Factors associated with mortality in patients hospitalized with COVID-19: A prospective cohort in a Peruvian national referral hospital

Vences, Miguel A.; Pareja-Ramos, Juan J.; Otero, Paula; Veramendi-Espinoza, Liz; Vega-Villafana, Melissa; Mogollón-Lavi, Julissa; Morales-Romero, Eduardo; Olivera-Vera, Josseline; Meza, Carol; Salas-Lazo, Lucía J; Triveño, Andy; Marín-Dávalos, Renzo; Rodriguez, Ricardo Carpio; Zafra-Tanaka, Jessica Hanae

doi:10.5867/medwave.2021.06.8231

Cited by 16 publications

(16 citation statements)

References 24 publications

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“…(5) A preliminary report of a study carried out in a reference hospital in Peru showed an association between the presence of stroke and mortality in patients admitted for COVID-19 (RR = 1.49). They concluded that the presence of stroke is a poor prognostic factor in patients with COVID-19 (26). Previous studies conducted in Peru before the pandemic, reported a rate of 42-68% of patients with independence (mRS0-1) after thrombolysis.…”

Section: Discussionmentioning

confidence: 94%

Cerebrovascular disease and mortality in hospitalized patients with COVID-19 in a Latin American country, Peru.

Gallo-Guerrero¹,

Vences²,

Zafra-Tanaka³

et al. 2022

Rev Neuropsiquiatr

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Objective: This study aimed at: 1) Assessment of the frequency of stroke and related mortality rate in patients hospitalized for COVID-19 in two major hospital referral centers in Peru; 2) Exploration of factors associated to mortality and dependency in these patients; 3) Comparisons of frequency of admissions of stroke patients and reperfusion treatments in similar periods of time prior to (2019) and during the pandemia occurrence. Material and Methods: A retrospective cohort study was conducted in two of the largest referral hospital centers for COVID-19 in Peru. The study included patient victims of stroke and COVID-19, hospitalized between April and August 2020. Demographic, clinical and laboratory data, radiological findings, and severity levels measured by the NIHSS scale were collected. Poisson regression models to evaluate associated factors to mortality and dependency were applied. Results: A 31% reduction of admissions for stroke, and of 81% of intravenous reperfusion treatment, respectively, were found in 2020 when compared with 2019. 1.37% of the patients with COVID-19 experienced a stroke, with an overall mortality rate of 40.6%, and a dependency rate of 68.3% at discharge time (Rankin > 2). An age increase of 10 years was found in mortality, associated with a 29% increase in mortality risk. As well, having hypertension, chronic kidney disease, inflammatory markers (D dimer and ferritin) and the severity of the stroke were associated with mortality. Finally, the severity of stroke, lymphopenia, and inflammatory markers (D dimer and fibrinogen) were associated with greater risk of dependency. Conclusions: The care system of stroke patients was affected by the COVID-19 pandemic in two of Perú’s major public hospitals. There was a decrease in admissions and reperfusion treatments of stroke cases, and 1.37% of patients with COVID-19 presented a stroke. Age, hypertension, chronic kidney disease, inflammatory markers and severity of stroke were associated with mortality in these patients.

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Section: Discussionmentioning

confidence: 94%

Cerebrovascular disease and mortality in hospitalized patients with COVID-19 in a Latin American country, Peru.

Gallo-Guerrero¹,

Vences²,

Zafra-Tanaka³

et al. 2022

Rev Neuropsiquiatr

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“…hallaron que la mortalidad se vio asociada a la edad (pacientes mayores a 60 años), a los marcadores inflamatorios y al compromiso pulmonar. 35 Sin embargo, en nuestro análisis no encontramos factores riesgo asociados a mortalidad, pensamos que posiblemente esto sea causa del rango etario de los pacientes ingresados previamente discutido, sin dejar de lado al escaso tamaño de la cohorte analizada.…”

Section: Discussionunclassified

Impacto del decúbito prono en pacientes con COVID-19 grave en un hospital de agudos de la Ciudad Autónoma de Buenos Aires.

