Factors affecting mandibular complications in low dose rate brachytherapy for oral tongue carcinoma with special reference to spacer

Miura, Masahiko; Takeda, Masamune; Sasaki, Takuma; Inoue, Takahiro; Nakayama, Takeo; Fukuda, Haruki; Hoshi, Akihiko; Hoshina, Masao; Shibuya, Hitoshi

doi:10.1016/s0360-3016(98)00118-7

Cited by 51 publications

(31 citation statements)

References 21 publications

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“…Owing to the adverse effects of treatment with external irradiation, patients with head and neck cancer experience bouts of serious illness, debility and numerous symptoms including pain, dysphagia, weight loss and xerostomia [9,10]. However, most early and late complications of brachytherapy for tongue cancer are limited to the area treated, and patients recover in several months [4,5,8]. There is a report that age is a factor influencing the outcome of tongue cancer treatment [11].…”

Section: Discussionmentioning

confidence: 99%

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Brachytherapy for tongue cancer in the very elderly is an alternative to external beam radiation

Khalilur

Hayashi²,

Shibuya³

2011

BJR

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Background: The result of curative treatment for very elderly patients with tongue carcinoma has not been reported to date. We retrospectively reviewed the results of brachytherapy in 125 the patients aged over 75 years. Methods: The results of brachytherapy in 125 patients, 75 years old or older, with Stage I or II squamous cell carcinoma of the oral tongue were reviewed. The 125 cases consisted of 31 Stage I and 94 Stage II cases; 67 patients were under 80 years old and 58 were over 80 years old. All patients were treated using low-dose-rate brachytherapy (

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Section: Discussionmentioning

confidence: 99%

“…There were no changes in the dose during the entire period of treatment, and the standard brachytherapy dose was 70 Gy in 7 days. Spacers were routinely prepared in the brachytherapy after 1987 to prevent osteoradionecrosis of the mandible [8].…”

Section: Methodsmentioning

confidence: 99%

Brachytherapy for tongue cancer in the very elderly is an alternative to external beam radiation

Khalilur

Hayashi²,

Shibuya³

2011

BJR

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“…The treatment policy and method of performing LDR-BT for oral cancer used at our institution have been described previously [3][4][5][6][7][8][9]. The usual dose prescribed for the treatment of tongue cancer with linear sources of caesium-137 or iridium-192 was 70 Gy over a period of 5-7 days, and the dose distribution was always calculated using computer dosimetry after implantation.…”

Section: Treatmentmentioning

confidence: 99%

“…Low-dose-rate brachytherapy (LDR-BT) has played a particularly important role in the treatment of early oral cancer because it delivers a high radiation dose to a limited volume while sparing the surrounding tissues and yields results similar to those of surgery. Moreover, the patients' physical and mental stress levels are considered to be lower than those for surgery or external-beam radiotherapy (EBRT) because the LDR-BT sources are implanted under local anaesthesia and LDR-BT has a low incidence of complications [3][4][5][6][7][8][9][10][11][12]. Therefore, LDR-BT is performed at our institution even for the treatment of patients judged to be inoperable by surgeons or anaesthetists because of advanced age, severe comorbidity or any other reason.…”

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confidence: 99%

Disease control using low-dose-rate brachytherapy is unaffected by comorbid severity in oral cancer patients

Yoshimura

Shibuya²,

Hayashi³

et al. 2011

BJR

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Objective: The aim of this study was to evaluate the outcome and complications of low-dose-rate brachytherapy (LDR-BT) for oral cancer according to comorbidity. Methods: The records of a total of 180 patients who received LDR-BT for T1-2N0M0 oral cancers between January 2005 and December 2007 were analysed. The comorbidities of the patients were retrospectively graded according to the Adult Comorbidity Evaluation-27, and the relationships between the comorbidity grades and survival, disease control and the incidence of complications were analysed. Results: The 2 year overall survival rates of patients with no comorbidity, Grade 1, Grade 2 and Grade 3 comorbidity were 87%, 85%, 76% and 65%, respectively, and the reduction in the survival rate according to comorbid severity was significant in a univariate analysis (p50.032) but not in a multivariate analysis including other clinical factors. Cause-specific survival, locoregional control and local control were not related to the comorbidity grade, or any other clinical factors. Grade 2 or 3 complications developed in 27% of the patients. The incidence of complications was unrelated to the comorbidity grade. Conclusion: The disease control of oral cancer and the incidence of complications after LDR-BT were not related to comorbid severity. LDR-BT is a useful and safe treatment for patients regardless of the presence of severe comorbidity.

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“…11 In another study, spacers were observed to protect against mandibular complications in low-dose brachytherapy for oral tongue carcinoma. 12 An epidemiologic study was also conducted on the quality of life (QOL) in patients with severe myopia 13 and on the relationship between labor stress and depression/suicide. 14,15 The latter report, a collaboration with psychiatrists on a case series of suicide attributed to overwork 15 was the first detailed descriptive study of its type regarding this phenomenon, which is unique to Japan.…”

Section: Evidence-based Health Care and Health Informaticsmentioning

confidence: 99%

Evidence-based Healthcare and Health Informatics: Derivations and Extension of Epidemiology

Nakayama¹

2006

Journal of Epidemiology

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Epidemiology provides extremely valid information and evidence regarding human health. Epidemiologic findings with regard to major illnesses must be amassed, enhanced, and expanded further into related areas as a foundation for evidence-based medicine that is based on clinical practice, as well as for evidence-based healthcare that includes public health-related issues. Epidemiology should be recognized not only by epidemiologists but also by a variety of people, including specialists in other areas for healthcare and medicine, people in law and media, policy makers, and the general public. A system is needed that can create information for facilitating appropriate decision-making with issues related to clinical medicine and public health. The principles and methodology of epidemiology are used as a base for developing a field of health informatics. The objective of health informatics is to establish a system for facilitating the flow and circulation of health and medical information. Health informatics has potential applications for the creation, communication, and use of information, and the discipline is being expanded as a practical applied science in search of solutions. This report represents an effort to expand the scope of health informatics and extend the applications of epidemiology by working with individuals in other disciplines and the public.

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Factors affecting mandibular complications in low dose rate brachytherapy for oral tongue carcinoma with special reference to spacer

Cited by 51 publications

References 21 publications

Brachytherapy for tongue cancer in the very elderly is an alternative to external beam radiation

Brachytherapy for tongue cancer in the very elderly is an alternative to external beam radiation

Disease control using low-dose-rate brachytherapy is unaffected by comorbid severity in oral cancer patients

Evidence-based Healthcare and Health Informatics: Derivations and Extension of Epidemiology

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