Facteurs de risques et diagnostic de la tuberculose

Aazri, L.; Aitbatahar, S.; Àmro, L.

doi:10.1016/j.rmra.2019.11.598

Cited by 4 publications

(5 citation statements)

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“…The most common risk factors of tuberculosis in our study were malnourishment (80%), indoor air pollution (77%) and close contact with tuberculosis patient (40%). Our results were similar in study of Aazri et al which the commonest risk factors were poorest population (70%), indoor air pollution (20%), close contact with tuberculosis patient (31%) and tabagism (31%) [16]. HIV infection is the one of the most risk factors for tuberculosis infection in sub-Saharan african countries.…”

Section: Discussionsupporting

confidence: 90%

Subxyphoid Pericardial Drainage for Tuberculous Pericardial Effusion in Antananarivo

Rajaobelison,

Randimbinirina,

Ramifehiarivo

et al. 2024

WJCS

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Introduction: Tuberculosis is the leading cause of pericardial effusion in sub-Saharan African countries. The aim of this study was to describe the diagnosis and the surgical management of tuberculous pericardial effusion in low-income country. Methods: This was a retrospective and descriptive study performed at Vascular Surgery Unit for 10 years-period (from January 2012 to December 2021), including all cases of drainage of pericardial effusion due to tuberculosis. Results: Sixty-seven cases were recorded, including 38 males (56.71%) and 29 women (43.28%). The average age was 35.47 years old. Patients lived in urban areas in 67.16% of cases. Thirteen patients (13.43%) had a previous history of pulmonary tuberculosis. The most common risk factors for tuberculosis infection were malnourishment (80.59%), indoor air pollution (77.61%) and close contact with tuberculosis patient (40.29%). The commonest symptom were dyspnea, (95.52%), chest pain (89.55%), fever (67.16%), tachycardia (95.52%) and cough (80.59%). Twenty-seven patients (39.02%) presented clinical signs of cardiac tamponade. Electrocardiogram showed sinus tachycardia (97.53%) with microvoltage (39.02%). Chest-X-ray showed cardiomegaly (100%) and pleural effusion (56.71%). Echocardiography showed moderate (43.28%) and large (56.71%) pericardial effusion. All patients underwent subxiphoid pericardial drainage. Mycobacterium tuberculosis detection via GeneXpert test of pericardial effusion were positive in 38.80% of patients. Pericardial biopsies confirmed the diagnosis of tuberculosis in 41.79%. The mortality rate was 8.95%. Conclusion: Subxiphoid peri-

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Section: Discussionsupporting

confidence: 90%

Subxyphoid Pericardial Drainage for Tuberculous Pericardial Effusion in Antananarivo

Rajaobelison,

Randimbinirina,

Ramifehiarivo

et al. 2024

WJCS

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“…Our work aimed to assess the prevalence of SARS-CoV-2 RNA carriage in TB patients and to determine the factors associated with this carriage in a tuberculosis-endemic area represented by a major tuberculosis referral center in Cameroon. One hundred and eighty-five pulmonary TB patients were included with a male predominance of 57.8% (107/185) and a sex ratio of 1.36; this gender disparity in the prevalence of tuberculosis is also found in most countries with a high prevalence of tuberculosis [ 15 ] and there is no consensus on the reasons that can explain it [ 12 ]. However, the high prevalence of certain recognized risk factors for tuberculosis in male subjects could explain this [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…According to some authors, risk factors such as age and comorbidities are determinants of mortality in people co-infected with COVID-19/TB and, co-infection could be associated with the worsening of the disease and an increase in fatality rate [ 7 - 10 ]. Other research works suggest common protective factors such as the Bacille Calmette-Guérin (BCG) vaccine, and the level of interferon-gamma (IFN- γ) [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of tuberculosis/COVID-19 co-infection and factors associated with SARS-CoV-2 infection in pulmonary tuberculosis patients at a respiratory diseases center: a cross-sectional study

