Facile Fabrication of 3D-Printed Porous Ti6Al4V Scaffolds with a Sr-CaP Coating for Bone Regeneration

Su, Shenghui; Chen, Weidong; Zheng, Minghui; Lu, Guozan; Tang, Wei; Huang, Haihong; Qu, Dongbin

doi:10.1021/acsomega.1c05908

Cited by 15 publications

(5 citation statements)

References 61 publications

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“…Ti-Sr bound nanotubes can effectively inhibit osteoclast differentiation by inhibiting NF-κB and Akt/NFATc1 pathways, as well as negatively regulating the ERK pathway in vivo and in vitro [ 109 ]. Sr-composited Ti implants accelerated bone healing [ 110 ] and significantly raised macrophage phenotype and anti-inflammatory factor production to enhance bone integration [ 111 ]. Ding et al [ 112 ] prepared protein supramolecular nanofilm (Ti-Ly-Sr) composited with Sr on Ti, cell morphology observation, cell activity assay, ALP staining, and quantitative analysis showed that Ti-Ly-Sr enhanced the early adhesion, proliferation, and osteogenic differentiation of BMSCs, increased the expression of BMSC-related osteogenic genes such as BMP-2, OPG, Runx2, and COL1.…”

Section: Biomaterials Compound With Srmentioning

confidence: 99%

Recent Advance of Strontium Functionalized in Biomaterials for Bone Regeneration

et al. 2023

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Bone defect disease causes damage to people’s lives and property, and how to effectively promote bone regeneration is still a big clinical challenge. Most of the current repair methods focus on filling the defects, which has a poor effect on bone regeneration. Therefore, how to effectively promote bone regeneration while repairing the defects at the same time has become a challenge for clinicians and researchers. Strontium (Sr) is a trace element required by the human body, which mainly exists in human bones. Due to its unique dual properties of promoting the proliferation and differentiation of osteoblasts and inhibiting osteoclast activity, it has attracted extensive research on bone defect repair in recent years. With the deep development of research, the mechanisms of Sr in the process of bone regeneration in the human body have been clarified, and the effects of Sr on osteoblasts, osteoclasts, mesenchymal stem cells (MSCs), and the inflammatory microenvironment in the process of bone regeneration have been widely recognized. Based on the development of technology such as bioengineering, it is possible that Sr can be better loaded onto biomaterials. Even though the clinical application of Sr is currently limited and relevant clinical research still needs to be developed, Sr-composited bone tissue engineering biomaterials have achieved satisfactory results in vitro and in vivo studies. The Sr compound together with biomaterials to promote bone regeneration will be a development direction in the future. This review will present a brief overview of the relevant mechanisms of Sr in the process of bone regeneration and the related latest studies of Sr combined with biomaterials. The aim of this paper is to highlight the potential prospects of Sr functionalized in biomaterials.

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Section: Biomaterials Compound With Srmentioning

confidence: 99%

Recent Advance of Strontium Functionalized in Biomaterials for Bone Regeneration

et al. 2023

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“…The XRD and SEM methods revealed that the consolidation of the Thus, this study demonstrates for the first time that volume-printed porous CaSiO 3 -HAp powder with a Ti6Al4V reinforcing matrix has superiority in both bone regeneration potential and mechanical development in the repair of thin-walled bone defects. In this regard, mechanically robust volume CaSiO 3 -HAp powder with a Ti6Al4V reinforcing matrix is promising for certain scenarios of bone defect repair, especially for the repair of thin-walled craniomandibular-facial bone defects [40,41].…”

Section: Discussionmentioning

confidence: 99%

CaSiO3-HAp Metal-Reinforced Biocomposite Ceramics for Bone Tissue Engineering

Папынов

Shichalin

Белов

et al. 2023

JFB

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Reconstructive and regenerative bone surgery is based on the use of high-tech biocompatible implants needed to restore the functions of the musculoskeletal system of patients. Ti6Al4V is one of the most widely used titanium alloys for a variety of applications where low density and excellent corrosion resistance are required, including biomechanical applications (implants and prostheses). Calcium silicate or wollastonite (CaSiO3) and calcium hydroxyapatite (HAp) is a bioceramic material used in biomedicine due to its bioactive properties, which can potentially be used for bone repair. In this regard, the research investigates the possibility of using spark plasma sintering technology to obtain new CaSiO3-HAp biocomposite ceramics reinforced with a Ti6Al4V titanium alloy matrix obtained by additive manufacturing. The phase and elemental compositions, structure, and morphology of the initial CaSiO3-HAp powder and its ceramic metal biocomposite were studied by X-ray fluorescence, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and Brunauer–Emmett–Teller analysis methods. The spark plasma sintering technology was shown to be efficient for the consolidation of CaSiO3-HAp powder in volume with a Ti6Al4V reinforcing matrix to obtain a ceramic metal biocomposite of an integral form. Vickers microhardness values were determined for the alloy and bioceramics (~500 and 560 HV, respectively), as well as for their interface area (~640 HV). An assessment of the critical stress intensity factor KIc (crack resistance) was performed. The research result is new and represents a prospect for the creation of high-tech implant products for regenerative bone surgery.

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“…Similarly, Su et al [69] successfully addressed the bio-inertness of Ti alloy surfaces by constructing strontium calcium phosphate (Sr-CaP) coatings on 3D-printed Ti6Al4V scaffolds. To address the bio-inertness and poor osteointegration of Ti alloys, Zhang et al [70] explored using CAD combined with 3D printing to reconstruct posterior wall fractures of acetabular fractures, assessing the biomechanical properties of porous Ti alloy scaffolds integrated with steel plates and Ti nitride bio-ceramic coatings.…”

Section: Physical Mechanical Surface Coating Technologymentioning

confidence: 99%

A Comprehensive Review of Surface Modification Techniques for Enhancing the Biocompatibility of 3D-Printed Titanium Implants

Long,

Zhu,

Jing

et al. 2023

Coatings

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The advent of three-dimensional (3D) printing technology has revolutionized the production of customized titanium (Ti) alloy implants. The success rate of implantation and the long-term functionality of these implants depend not only on design and material selection but also on their surface properties. Surface modification techniques play a pivotal role in improving the biocompatibility, osseointegration, and overall performance of 3D-printed Ti alloy implants. Hence, the primary objective of this review is to comprehensively elucidate various strategies employed for surface modification to enhance the performance of 3D-printed Ti alloy implants. This review encompasses both conventional and advanced surface modification techniques, which include physical–mechanical methods, chemical modification methods, bioconvergence modification technology, and the functional composite method. Furthermore, it explores the distinct advantages and limitations associated with each of these methods. In the future, efforts in surface modification will be geared towards achieving precise control over implant surface morphology, enhancing osteogenic capabilities, and augmenting antimicrobial functionality. This will enable the development of surfaces with multifunctional properties and personalized designs. By continuously exploring and developing innovative surface modification techniques, we anticipate that implant performance can be further elevated, paving the way for groundbreaking advancements in the field of biomedical engineering.

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Facile Fabrication of 3D-Printed Porous Ti6Al4V Scaffolds with a Sr-CaP Coating for Bone Regeneration

Cited by 15 publications

References 61 publications

Recent Advance of Strontium Functionalized in Biomaterials for Bone Regeneration

Recent Advance of Strontium Functionalized in Biomaterials for Bone Regeneration

CaSiO3-HAp Metal-Reinforced Biocomposite Ceramics for Bone Tissue Engineering

A Comprehensive Review of Surface Modification Techniques for Enhancing the Biocompatibility of 3D-Printed Titanium Implants

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