Factors affecting bacterial biofilm expression in chronic rhinosinusitis and the influences on prognosis

You, Huihua; Zhuge, Pan; Li, Dong; Shao, Lingyun; Shi, Honglian; Du, Huanle

doi:10.1016/j.amjoto.2010.11.017

Cited by 26 publications

(21 citation statements)

References 29 publications

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“…Some authors reported that the Lund-Kennedy scores 6 and 12 months after surgery were significantly higher in biofilm-positive patients than in biofilm-negative patients. They also reported that bacterial biofilms affect prognosis [11,28]. Some authors reported poorer postoperative CT scores, postoperative symptoms, mucosal outcome, extra postoperative visits, and multiple antibiotic therapy in biofilmpositive patients [10,13].…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics of Biofilms in Patients with Chronic Rhinosinusitis: A Prospective Case–Control Study

Jung

Eog

Kang

et al. 2014

Indian J Otolaryngol Head Neck Surg

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Recent studies have indicated that biofilms are involved in the pathogenesis of recurrent and recalcitrant chronic rhinosinusitis (CRS). The present study was performed to evaluate the presence of biofilms and to evaluate the relationships between the presence of biofilms and clinical features of CRS. A total of 33 patients were included in this study. Maxillary sinus mucosa from 26 CRS patients and the ethmoid mucosa from 7 patients undergoing septoplasty were collected. Biofilms were evaluated by scanning electron microscopy. Preoperative symptom scores, preoperative and intraoperative nasoendoscopic findings, and postoperative healing period were compared between the groups. Biofilms were detected in 14 (42.4 %) of the 33 patients. Biofilms were present in 13 (50 %) of the 26 patients in the CRS group, but in only one (14.3 %) of the seven patients in the control group. There were no significant differences in preoperative symptom scores or preoperative nasal Lund-Kennedy endoscopic scores between the groups. However, the average LundMackay and intraoperative sinus Lund-Kennedy endoscopic scores were significantly higher in biofilm-positive than biofilm-negative patients (P \ 0.05). In the follow-up period, the healing time was significantly longer in biofilmpositive than biofilm-negative patients (P \ 0.05). This study suggested that the presence of bacterial biofilms may contribute to the pathogenesis of CRS and the clinical characteristics of CRS patients after endoscopic sinus surgery.

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Section: Discussionmentioning

confidence: 99%

Clinical Characteristics of Biofilms in Patients with Chronic Rhinosinusitis: A Prospective Case–Control Study

Jung

Eog

Kang

et al. 2014

Indian J Otolaryngol Head Neck Surg

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“…A study from China found bacterial biofi lm formation (judged by scanning electron microscopy of sinus mucosal specimens) occurred 64 of 90 CRS patients (71.1 %) (You et al 2011 ). These were compared to a control group of 20 patients without CRS who also underwent sinus mucosal biopsy.…”

Section: Clinical Studies Of Patients With Bacterial Biofi Lmsmentioning

confidence: 98%

Biofilm Formation by Clinical Isolates and Its Relevance to Clinical Infections

Akers

Cardile

Wenke

et al. 2014

Advances in Experimental Medicine and Biology

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Reports of biofilms have increased exponentially in the scientific literature over the past two decades, yet the vast majority of these are basic science investigations with limited clinical relevance. Biofilm studies involving clinical isolates are most often surveys of isolate collections, but suffer from lack of standardization in methodologies for producing and assessing biofilms. In contrast, more informative clinical studies correlating biofilm formation to patient data have infrequently been reported. In this chapter, biofilm surveys of clinical isolates of aerobic and anaerobic bacteria, mycobacteria, and Candida are reviewed, as well as those pertaining to the unique situation of cystic fibrosis. In addition, the influence of host components on in vitro biofilm formation, as well as published studies documenting the clinical impact of biofilms in human infections, are presented.

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“…The human nasopharynx is the main reservoir for S. pneumoniae and pneumococcal colonization always precedes infection [168]. Striking differences between biofilm Once established, biofilms may induce changes in the mucociliary blanket like destruction of the epithelial layer and absence of cilia, and a local inflammatory response [158][159][160][161]. This suggests epithelial damage being a part of the pathogenesis of biofilm-associated CRS.…”

Section: Chronic Rhinosinusitis (Crs)mentioning

confidence: 99%

Bacterial Biofilm and its Role in the Pathogenesis of Disease

et al. 2020

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Recognition of the fact that bacterial biofilm may play a role in the pathogenesis of disease has led to an increased focus on identifying diseases that may be biofilm-related. Biofilm infections are typically chronic in nature, as biofilm-residing bacteria can be resilient to both the immune system, antibiotics, and other treatments. This is a comprehensive review describing biofilm diseases in the auditory, the cardiovascular, the digestive, the integumentary, the reproductive, the respiratory, and the urinary system. In most cases reviewed, the biofilms were identified through various imaging technics, in addition to other study approaches. The current knowledge on how biofilm may contribute to the pathogenesis of disease indicates a number of different mechanisms. This spans from biofilm being a mere reservoir of pathogenic bacteria, to playing a more active role, e.g., by contributing to inflammation. Observations also indicate that biofilm does not exclusively occur extracellularly, but may also be formed inside living cells. Furthermore, the presence of biofilm may contribute to development of cancer. In conclusion, this review shows that biofilm is part of many, probably most chronic infections. This is important knowledge for development of effective treatment strategies for such infections.

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Factors affecting bacterial biofilm expression in chronic rhinosinusitis and the influences on prognosis

Cited by 26 publications

References 29 publications

Clinical Characteristics of Biofilms in Patients with Chronic Rhinosinusitis: A Prospective Case–Control Study

Clinical Characteristics of Biofilms in Patients with Chronic Rhinosinusitis: A Prospective Case–Control Study

Biofilm Formation by Clinical Isolates and Its Relevance to Clinical Infections

Bacterial Biofilm and its Role in the Pathogenesis of Disease

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