Facile Fabrication of Mussel‐Inspired Multifunctional Polymeric Membranes with Remarkable Anticoagulant, Antifouling, and Antibacterial Properties

Abstract

Herein, a facile one‐step surface modification technique of coating functional biopolymer conjugated mussel‐inspired catechol (CA) onto substrate is applied to confer polyethersulfone (PES) membranes with remarkable blood compatibility, antifouling property, and antibacterial property, respectively. CA conjugated poly(2‐acrylamido‐2‐methylpropanesulfonic acid) (PAMPS), poly(sulfobetaine methacrylate) (PSBMA), and poly(methacryloxyethyltrimethyl ammonium chloride) are synthesized via free radical polymerization in the presence of CA, and simultaneously coated onto PES membrane surface. The surface chemical compositions, surface zeta‐potential convince the successful preparation of the modified PES membranes. PAMPS‐coated membrane exhibits excellent blood compatibility, especially anticoagulation property; PSBMA‐coated membrane displays excellent antifouling property and blood compatibility; meanwhile, PDMC‐coated membrane shows robust bactericidal property. In general, this work demonstrates that the mussel‐inspired surface modification protocol provides a facile and versitile method to confer the substrate with excellent blood compatibility, antifouling property, and antibacterial property, respectively, which has great potential for multibiomedical applications, such as blood purification, hemodialysis, and organ implantation.

Mussel‐Inspired Membrane Adsorber with Thiol Ligand for Patulin Removal: Adsorption and Regeneration Behaviors

“…Many researchers found that membrane surface modification using polymers with adsorption function could improve the removal abilities of membranes for micropollutants . Inspired by the strong adhesion of mussel proteins, dopamine coating technology provided a versatile platform for construction of varied functional membranes . The combination of adsorption and separation process could impart a wider application prospect to these modified membranes …”

Surface hemocompatible modification of polysulfone membrane via covalently grafting acrylic acid and sulfonated hydroxypropyl chitosan

“…6,7 Nevertheless, PSf material is hydrophobic by nature; when it is used as blood-contacting membranes, a series of bioresponses such as apparent protein adsorption, platelet adhesion, and the activation of the clotting enzyme will occur, which directly leads to thrombogenesis. 8,9 Therefore, it is reasonable and necessary to modify pristine PSf to ameliorate its hemocompatibility.…”