Factor XIII and Fracture Healing

Benfer, J; Struck, H

doi:10.1159/000127940

Cited by 23 publications

(6 citation statements)

References 3 publications

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“…Our data are in close agreement with the results obtained by Benfer & Struck (1977) on the influence of Factor Thirteen on fracture healing in rats; whereas we investigated the early phase of fracture healing, their studies showed that the difference in tensile strengths between treated and untreated fractures decreased with time.…”

Section: Discussionsupporting

confidence: 92%

“…These results provide a possible explanation for the findings of Hellerer et al (1980) who were unable to demonstrate any differences in mineral content between treated and untreated animals. Benfer & Struck (1977) found significant differences with tensile strength testing. The parameter most closely correlated with bone strength was found to be the number of osteons crossing the osteotomy site, a value which clearly reflects the structure of the healing bone.…”

Section: Discussionmentioning

confidence: 90%

“…The efficacy of this factor is due to its ability to enhance fibrin cross-linking and to stimulate fibroblast proliferation (Beck et al 1961). Benfer & Struck (1977) found that Factor Thirteen produced higher tensile strengths and histological evidence of accelerated healing of rat fractures, whereas Hellerer et al (1980) in a similar animal model found no effects on callus formation and mineral salt density.…”

mentioning

confidence: 99%

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Bone healing stimulated by plasma Factor XIII: Osteotomy experiments in sheep

Burri

Gerngroß

Mutschler

1985

Acta Orthopaedica Scandinavica

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Sheep had their right metatarsals osteotomized midshaft and stabilized by plate and screws. One group was injected with 1250 units of Factor Thirteen for 9 days postoperatively, and a control group received placebo injections. After 8 weeks, the bones were evaluated biomechanically, histomorphologically and by densitometry. The bones of the treated group had a significantly higher tensile strength than the bones of the control animals. The correlation of biomechanical and morphological results demonstrated that the tensile strength increased with an increasing number of osteons crossing the osteotomy gap. The hydroxyapatite content of the bone healing zone was 7.3 per cent higher for the treated bones than for the control bones.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 90%

mentioning

confidence: 99%

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Bone healing stimulated by plasma Factor XIII: Osteotomy experiments in sheep

Burri

Gerngroß

Mutschler

1985

Acta Orthopaedica Scandinavica

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“…Only a few studies have focused on the actual bone fracture‐healing capability of pFXIII in animal models, but they indicate a positive effect on early bone healing. Thus, in sheep and rat fracture models, an increased level of pFXIII correlates with increases in the tensile strength and the number of newly formed osteons in the bone . These findings seem to correlate with the proposed roles of pFXIII in bone healing, namely cross‐linking of the ECM and stimulation of chondrocyte and osteoblast proliferation and differentiation.…”

Section: Potential Clinical Use Of Fxiiimentioning

confidence: 65%

Tissue-regenerating functions of coagulation factor XIII

Soendergaard

Kvist

Seidelin

et al. 2013

Journal of Thrombosis and Haemostasis

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To cite this article: Soendergaard C, Kvist PH, Seidelin JB, Nielsen OH. Tissue-regenerating functions of coagulation factor XIII. J Thromb Haemost 2013; 11: 806-16. Summary. The protransglutaminase factor XIII (FXIII) has recently attracted attention within the field of tissue regeneration, as it has been found that FXIII significantly influences wound healing by exerting a multitude of functions. It supports hemostasis by enhancing platelet adhesion to damaged endothelium, and by its cross-linking activity it stabilizes the formed fibrin clot. Furthermore, FXIII limits bacterial dissemination from the wound and incorporates macromolecules of importance for cellular infiltration, supporting cell migration and survival. FXIIImediated complex formation of the vascular endothelial growth factor receptor 2 and a V b 3 integrin is important for angiogenesis, supporting the formation of granulation tissue. Chronic inflammatory conditions involving bleeding and activation of the coagulation cascade have been shown to lead to reduced FXIII levels in plasma. Of particular importance for this review is the fact that patients suffering from inflammatory bowel disease (IBD) have reduced FXIII antigen levels and activity. Furthermore, these patients show impaired mucosal healing, which supports the inflammatory state of the disease. This review summarizes the role of FXIII in the healing of wounds, and briefly summarizes the previous use of FXIII in clinical settings. Moreover, it addresses the potential role for FXIII as a therapeutic agent in the healing of persistent wounds during chronic conditions, with an emphasis on IBD.

