Fabrication of whole-thermoplastic normally closed microvalve, micro check valve, and micropump

Pourmand, Adel; Shaegh, Seyed Ali Mousavi; Ghavifekr, Habib Badri; Aghdam, Esmaiel Najafi; Dokmeci, Mehmet R.; Khademhosseini, Ali; Zhang, Yu Shrike

doi:10.1016/j.snb.2017.12.132

Cited by 64 publications

(30 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Generally, poly(dimethylsiloxane) (PDMS) is the most commonly used membrane material due to its good optical transparency and high elasticity for large deformations [10]. Other materials, such as thermal plastic polymer [11,12], shape memory alloy [13,14], glass [15], and more are also used in certain situations. As for the deflection of the membrane, various mechanical [16,17], electrostatic [18,19], pneumatic [20,21], magnetic [22,23], piezoelectric [24], or thermal [25] mechanisms have been proposed.…”

Section: Introductionmentioning

confidence: 99%

“…An active valve with pneumatic actuation usually employs off-chip apparatus such as an air-compressor, a pressure regulator, etc., and does the required flow regulation by the regulation of the air pressure. The valve can be combined to form complex microfluidic devices, such as peristaltic pumps [11,19] and mixers [26]. However, when a low-cost and portable microfluidic system such as in POCT applications requires totally on-chip activation, the active technology may be considered excessive.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Microfluidic Passive Valve with Ultra-Low Threshold Pressure for High-Throughput Liquid Delivery

Zhang

Oseyemi

2019

Micromachines

View full text Add to dashboard Cite

The microvalve for accurate flow control under low fluidic pressure is vital in cost-effective and miniaturized microfluidic devices. This paper proposes a novel microfluidic passive valve comprising of a liquid chamber, an elastic membrane, and an ellipsoidal control chamber, which actualizes a high flow rate control under an ultra-low threshold pressure. A prototype of the microvalve was fabricated by 3D printing and UV laser-cutting technologies and was tested under static and time-dependent pressure conditions. The prototype microvalve showed a nearly constant flow rate of 4.03 mL/min, with a variation of ~4.22% under the inlet liquid pressures varied from 6 kPa to 12 kPa. In addition, the microvalve could stabilize the flow rate of liquid under the time-varying sinusoidal pressures or the square wave pressures. To validate the functionality of the microvalve, the prototype microvalve was applied in a gas-driven flow system which employed an air blower or human mouth blowing as the low-cost gas source. The microvalve was demonstrated to successfully regulate the steady flow delivery in the system under the low driving pressures produced by the above gas sources. We believe that this new microfluidic passive valve will be suitable for controlling fluid flow in portable microfluidic devices or systems of wider applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microfluidic Passive Valve with Ultra-Low Threshold Pressure for High-Throughput Liquid Delivery

Zhang

Oseyemi

2019

Micromachines

View full text Add to dashboard Cite

show abstract

“…A number of reviews has described thermoplastic microfabrication methods [ 7 , 8 , 9 , 10 , 11 , 12 , 13 ], and recent work [ 14 ] discussed the transition from glass and silicon to thermoplastics, while discussing the available fabrication methods for these materials, methods that are often far faster and less expensive. As recently surveyed [ 15 , 16 ], a wide range of demonstrations has developed the use of thermoplastic substrates especially (e.g., [ 17 ] and the references within) in integrations of PDMS with thermoplastics such as poly(methyl methacrylate) (PMMA) and using methods such as plasma activated bonding and hot embossing. Very low cost fabrication methods have been emphasised for such membrane-based chips, for example the recent work [ 18 ] that thermally bonded layers of a variety of polymers to form microvalves.…”

Section: Introductionmentioning

confidence: 99%

“…Recent reports [ 15 , 16 ] demonstrated a very effective way of rapidly fabricating diaphragm-based PMMA and thermoplastic polyurethane (TPU) microfluidics. Rather than use cleanroom-based photolithography in a complex process (typically several days or more), these recent reports used a CO

laser to pattern thermoplastics, forming arbitrarily complex microfluidics within about a day and without cleanroom equipment.…”

