Fabrication, properties and bioapplications of cellulose/collagen hydrolysate composite films

Hydrogel-Based Controlled Release Formulations: Designing Considerations, Characterization Techniques and Applications

“…The polymers used for the fabrication of the hydrogels may either be of synthetic (e.g., polyacrylic acid, polymethacrylic acid and polyhydroxyethyl methacrylic acid) or natural origin (e.g., gelatin, lignin, collagen, cellulose, starch and chitosan) [12][13][14][15][16][17][18] . The application of hydrogels in controlled release of bioactive agents has gained momentum in the last decade.…”

Collagen Networks Obtained by Leather Industry By-Products

“…Due to these remarcable properties, it has been used in various applications, including as a natural fertilizer in agriculture due to the release of free amino acids with a considerable nitrogen content (Niculescu and Gaidau, 2014;Pei et al, 2013). Other applications of collagen hydrolyates are in regenerative medicine, in pharmaceutics, in cosmetics, as a food additive and as a biodegradable packing material (Pei et al, 2013). Unlike gelatin, collagen hydrolyates displays a lower molecular weight and better biodegradability and absorbency (Pei et al, 2013).…”

“…Collagen hydrolysate is a polypeptide compound made by further hydrolysis of collagen, which displays the ability to form thin films on different surfaces, has a hydrophilic character and is not dangerous for human health. Due to these remarcable properties, it has been used in various applications, including as a natural fertilizer in agriculture due to the release of free amino acids with a considerable nitrogen content (Niculescu and Gaidau, 2014;Pei et al, 2013). Other applications of collagen hydrolyates are in regenerative medicine, in pharmaceutics, in cosmetics, as a food additive and as a biodegradable packing material (Pei et al, 2013).…”

“…Other applications of collagen hydrolyates are in regenerative medicine, in pharmaceutics, in cosmetics, as a food additive and as a biodegradable packing material (Pei et al, 2013). Unlike gelatin, collagen hydrolyates displays a lower molecular weight and better biodegradability and absorbency (Pei et al, 2013). The mechanical and thermal stability of the collagen physical hydrogels can be further improved by employing various cross-linking agents, such as: formaldehyde (Zhang et al, 2014;Tan et al, 2015), glutaraldehyde (Zhang et al, 2014;Osborne et al, 1997;Tan et al, 2015;Rault et al, 1996), glycosaminoglycan (Osborne et al, 1997), chondroitin-6-sulphate (Osborne et al, 1997), 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (Osborne et al, 1997;Sionkowska et al, 2010, Rault et al, 1996, 1,1-carbonyldiimidazole (Osborne et al, 1997), hexamethylene diisocyanate (Zhang et al, 2014;Rault et al, 1996), cyanamide (Rault et al, 1996), Nhydroxysuccinimide (Sionkowska et al, 2010;Tan et al, 2015), diepoxypropylether (Sionkowska et al, 2010), hydrazine (Rault et al, 1996), diphenylphosphorylazide (Rault et al, 1996), dialdehyde carboxymethyl cellulose (Tan et al, 2015) and genipin (Zhang et al, 2014;Biswal et al, 2016).…”

“…In order to overcome this disadvantages, the collagen hydrogels were additivated with various compounds, such as cellulose (Pei et al, 2013), glycerol or poly(ethylene glycols) of different molecular weights (Langmaier et al, 2008).…”