Facteurs prédictifs de la survenue du stress post-traumatique chez des individus ayant vécu deux évènements de vie majeurs (tremblement de terre et terrorisme en Algérie) : réponse corticotrope et prolactinique à une faible dose de dexaméthasone (0,5mg)

Disturbances in the activity of the corticotropic axis and immune system have been widely reported to be linked to the development of depression. The aim of this study was to explore the effects of ketoconazole, an imidazole derivative that inhibits gonadal and adrenal steroidogenesis, on changes in the total leukocyte count and the percentages of leukocyte subpopulations during the Porsolt forced swimming test (commonly used to measure the efficiency of antidepressants) in rats. Catheters were implanted in the carotid under general anesthesia, and blood samples (0.2 mL) were taken at 15 min intervals. Animals were allowed to move freely throughout the experiments. The levels of anxiety and locomotor activity were measured using the elevated plus-maze and open-field tests. Forced swimming induced changes in both the testosteronemia and the immune system, and these changes were inhibited by treatment with ketoconazole. An improvement (anxiolytic and antidepressant effects) in the behavioral response (elevated plus maze, forced swim) was also observed. These results suggest that the relationship between behavioral and physiological responses is multifactorial and that corticosterone plays a major role in the pathogenesis of psychiatric disorders.

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Le kétoconazole antagonise les effets immuno-gonadotropes au test de la nage forcée chez le rat mâle Wistar

Frih

Djenidi

Rachedi

et al. 2010

Can. J. Physiol. Pharmacol.

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Drug-induced hypo- and hyperprolactinemia: mechanisms, clinical and therapeutic consequences

Voicu

Medvedovici

Ranetti

et al. 2013

Expert Opinion on Drug Metabolism & Toxicology

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Accurate monitoring and evaluation of the hyperprolactinemia induced by xenobiotics is strongly recommended. The typical antipsychotics and some of the atypical agents (amisulpride, risperidone, paliperidone), as well as some antidepressants, antihypertensives and prokinetics, are the most important groups inducing hyperprolactinemia. The hyperprolactinemic effects are correlated with their affinity for dopamine D2 receptors, their blood-brain barrier penetration and, implicitly, the requested dose for adequate occupancy of cerebral D2 receptors. Consequently, integration of available pharmacokinetic and pharmacodynamic data supports the idea of therapeutic switch to non-hyperprolactinemic agents (especially aripiprazole) or their association, for an optimal management of antipsychotic-induced hyperprolactinemia. Possible alternative strategies for counteracting the xenobiotics-induced hyperprolactinemia are also mentioned.

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Facteurs prédictifs de la survenue du stress post-traumatique chez des individus ayant vécu deux évènements de vie majeurs (tremblement de terre et terrorisme en Algérie) : réponse corticotrope et prolactinique à une faible dose de dexaméthasone (0,5mg)

Cited by 2 publications

References 31 publications

Le kétoconazole antagonise les effets immuno-gonadotropes au test de la nage forcée chez le rat mâle Wistar

Le kétoconazole antagonise les effets immuno-gonadotropes au test de la nage forcée chez le rat mâle Wistar

Drug-induced hypo- and hyperprolactinemia: mechanisms, clinical and therapeutic consequences

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