Facile construction of fluorescent traceable prodrug nanosponges for tumor intracellular pH/hypoxia dual-triggered drug delivery

Exploring novel strategies to improve anti-tumour efficiency: The potential for targeting reactive oxygen species

“…The suggested doxorubicin conjugated carbon quantum dots-based nanosponges displayed good acid/glutathione binary-triggered medicine discharge because of the binary triggered breakdown within the tumour. The combined medication was consequently liberated with an improved selective inhibition of tumour cell proliferation when compared to free doxorubicin [ 106 ].…”

Nanosponges: An overlooked promising strategy to combat SARS-CoV-2

“…Limitations to the efficacy and delivery of drugs, and their associated adverse effects, have led researchers to move toward nanocarriers with unique properties, optimal effectiveness, specificity, and fewer adverse effects; an effective solution being to deploy nanostructures to effectively transport antiviral drugs or other formulations. [25] , [26] In this context, nanosponges have shown several advantages, such as biocompatibility, porosity, biomimetic features, sustained release behavior, and therapeutic activity (e.g., antimicrobial action against pathogenic bacteria), which make them suitable candidates for improving the bioavailability, stability, and solubility of therapeutic agents or drugs to provide the desired pharmacokinetics (PK) effects 27–29 ; nanosponges can generate a variety of complexes with hydrophilic or lipophilic molecules, improving their transferring and protecting them from degradability. [30] , [31] , [32] For instance, β -cyclodextrin nanosponge-based delivery systems 33 were designed to formulate lipophilic drugs (e.g., dexibuprofen), offering an alternative strategy for enhancing the solubility of these drugs and improving their oral administration.…”

In vitro Antitumor Properties of Fucoidan-Coated, Doxorubicin-Loaded, Mesoporous Polydopamine Nanoparticles

“…This extrapolation can be verified using in vitro drug release models. For example, Li et al examined the drug release behavior of nano-sponges in solutions containing GSH at pH = 5.0 and 7.4 [ 22 ].…”