Facile synthesis of multifunctional silver nanoparticles using mangrove plant Excoecaria agallocha L. for its antibacterial, antioxidant and cytotoxic effects

Abstract

The current study describes a simple, rapid and eco-friendly method for the synthesis of silver nanoparticles (AgNPs) using Excoecaria agallocha (E. agallocha) leaf extract as stabilizer, bioreductant and capping agent. Synthesized AgNPs were characterized by UV-Visible spectroscopy (UV-Vis), X-ray diffraction (XRD), fourier transform infrared (FT-IR) spectroscopy, field emission scanning electron microscopy (FESEM) and energy dispersive X-ray spectroscopy (EDX). Generation of AgNPs was initially confirmed with the color change from yellow to dark brown which produces intense absorbance spectra at 440 nm in UV-Vis spectroscopy without any shifting of peaks. Further, XRD pattern confirms that the synthesized AgNPs was face centered cubic (fcc) crystalline in structure with an average size of 20 nm. On the other hand, FTIR spectrum reveals that the active metabolites like water soluble phenolic compounds, flavonoids, methylene groups, amides and carboxylate groups. These active biocompounds plays a vital role in the reduction of Ag ? into their nanoscale values, it also acts as a stabilizing and surface functionalization agent. FESEM micrographs of synthesized AgNPs shows spherical and hexagonal shaped well dispersed particles in the dimension ranging between 23 and 42 nm. EDAX confirms the presence of silver (Ag) as the major constituent element without any impurities; also substantiate the stability of generated AgNPs. The biomedical insights of nanoparticles (NPs) were assessed through radical scavenging and antibacterial properties. Additionally, synthesized AgNPs was also exhibits an excellent cytotoxic effect against human breast carcinoma cell lines (MCF-7). This study proves that synthesized AgNPs can be developed as a potential nano-drug formulation to combat pathogenic disease and also for the expansion of breast cancer therapy.

Biosynthesis of Silver Nanoparticles Mediated by Extracellular Pigment from Talaromyces purpurogenus and Their Biomedical Applications

“…The presence of -OH groups along with phenolic/alcoholic groups, and C–O groups with amide groups have been known to induce reduction and stabilization/capping, respectively [34,35]. Phenolic groups take part in redox reactions, which leads to the generation of quinones and donating electrons.…”

Fabrication and characterisation of silver nanoparticles using bract extract of Musa paradisiaca for its synergistic combating effect on phytopathogens, free radical scavenging activity, and catalytic efficiency

“…The average percentage of inhibition of biologically synthesised AgNPs was 62% as compared to that of MPBE (45%). Biologically fabricated AgNPs show higher radical inhibition activity than that of MPBE due to the reactivity of functional groups attached on the huge surface area of AgNPs that entrap high free radicals than that of MPBE [34, 35]. Similarly, the synthesised AgNPs and MPBE show comparable scavenging activity on ABTS + as shown in Fig.…”

Nanoparticles as Theranostic Vehicles in Experimental and Clinical Applications—Focus on Prostate and Breast Cancer

“…So far though, this technique has only been used occasionally in PCa and BC NP applications. Since EM is not considered to be an imaging technique possible to use in theranostic contexts, its value lies instead in in vitro and ex vivo analyses, as mentioned above, or during the production process of the NPs in order to be able to characterize them properly [ 401 , 402 , 403 , 404 , 405 , 406 , 407 , 408 ].…”