Factor V Leiden mutation and type 1 diabetes mellitus

Abstract

Diabetes mellitus is considered to cause a tendency for arterial thrombosis. Recent studies addressed the association between venous and arterial disease. Resistance to activated protein C is one of the most common causes of venous thrombosis and linked to a single point mutation in the factor V gene, designated as factor V Leiden mutation. There is little information regarding the status of factor V Leiden mutation in type 1 diabetes. The aim of this study is to evaluate association among activated protein C sensitivity ratio, factor V Leiden mutation, and type 1 diabetes taking into account metabolic control, lipids and diabetic complications. The study population consisted of 47 healthy subjects (27.9 +/- 1.2 years) and 48 type 1 diabetic patients (27.9 +/- 1.1 years). Activated protein C sensitivity ratio was measured by activated partial thromboplastin time based assay. The presence of factor V Leiden mutation was determined by amplifying the fragments encompassing gene mutation by PCR. Mean normalized activated protein C sensitivity ratio values and prevalence of heterozygous factor V Leiden mutation were not significantly different between groups (1.08 +/- 0.03 and 6.3% in healthy subjects; 1.01 +/- 0.03 and 6.4% in type 1 diabetic patients, respectively). The activated protein C sensitivity ratio and factor V Leiden mutation were not found to be linked with metabolic control parameters, lipids and diabetic complications in type 1 diabetic patients. There was no association among factor V Leiden mutation, activated protein C sensitivity ratio and type 1 diabetes, metabolic control parameters as well as complications of diabetes. Although the propensity to thrombosis is increased in individuals with type 1 diabetes, activated protein C sensitivity ratio and factor V Leiden mutation do not appear to be significant determinants.

Factor V G1691A, prothrombin G20210A and methylenetetrahydrofolate reductase polymorphism C677T are not associated with coronary artery disease and type 2 diabetes mellitus in western Iran

“…In one study, a relation between factor V Leiden and diabetes was indicated whereas other studies failed to show association between factor V Leiden and prothrombin G20210A with diabetes [11][12][13]34]. In our present study, we did not detect an association between factor V Leiden, prothrombin G20210A variant and MTHFR C677T with diabetes.…”

Is there a relationship between factor V Leiden and type 2 diabetes?

“…However, it is already not known why such patients with diabetes develop more vascular complications both as atherothrombosis (of any district) as VTE and other patients with diabetes do not develop vascular complication. In previous years several research suspected a relationship between diabetes and FVL gene variants both for type 1 or type 2 diabetes but not univocal data were found [ 14 - 16 ]. Krekora et al in fact suspected also a possible genetic co-segregation for both inherited disorders (i.e.…”

“…A possibile relationship between the presence of FVL gene variant and type 1 or type 2 diabetes has been hypothysed by several reports in the Literature with non-univocal findings [ 14 - 16 ].…”