Facile preparation of multifunctional uniform magnetic microspheres for T1-T2 dual modal magnetic resonance and optical imaging

Zhang, Li; Liang, Shuang; Liu, Ruiqing; Yuan, Tianmeng; Zhang, Shulai; Xu, Zushun; Xu, Haibo

doi:10.1016/j.colsurfb.2016.04.014

Cited by 19 publications

(14 citation statements)

References 47 publications

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“…These core–shell particles displayed different emission colors upon excitation by a single wavelength to distinguish cancer cells from healthy cells. Core–shell magnetic particles for magnetic resonance imaging (MRI) and optical imaging (OI) were also prepared by emulsifier‐free emulsion polymerization . The prepared particles were composed of a core containing oleic acid (OA) and sodium undecylenate (NaUA)‐modified Fe 3 O 4 nanoparticles.…”

Section: Techniques To Produce Pharmacological Nanoparticlesmentioning

confidence: 99%

“…The prepared PCL/magnetic nanoparticles were compared with commercial Gadovist, which revealed that PCL/magnetic nanoparticles were suitable for T 2 contrast enhancement while commercial Gadovist was efficient for T 1 ‐weighted images. Zhang and coworkers described the synthesis of uniform core–shell magnetic nanospheres with Fe 3 O 4 as core and polystyrene/poly glycidyl methacrylate/lanthanide complex (gadolinium and Europium) as shell, by emulsifier‐free emulsion polymerization . These core–shell composites showed dual function of MRI and OI.…”

Section: Pharmacological Nanoparticles From Emulsion Techniquesmentioning

confidence: 99%

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Emulsion Techniques for the Production of Pharmacological Nanoparticles

Jenjob

Phakkeeree

Seidi

et al. 2019

Macromolecular Bioscience

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Nanoparticles have the advantages over micron‐sized particles to typically provide higher intracellular uptake and drug bioavailability. Emulsion techniques are commonly used methods for producing nanoparticles aiming at high encapsulation efficiency, high stability, and low toxicity. Here, the recent developments of nanoparticles prepared from emulsions, the synthesis of nanoparticles, their physicochemical properties, and their biomedical applications are discussed. Selection of techniques, such as emulsion polymerization, miniemulsion polymerization, microemulsion polymerization, and emulsion‐solvent evaporation processes, strongly influences morphologies, size distributions, and particle properties. Details in the synthetic strategies governing the performance of nanoparticles in bioimaging, biosensing, and drug delivery are presented. Benefits and limitations of molecular imaging techniques are also discussed.

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Section: Techniques To Produce Pharmacological Nanoparticlesmentioning

confidence: 99%

Section: Pharmacological Nanoparticles From Emulsion Techniquesmentioning

confidence: 99%

Emulsion Techniques for the Production of Pharmacological Nanoparticles

Jenjob

Phakkeeree

Seidi

et al. 2019

Macromolecular Bioscience

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“…31–33 More recently, combining optical imaging and MRI enables both preclinical and clinical evaluations of targeted imaging probes and image-guided drug delivery and therapies. 34–39…”

Section: Introductionmentioning

confidence: 99%

Bevacizumab and near infrared probe conjugated iron oxide nanoparticles for vascular endothelial growth factor targeted MR and optical imaging

et al. 2018

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Vascular endothelial growth factor (VEGF) plays a pivotal role in the cascade of development and progression of cancers. Targeting this cancer hallmark is a logical strategy for imaging based cancer detection and monitoring the anti-angiogenesis treatment. Using Bevacizumab (Avastin®), which is a recombinant humanized monoclonal antibody directly against VEGF and an angiogenesis inhibitor, as a targeting ligand, a multimodal VEGF targeted molecular imaging probe was developed by conjugating near infrared dye (NIR830) labeled bevacizumab to magnetic iron oxide nanoparticles (IONP) for optical and magnetic resonance (MR) imaging of cancers over-expressing VEGF. The targeting effect of NIR830-bevacizumab-IONPs on VEGF over-expressing cells was investigated by receptor mediated cell uptake experiments and a blocking assay using VEGF over-expressing 4T1 breast cancer cells. Systemic administration of VEGF-targeted NIR830-bevacizumab-IONPs into mice bearing 4T1 breast tumors resulted in higher accumulation of targeting IONPs in tumors compared to non-targeted IONPs. Quantitative analysis of T2-weighted MRI at 48 h post-injection revealed that the averaged percentage of signal intensity change in tumors treated with NIR830-bevacizumab-IONPs was 52.4 ± 11.0% compared to 26.9 ± 12.4% in controls treated with non-targeted IONPs. The results demonstrated the feasibility and efficacy of NIR830-bevacizumab-IONPs as a VEGF targeting dual-modality molecular imaging probe that can be potentially used for imaging of cancers with VEGF over-expression and delivery of bevacizumab for imaging guided anti-cancer treatment.

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“…Magnetic Resonance Imaging (MRI) is a non-invasive clinical diagnostic technique with a high spatial resolution that is extensively used for anatomical imaging of soft body tissues [17,18]. In recent years, MRI has been used for tracking and monitoring cells in vivo [19].…”

Section: Introductionmentioning

confidence: 99%

“…In the case of tracking applications, cells must also be labeled with these MRI contrast agents. Small molecular paramagnetic gadolinium complexes have been extensively used for positive contrast, because these complexes act as longitudinal relaxation time (T 1 ) contrast agents [18]. In this sense, improved relaxivities rates ( r i = 1 ∕ T i ;i = 1, 2 ) have been reported for Gd complexes confined into porous media [20].…”

Section: Introductionmentioning

confidence: 99%

Glutathione-magnetite nanoparticles: synthesis and physical characterization for application as MRI contrast agent

et al. 2020

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In this work a one-pot synthesis of water soluble glutathione capped magnetite nanoparticles is reported. The magnetic characterization of the samples shows the expected superparamagnetic behavior, but a wide range of blocking temperatures is found, since the size and interparticle interactions are very sensitive to preparation conditions. These properties are correlated with the glutathione-iron ratio and oxidant dose, in order to optimize the aqueous colloidal stability and magnetic properties of the superparamagnetic iron oxide nanoparticles for Magnetic Resonance Imaging applications. The efficiency of the glutathione coated nanoparticles as contrast agent is then evaluated by means of the determination of the relaxation times T1 and T2 in 1 H Nuclear Magnetic Resonance experiments. Moreover, the influence of the thickness of the glutathione capping layer on the colloidal stability and, thus, on relaxation times has been studied. Finally, the relaxitivity of the sample that shows the best performance has been determined. Graphic abstract A novel one-pot synthesis for "in situ" functionalized hydrophilic magnetite nanoparticles at atmospheric pressure and a temperature lower than 200 °C for Magnetic Resonance Imaging applications is reported. Their properties are analyzed in terms of the synthesis process: glutathione-iron ratio and oxidant dose.

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Facile preparation of multifunctional uniform magnetic microspheres for T1-T2 dual modal magnetic resonance and optical imaging

Cited by 19 publications

References 47 publications

Emulsion Techniques for the Production of Pharmacological Nanoparticles

Emulsion Techniques for the Production of Pharmacological Nanoparticles

Bevacizumab and near infrared probe conjugated iron oxide nanoparticles for vascular endothelial growth factor targeted MR and optical imaging

Glutathione-magnetite nanoparticles: synthesis and physical characterization for application as MRI contrast agent

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