Mangamba¹,

Medi²,

Tochie³

et al. 2023

Pan Afr Med J

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Introduction currently, tuberculosis (TB) is the second cause of infectious disease-related deaths before COVID-19. These two infections have several similarities but little data is available on TB/COVID-19 co-infection, hence, we sought to investigate the prevalence of this co-infection and the factors associated with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in tuberculosis patients in a tuberculosis-endemic area. Methods we conducted a prospective cross-sectional study from January to June 2022 at Respiratory Diseases Center in Douala, Cameroon by enrolling all consenting pulmonary tuberculosis patients. The presence of SARS-CoV-2 ribonucleic acid (RNA) and gamma-interferon levels were laboratory analyzed using the Reverse Transcriptase-Polymerase Chain Reaction and the enzyme-linked immunosorbent assay (ELISA) technique, respectively. The factors associated with COVID-19 carriage in pulmonary tuberculosis patients were analyzed by logistic regressions. Results overall, we enrolled 185 patients; 57.8% were males (sex ratio of 1.36) and their mean age was 43.70 ± 17.89 years. The prevalence of SARS-CoV-2 RNA in pulmonary TB patients was 24.3%. Asthma and sore throat were the factors favoring carriage (OR=3.74; 95% CI=1.271-11.017; p=0.017 and OR=4.05; 95%CI=1.204-13.600; p=0.024) and cough was a protective factor (OR=0.15; 95% CI = 0.034-0.690; p=0.015). Conclusion the prevalence of SARS-CoV-2 carriage in tuberculosis patients is high and greater than the national prevalence. Asthma and sore throat would be associated factors.

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“…This high frequency is because of factors specific to chronic dialysis patients, notably cellular immune deficiency, the chronic inflammatory state induced and maintained by the bio-incompatibility of the dialysis material, undernutrition, and high ferritin levels [ 2 , 11 , 13 ], which are associated with other factors found in the general population (age, low socioeconomic level, promiscuity, lack of vaccination, recent tuberculosis contagion, toxic habits, immunosuppressive treatment, and comorbidities) [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Tuberculosis in Dialysis Patients in the Central Region of Morocco: What Is the Health-Care Delay?

Bardai¹,

Kabbali²,

Baba³

et al. 2022

Cureus

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Introduction: Due to the predominantly cellular immunosuppression, infections are frequent in chronic dialysis patients, in particular tuberculosis (TB). The main objective of our study is to evaluate tuberculosis healthcare delay in dialysis patients and to raise the diagnostic challenge in these patients. Material and methods: The study is retrospective and multicenter including tuberculosis cases of chronic dialysis patients either in hemodialysis (HD) or peritoneal dialysis (PD) in the central region of Morocco during a 10-year period between 2012 and 2021. Results: We included 94 patients, five of whom were in PD, with a mean age of 50.79 ± 16.72 years, and a sex ratio of 0.67. The time between the initiation of dialysis and the onset of the clinical and biological presentation was 50.3 ± 67.12 months. The most frequent initial manifestations were an alteration of the general state (85.1%), a biological inflammatory syndrome (83%) or a prolonged fever (70.1%). Among our 94 patients, the diagnosis was confirmed with bacteriological evidence only in 18 cases (19.1%), by identification of Koch's Bacillus (BK) in 13 cases, by molecular biology test (GeneXpert; Cepheid, Inc., Sunnyvale, CA, USA) in five cases. The diagnosis of tuberculosis was presumptive in most cases (79 cases), i.e. 80.9%. Twenty-one patients underwent the interferon gamma release essay test (QuantiFERON; Qiagen, Hilden, Germany) which was positive in 14 patients. Thirty-four (36.1%) cases had a histological diagnosis. The remaining patients were offered a trial treatment. Tuberculosis localization was mostly extra-pulmonary (75.5%): lymph node (23.4%), pleural (13.8%), peritoneal (13.8%), whereas it was pulmonary in 23 cases (24.5%). Most of our patients had a clear delay in management from symptom onset to initiation of anti-TB treatment 78.9% (time >21days) vs 21.1% (time ≤21days). The median time to management delay was 46.5 interquartile range (IQR) (28.5-90), the mean delay was 78.4 ± 87.9 (6-360). All patients were treated according to the RHZE/RH protocol (R: rifampicin, H: isoniazid Z: pyrazinamide and E: ethambutol), with a duration between six and 18 months. Side effects associated with anti-tuberculosis treatment were observed in half of the patients (51.1%). The evolution was favorable with remission and improvement of the general condition in 90% of cases. Two cases of resistance were noted in our series. The overall mortality was 7.7%. Conclusion: We have confirmed a delay in the diagnosis and treatment of tuberculosis in chronic dialysis patients. This can be explained by the often atypical or incomplete clinical and paraclinical presentation and the extra-pulmonary localizations, making diagnosis difficult in this population whose prognosis remains poor. It is therefore necessary to establish a diagnostic approach that is adapted to the specificities of these high-risk patients within the framework of a national tuberculosis control program.

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Facteurs de risques et diagnostic de la tuberculose

Cited by 4 publications

References 0 publications

Subxyphoid Pericardial Drainage for Tuberculous Pericardial Effusion in Antananarivo

Subxyphoid Pericardial Drainage for Tuberculous Pericardial Effusion in Antananarivo

Prevalence of tuberculosis/COVID-19 co-infection and factors associated with SARS-CoV-2 infection in pulmonary tuberculosis patients at a respiratory diseases center: a cross-sectional study

Tuberculosis in Dialysis Patients in the Central Region of Morocco: What Is the Health-Care Delay?

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