Factors Influencing Methoxsalen Phototoxicity in Vitiliginous Skin

Arora, Surinder K.

doi:10.1001/archderm.1976.01630270007002

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Genetic and Congenital Disorders1

Introduction1

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1979

2005

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Cited by 8 publications

(2 citation statements)

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“…The problems with use are considerable. Topical psoralens are extremely phototoxic, but the degree is a function of concentration [686]. As little as 2.5 IJ.g/sq in.…”

Section: Genetic and Congenital Disordersmentioning

confidence: 99%

Vitiligo and Other Hypomelanoses of Hair and Skin

Ortonne¹,

Mosher²,

Fitzpatrick³

1983

139

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“…The problems with use are considerable. Topical psoralens are extremely phototoxic, but the degree is a function of concentration [686]. As little as 2.5 IJ.g/sq in.…”

Section: Genetic and Congenital Disordersmentioning

confidence: 99%

Vitiligo and Other Hypomelanoses of Hair and Skin

Ortonne¹,

Mosher²,

Fitzpatrick³

1983

139

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“…These compounds are of economical value as they are used in dermatological preparation for different skin diseases. They have been prominent in the United States for their role in photochemotherapy (PUVA) of vitiligo (6)(7)(8) , psoriasis (9)(10)(11) , Parapsoriasis, Mycosis fungoides (12)(13)(14) . Recently some other biological activities of Psoralens and related compounds have been reported; these include: having antiinflammatory and analgesic activities (15) , antitumor activity (16) , having calcium antagonist properties (17) .…”

Section: Introductionmentioning

confidence: 99%

Qualitative and Quantitative investigations of Furocoumarin derivatives (Psoralens) of Haplophyllum tuberculatum (Rutaceae)

Diar¹,

Enas²,

Ekbal³

et al. 2005

AJPS

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Haplophyllum tuberculatum is an indigenous plant widely distributed in Iraq.Phytochemical investigation of this plant indicating that the plant is rich in alkaloids, fixed and volatile oils; but non about psoralen contents. Preliminary investigation indicated that this plant has furocoumarins in acceptable amount.Based on these results together with literature survey it was deemed desirable to carry out this phytochemical work with emphasis on isolation and characterization of the furocoumarins compounds.Detailed preliminary investigation of the furocoumarins content of the dried, ground whole plant has been described and the results were discussed.Thin layer chromatography of the petroleum ether (boiling point 60-80ºC) extract demonstrated the occurance of furocoumarins compounds in the plant.The extraction procedure of the plant material, the fractionation and isolation procedures of the furocoumarins are fully described.One compound was isolated and identified as Ammoidin by TLC (compared with standard), melting point (148°C), mixed melting point (148ºC) and HPLC.Spectrophotometer apparatus was used to determine exactly the amount of Ammoidin measured at 304nm at UV absorption. In Haplophyllum tuberculatum the maximum amount of Ammoidin was found in sample collecting from Daquok during June.

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