et al. 2023

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Resumen Introducción: El decúbito prono (DP) fue la estrategia más utilizada en paciente con COVID-19 e hipoxemia refractaria. Nuestro objetivo fue describir las características clínicas y evolución de los pacientes con Covid-19 grave que requirieron este procedimiento. Evaluar la relación entre factores de riesgo y mortalidad. Materiales y método: Estudio descriptivo retrospectivo observacional. Se incluyeron los pacientes mayores de 18 años con COVID-19 bajo asistencia respiratoria mecánica (ARM) que requirieron DP. Se efectuó seguimiento durante 28 días. Se registraron las complicaciones asociadas al DP. Se analizaron factores asociados a la mortalidad utilizando regresión de Cox. Resultados: Se realizó DP en 28 pacientes. La edad promedio fue de 52.43 años y una mediana de Score de Charlson de 1 [0.00, 2.00]. La mediana de días de ARM fue de 17.00 [RIQ 13.00, 23.00] y un 28,6% logró ser extubado. La mediana de días en UTI fue de 19.50 [RIQ 14.00, 23.50] con una mortalidad del 53,6%. El 35,7% necesito 2 ciclos de DP con una duración predominante de 24-36 hs. El 89,4% tuvo lesiones de UPP. Los que fallecieron tuvieron menos días de UTI (16 vs 28; p=0,006) y solo uno de ellos había logrado ser extubado (1 vs 7, p= 0.011). No se encontraron factores asociados a la mortalidad en la regresión de Cox. Conclusión: La población estudiada resultó predominantemente masculina y de edad promedio cercana a la quinta década de vida, con una mortalidad aproximada al 50%. No se encontró relación estadísticamente significativa entre factores de riesgo y mortalidad.

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“…In the Peruvian population, an association was found with CRP, LDH> 350 UI/L, ferritin> 750 ng/mL, and leukocyte. In addition to D-dimer (> = 1 μg/mL), severe lymphopenia, both in crude and adjusted analyses [ 44 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

Factors associated with mortality in patients hospitalized for COVID-19 admitted to a tertiary hospital in Lambayeque, Peru, during the first wave of the pandemic

et al. 2023

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Introduction COVID-19 caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread worldwide, becoming a long-term pandemic. Objectives To analyze the factors associated with mortality in patients hospitalized for COVID-19 in a tertiary hospital in the Lambayeque region of Peru. Methods A retrospective cohort study of patients with a diagnosis of COVID-19, hospitalized in a hospital in northern Peru, was conducted from March to September 2020. Results Of the 297 patients studied, 69% were women, the mean age was 63.99 years (SD = ±15.33 years). Hypertension was the most frequent comorbidity (36.67%), followed by diabetes mellitus (24.67%) and obesity (8.33%). The probability of survival at 3 days of ICU stay was 65.3%, at 7 days 24.2%, and 0% on day 14. Risk factors associated with mortality in patients hospitalized for COVID-19 are age, male sex, tachypnea, low systolic blood pressure, low peripheral oxygen saturation, impaired renal function, elevated IL-6 and elevated D-dimer. Conclusions Mortality in hospitalized patients with COVID-19 was 51.18 per 100 persons, Mortality was found to be associated with hypertension, type of infiltrating, and sepsis.

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Factors associated with mortality in patients hospitalized with COVID-19: A prospective cohort in a Peruvian national referral hospital

Cited by 16 publications

References 24 publications

Cerebrovascular disease and mortality in hospitalized patients with COVID-19 in a Latin American country, Peru.

Cerebrovascular disease and mortality in hospitalized patients with COVID-19 in a Latin American country, Peru.

Impacto del decúbito prono en pacientes con COVID-19 grave en un hospital de agudos de la Ciudad Autónoma de Buenos Aires.

Factors associated with mortality in patients hospitalized for COVID-19 admitted to a tertiary hospital in Lambayeque, Peru, during the first wave of the pandemic

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