In order to explore the law of major and extra serious traffic accidents on expressways in China, a total of 802 cases of major and extra serious traffic accidents on expressways in the past 10 years were collected, and statistical analysis was conducted from the aspects of time distribution, spatial distribution, accident form, and accident cause. The results show that in the past 10 years, the incidence and casualties of major and extra-serious traffic accidents on expressways have shown a fluctuating downward trend. In January, May, August, and November every year, between 6: 00 and 8: 00 every day is the highest incidence of accidents. The Guangxi Zhuang Autonomous Region, Heilongjiang Province, Fujian Province, and Anhui Province have more accidents. Vehicle collisions have the highest number of deaths, and rollover injuries have the highest rate. Human factors accounted for 72.1% of the causes of accidents, among which improper measures and speeding accounted for the largest proportion. Finally, according to the results of data statistical analysis, the corresponding control measures should be put forward in order to provide reference and technical support for the current highway traffic safety situation and safety management policy.