhere. 58 The value of the standard heterogeneous rate constant (k s ) ca. 4.26 × 10 −3 s −1 is estimated from the intercept of eq 11.…”

Section: Hauclmentioning

confidence: 99%

Electropotential-Inspired Star-Shaped Gold Nanoconfined Multiwalled Carbon Nanotubes: A Proof-of-Concept Electrosensoring Interface for Lung Metastasis Biomarkers

Bhattacharjee

George

Shim

et al. 2022

ACS Appl. Bio Mater.

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“… where α represents the electron-transfer coefficient. The enhanced active surface area (τ aq ) available at the proposed erGO/TiS 2 //GCE for the oxidation reaction of AA is calculated using the following equation (eq ) and estimated to be ∼9.2 × 10 –9 mol·cm 2 , where Q , F , n , and A stand for integrated charge of the anodic peak (ν = 0.05 V·s –1 ), the Faraday constant (96 485.3 C·mol –1 ), the number of transferred electrons (two in the case of AA), and the working area of the electrode (cm 2 ), respectively . In addition, the effect of the logarithm of the scan rate (log ν) vs the peak potential ( E pa ) is studied.…”

Section: Resultsmentioning

confidence: 99%

“…and estimated to be ∼9.2 × 10 −9 mol•cm 2 , where Q, F, n, and A stand for integrated charge of the anodic peak (ν = 0.05 V•s −1 ), the Faraday constant (96 485.3 C•mol −1 ), the number of transferred electrons (two in the case of AA), and the working area of the electrode (cm 2 ), respectively. 56 In addition, the effect of the logarithm of the scan rate (log ν) vs the peak potential (E pa ) is studied. From Figure 5c, it can be observed that the peak potentials grow gradually on increasing the scan rate and establish two linear dependence relations above the scan rate of 0.12 V•s −1 .…”

Section: Consequences Of Scan Ratementioning

confidence: 99%

Design of Electrochemically Reduced Graphene Oxide/Titanium Disulfide Nanocomposite Sensor for Selective Determination of Ascorbic Acid

Pal

Bhattacharjee

Das

et al. 2021

ACS Appl. Nano Mater.

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Synthesizing conductive nanocomposites (NCs) for realizing an ultrasensitive biosensor is a prevalent technological thrust. Herein, a simple and unusual design of a sensing platform is documented using electrochemically reduced graphene oxide/titanium disulfide nanocomposite (erGO/TiS 2 NC) for detection of ascorbic acid (AA): a significant neurobiological molecule. The NC is designed via sonolysis of a solution comprising ex situsynthesized GO and TiS 2 and subsequently electrochemically reduced for fabricating the sensing interface. Advanced analytical studies are carried out to support the construction of the erGO/TiS 2 //glassy carbon electrode (GCE). Under the optimal measuring conditions, the sensor offers two linear responses within (i) 0.1 → 1 μM, a limit of detection (LoD) of 30.2 nM (S/N = 3) and a sensitivity of 0.34 μA•μM −1 •cm −2 , and (ii) 1 → 400 μM, a LoD of 91.4 nM and a sensitivity of 0.11 μA•μM −1 •cm −2 for AA. Moreover, the sensor demonstrates high selectivity toward AA over other bioanalytes except for tiny anodic responses of cysteine (7.5%) and dopamine (8.9%). Finally, the practicability of the proposed sensor has been tested for AA in pharmaceutical and human urine samples and validated by high-performance liquid chromatography-mass spectrometry (HPLC-MS). Overall, the sensor demonstrates satisfactory reliability for recovery of AA and can be considered for the diagnosis of clinical samples.

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“…A variety of materials such as metallic nanoparticles, 36,37 graphene Oxide (GO), 38 silica nanoparticles, 39 quantum dots 40 or metal-organic frameworks, 41,42 have been used as platforms for the design of biosensors. Among them, MOFs with specific functional sites have sparked a lot of interest because of their diverse structures and multifunctionalities, allowing for specific molecular recognition and fluorescence generation and/or change.…”

Section: Biosensing and Bioimagingmentioning

confidence: 99%

Metal–organic frameworks towards bio-medical applications

Lepoitevin

Serre

2021

Mater. Chem. Front.

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Fabrication of silver-grafted silica nanohybrids via aminosilane-inspired surface functionalization for enhanced electrochemical performance towards gastric cancer biomarker

Cited by 9 publications

References 57 publications

Electropotential-Inspired Star-Shaped Gold Nanoconfined Multiwalled Carbon Nanotubes: A Proof-of-Concept Electrosensoring Interface for Lung Metastasis Biomarkers

Electropotential-Inspired Star-Shaped Gold Nanoconfined Multiwalled Carbon Nanotubes: A Proof-of-Concept Electrosensoring Interface for Lung Metastasis Biomarkers

Design of Electrochemically Reduced Graphene Oxide/Titanium Disulfide Nanocomposite Sensor for Selective Determination of Ascorbic Acid

Metal–organic frameworks towards bio-medical applications

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