Vitiligo and Other Hypomelanoses of Hair and Skin

Ortonne, Jean‐Paul; Mosher, David B.; Fitzpatrick, Thomas B.

doi:10.1007/978-1-4615-9272-3

Cited by 139 publications

(93 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Three clinical patterns of ND are described: isolated, segmental, and whorled types. 2,7,[11][12][13] However, differentiating whorled ND from hypomelanosis of Ito is rather vague and there are controversies about differences between these two entities. 6,14 In contrast to ND, hypomelanosis of Ito shows a familial tendency and is usually associated with systemic abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Clinical and histopathologic characteristics of nevus depigmentosus

Kim

Kang

Lee

et al. 2006

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Clinical and histopathologic characteristics of nevus depigmentosus

Kim

Kang

Lee

et al. 2006

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

“…Indeed, one disorder, human piebald trait, is very similar to mouse dominant spotting and is characterized by autosomal dominant inheritance, a white hair forelock, stable areas of hypopigmentation or "leukoderma" on the anterior chest and extremities, and the absence of extracutaneous manifestations (10). In addition, cytogenetic data have implicated the long arm of chromosome 4, a region that includes the human c-kit gene (7,11,12), in the pathogenesis of piebald trait in three children with large interstitial deletions and multiple congenital anomalies (13).…”

mentioning

confidence: 99%

Deletion of the c-kit protooncogene in the human developmental defect piebald trait.

Fleischman

Saltman

Stastny

et al. 1991

Proc. Natl. Acad. Sci. U.S.A.

184

View full text Add to dashboard Cite

The protooncogene c-kit is critical for development of hematopoietic stem cells, germ cells, and melanoblasts in the mouse. Homozygous mutations of this gene in the mouse cause anemia, infertility, and albinism, whereas heterozygous mutant mice usually exhibit only a white forehead blaze and depigmentation of the ventral body, tail, and feet. The heterozygous mouse phenotype is very similar to human piebald trait, which is characterized by a congenital white hair forelock and ventral and extremity depigmentation. To investigate the possibility that alterations in the human c-kit gene may be a cause of piebald trait, DNA from seven unrelated affected individuals was examined by Southern blot analysis. One subject, although cytogenetically normal, has a heterozygous deletion of the c-kit protooncogene. This deletion encompasses the entire coding region for c-kit and also involves the closely linked gene for platelet-derived growth factor receptor alpha. Fluorescence in situ hybridization of genomic c-kit probes to metaphase chromosomes independently confirmed the deletion in this case. These findings provide molecular evidence mapping piebald trait to the c-kit locus on chromosome 4. Although we cannot exclude the involvement of other closely linked genes, the demonstration of a genomic c-kit deletion in one subject with piebald trait and the marked concordance of the human and mouse phenotypes provide strong evidence for the role of c-kit in the development of human melanocytes and in the pathogenesis of piebald trait.

show abstract

“…Electron microscopic studies show signs of degeneration of melanocytes and absence of melanocytes in long standing cases. 7,8 Studies demonstrated that peripheral damage to keratinocytes and melanocytes suggesting that a cytotoxic agent is directed towards these cells. 7 Presence of melanocytes in the basal layer of the epidermis on left side of the lesion, whereas decreased melanocytes in the basal layer of the epidermis on the right side of the same lesion in the present study.…”

Section: Discussionmentioning

confidence: 99%

A study on histopathological changes in lesions of vitiligo in Karnataka population

Nagaral¹,

Karibasappa

2017

Int J Res Dermatol

View full text Add to dashboard Cite

Background: Vitiligo is considered to be symptom less and its presentation is boundless varying from isolated focal lesion to bizarre generalized lesions. The present study was undertaken to study the histopathological changes in lesions of vitiligo in south Indian population.Methods: 150 patients with mild to moderate vitiligo features attending the outpatient department of Dermatology, Venereology and Leprology at Chitageri General Hospital and Bapuji Hospital attached to J.J.M Medical College, Davengere were utilized to study the histopathological features in vitiligo and its association with other diseases.Results: Destruction of melanocytes at dermo-epidermal junction was noted. We have observed presence of melanocytes in the basal layer of the epidermis on left side of the lesion, whereas decreased melanocytes in the basal layer of the epidermis on the right side of the same lesion in the present study. Dermis with mild perivascular lymphocytic infiltration and acanthosis along with mono nuclear cell infiltration in the upper dermis was observed. Conclusions: The present study gives better knowledge to the clinicians about the lesions of vitiligo and its pathogenesis.

show abstract

Vitiligo and Other Hypomelanoses of Hair and Skin

Cited by 139 publications

References 76 publications

Clinical and histopathologic characteristics of nevus depigmentosus

Clinical and histopathologic characteristics of nevus depigmentosus

Deletion of the c-kit protooncogene in the human developmental defect piebald trait.

A study on histopathological changes in lesions of vitiligo in Karnataka population

Contact Info

Product

Resources

About