Section: Introductionmentioning

confidence: 99%

“…Although this has been used to advantage by, for instance, allowing oxygen exchange through a relatively permeable TPU membrane [ 15 ], this heterogeneity can lead to undesired variations in biological and chemical compatibility, zeta potential, contamination and reagent loss due to permeability. In addition, the placement of the diaphragm material may also require manual intervention, whether to precisely position the diaphragm itself, or to do so for a localised layer of another material in order to ensure that the diaphragm is able to release from the surface (e.g., the manually-placed spot of a marker pen at each valve [ 16 , 54 , 55 ]). Ideally, one would have the ability to minimise the amount of heterogeneity and maximise the choice of potential materials while not requiring any device-level manual intervention for the placement of the release layer.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

CO2 Laser-Based Rapid Prototyping of Micropumps

Strike

Ghofrani²,

Backhouse

2018

Micromachines

View full text Add to dashboard Cite

The fabrication of microdevices for fluidic control often requires the use of flexible diaphragms in a way that requires cleanroom equipment and compromises performance. We use a CO2 laser to perform the standard ablative techniques of cutting and engraving materials, but we also apply a method that we call laser placement. This allows us to fabricate precisely-positioned and precisely-sized, isolated diaphragms. This in turn enables the rapid prototyping of integrated multilayer microfluidic devices to form complex structures without the need for manual positioning or cleanroom equipment. The fabrication process is also remarkably rapid and capable of being scaled to manufacturing levels of production. We explore the use of these devices to construct a compact system of peristaltic pumps that can form water in oil droplets without the use of the non-pulsatile pumping systems typically required. Many devices can be fabricated at a time on a sheet by sheet basis with a fabrication process that, to our knowledge, is the fastest reported to date for devices of this type (requiring only 3 h). Moreover, this system is unusually compact and self-contained.

show abstract

Patient‐Specific Organoid and Organ‐on‐a‐Chip: 3D Cell‐Culture Meets 3D Printing and Numerical Simulation

et al. 2021

View full text Add to dashboard Cite

The last few decades have witnessed diversified in vitro models to recapitulate the architecture and function of living organs or tissues and contribute immensely to advances in life science. Two novel 3D cell culture models: 1) Organoid, promoted mainly by the developments of stem cell biology and 2) Organ‐on‐a‐chip, enhanced primarily due to microfluidic technology, have emerged as two promising approaches to advance the understanding of basic biological principles and clinical treatments. This review describes the comparable distinct differences between these two models and provides more insights into their complementarity and integration to recognize their merits and limitations for applicable fields. The convergence of the two approaches to produce multi‐organoid‐on‐a‐chip or human organoid‐on‐a‐chip is emerging as a new approach for building 3D models with higher physiological relevance. Furthermore, rapid advancements in 3D printing and numerical simulations, which facilitate the design, manufacture, and results‐translation of 3D cell culture models, can also serve as novel tools to promote the development and propagation of organoid and organ‐on‐a‐chip systems. Current technological challenges and limitations, as well as expert recommendations and future solutions to address the promising combinations by incorporating organoids, organ‐on‐a‐chip, 3D printing, and numerical simulation, are also summarized.

show abstract

Fabrication of whole-thermoplastic normally closed microvalve, micro check valve, and micropump

Cited by 64 publications

References 75 publications

Microfluidic Passive Valve with Ultra-Low Threshold Pressure for High-Throughput Liquid Delivery

Microfluidic Passive Valve with Ultra-Low Threshold Pressure for High-Throughput Liquid Delivery

CO2 Laser-Based Rapid Prototyping of Micropumps

Patient‐Specific Organoid and Organ‐on‐a‐Chip: 3D Cell‐Culture Meets 3D Printing and Numerical Simulation

Contact Info

Product

Resources

About