Factors associated with the development of atrial fibrillation in patients with rheumatic mitral stenosis

Abstract

The aim of this study was to evaluate the factors associated with the development of atrial fibrillation (AF) in patients with rheumatic mitral stenosis (MS). A total of 146 consecutive patients with rheumatic MS were screened. They were accepted to be in AF group and sinus rhythm group according to their rhythm in the baseline ECG. After screening, 38 patients were excluded due to hyperthyroidism (n = 13), chronic obstructive pulmonary disease (n = 22), malignancy (n = 2) and rheumatoid arthritis (n = 1). Therefore, remaining 108 patients, 74 of whom in sinus rhythm (MS-SR) and 34 of whom in AF (MS-AF) constituted study population. Fourty age- and gender-matched patients constituted control group. Factors associated with development of AF in multivariable analysis included High sensitivity C reactive protein (P = 0.005; odds ratio, 3.44; 95% confidence interval, 1.44-8.22), N-terminal of brain natriuretic peptide precursor (P < 0.0001; odds ratio, 1.03; 95% confidence interval, 1.02-1.06) and left atrial diameter (P < 0.0001; odds ratio, 1.68; 95% confidence interval, 1.32-2.14). Present study suggests that High sensitivity C reactive protein, N-terminal of brain natriuretic peptide precursor and left atrial diameter are associated with development AF in patients with MS.

Impact of Prosthesis-Patient Mismatch on Late Recurrence of Atrial Fibrillation After Cryomaze Procedure With Mitral Valve Replacement

“…They found that high-sensitivity C-reactive protein, N-terminal brain natriuretic peptide precursor, and LA diameter were associated with development of AF. 22 In the present patients, LA dimension was decreased after operation and did not change in those who did not have high mean MPG. But it was increased after 7 years in patients with high mean MPG ( Figure 2B).…”

Atrial fibrillation and early clinical outcomes after mitral valve surgery in patients with rheumatic vs. non-rheumatic mitral stenosis

“…reported that factors associated with the development of atrial fibrillation in patients with rheumatic mitral stenosis are included high sensitivity to C-reactive protein, N-terminal of brain natriuretic peptide precursor and left atrial diameter. [6] Akram et al . suggested that non-rheumatic mitral stenosis is more frequent than is assumed and is associated with risk factors for coronary artery disease.…”

“…Inflammatory response of the immune system is one of the most important pathogenesis of VHD. [56] Mitral stenosis (MS) is a structural abnormality of the mitral valve apparatus that can result from previous rheumatic fever. Non-rheumatic mitral stenosis may be due to congenital mitral stenosis, malignant carcinoid disease, etc.…”

Evaluation of Atrial Electromechanical Delay and Its Relationship to Inflammation and Oxidative Stress in Patients with Chronic Obstructive Pulmonary Disease

“…In recent years, inflammation and oxidative stress have been shown to be associated with AF in different patient populations. 5,6,23,24 The prolongation of atrial electromechanical delay is an important electrophysiological parameter associated with new onset and/or recurrence of AF. 11,12 Atrial conduction time can be measured accurately through invasive methods.…”