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“…Polymeren, Verminderung der fibrinolytischen Aktivität durch Einlagerung von a 2 -Antiplasmin in das gebildete Fibrin) zunehmend an Bedeutung bei der Behandlung von Wundheilungsstörungen (1,2,3,4,5), Bindegewebserkrankungen wie z. B. Sklerodermien (6, 7, S), Vaskulitiden wie Schönlein-Henoch-Purpura (9,10,11,12), entzündlichen Darmerkrankungen, wie Morbus Crohn und Colitis ulcerosa (13,14,15,16), Leukämien (17,18), Subarachnoidalblutungen (19,20) sowie bei der Förderung der Knochenheilung (2,21,22,23,24,25). Dies führt zu einer ständig steigenden Zahl der Anforderungen von Faktor Xlll-Bestimmungen.…”

Section: Introductionunclassified

Klinische Prüfung eines neuen photometrischen Tests zur Bestimmung der Faktor XIII-Aktivität im Plasma

Solleder¹,

Domuth²,

Pfeiffer³

et al. 1992

LaboratoriumsMedizin

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Zusammenfassung: Ein neu entwickelter photometrischer Test (Berichrom F XIII) zur Bestimmung der Faktor-XI 11-Aktivität im Plasma wurde sowohl am Cobas Fara als auch in der manuellen Version am Spektralphotometer geprüft. Bei diesem Test wird die durch NADH-Verbrauch verursachte Absorptionsabnahme bei 340 nm gemessen. Das NADH wird während der durch Glutamatdehydrogenase katalysierten Inkorporation des mittels einer F Xllla-Reaktion freigesetzten NH 3 in -Ketoglutarat verbraucht. Die Absorptionsabnahme ist porportional zur F Xlll-Aktivität in der Probe. Der Test zeichnet sich durch eine hohe Präzision, eine gute Korrelation mit dem Clot-Lyse-Test, durch seine Unempfindlichkeit gegen Störeinflüsse, seine Schnelligkeit und einfache Durchführbarkeit aus. Er wird zu einer enormen Erleichterung der F Xlll-Bestimmungen in den klinischen Labors führen. Schlüsselwörter: Faktor Xlll-Transamidase -Clot-Lyse-Test -NADH-abhängige Bestimmung -Zentrifugalanalyzer Summary: A new developed photometric assay (Berichrom F XIII) for the detection of factor XIII activity in plasma was tested. In this assay the decrease in absorbance caused by NADH consumption due to incorporation of NH 3 is detected at 340 nm. This NH 3 is released in a F Xllla catalyzed reaction into -ketoglutarate with the aid of glutamate dehydrogenase. The maximal rate of this decrease in absorbance at 340 nm is proportional to the activity of F Xllla in the sample.. This new assay can easily be performed on clinical analyzers or usual photometers. The test reveals a high precision, a good correlation to the clot lysis test and is insensitive to interferences. Due to its rapid and easy performance this assay will contribute to simplify determinations of F XIII in clinical laboratories.

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Factor XIII and Fracture Healing

Cited by 23 publications

References 3 publications

Bone healing stimulated by plasma Factor XIII: Osteotomy experiments in sheep

Bone healing stimulated by plasma Factor XIII: Osteotomy experiments in sheep

Tissue-regenerating functions of coagulation factor XIII

Klinische Prüfung eines neuen photometrischen Tests zur Bestimmung der Faktor XIII-Aktivität im Plasma

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