Factors influencing reproduction in captive‐bred cynomolgus monkeys (<i>Macaca fascicularis</i>) from Mauritius

Naiken, Sandiren; Griffiths, Mary-Ann; Edouard, Lindsay; Padayatchy, Nada

doi:10.1002/ajp.22482

Cited by 3 publications

(6 citation statements)

References 54 publications

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“…One 0.15 mg/kg/day female infant was vaginally delivered pre-term (<150 days) and had the lowest birthweight at 240 grams. The remaining infants exhibited birthweights and anthropometric measures consistent with normal full-term newborns for this species (Burbacher et al, 1988;Naiken et al, 2015) Preliminary two-way ANOVAs were run to examine whether or not gestation length impacted birthweights or anthropometric measures. The results of these analyses did not indicate a significant main effect of gestation length or DA exposure on any of the newborn parameters (p>0.10, all tests), or an interaction of gestation length and DA exposure (p>0.10, all tests).…”

Section: Newborn Proceduresmentioning

confidence: 99%

Effects of oral domoic acid exposure on maternal reproduction and infant birth characteristics in a preclinical nonhuman primate model

Burbacher

Grant

Petroff

et al. 2019

Neurotoxicology and Teratology

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Domoic Acid (DA) is a naturally-occurring excitotoxin, produced by marine algae, which can bioaccumulate in shellfish and finfish. The consumption of seafood contaminated with DA is associated with gastrointestinal illness that, in the case of high DA exposure, can evolve into a spectrum of responses ranging from agitation to hallucinations, memory loss, seizures and coma. Because algal blooms that produce DA are becoming more widespread and very little is known about the dangers of chronic, low-dose exposure, we initiated a preclinical study focused on the reproductive and developmental effects of DA in a nonhuman primate model. To this end, 32 adult female Macaca fascicularis monkeys were orally exposed to 0, 0.075 or 0.15 mg/kg/day DA on a daily basis, prior to and during pregnancy. Females were bred to non-exposed males and infants were evaluated at birth. Results from this study provided no evidence of changes in DA plasma concentrations with chronic exposure. DA exposure was not associated with reproductive toxicity or adverse changes in the physical characteristics of newborns. However, in an unanticipated finding, our clinical observations revealed the presence of subtle neurological effects in the form of intentional tremors in the exposed adult females. While females in both dose groups displayed increased tremoring, the effect was dose-dependent and observed at a higher rate in females exposed to 0.15 mg/kg/day. These results demonstrate that chronic, low-level exposure to DA is associated with injury to the adult CNS and suggest that current regulatory guidelines designed to protect human health may not be adequate for high-frequency shellfish consumers.

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Section: Newborn Proceduresmentioning

confidence: 99%

Effects of oral domoic acid exposure on maternal reproduction and infant birth characteristics in a preclinical nonhuman primate model

Burbacher

Grant

Petroff

et al. 2019

Neurotoxicology and Teratology

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“…This finding agrees with previous studies, in which 60–70% of the infant deaths occurred in the first 3 months (Itoigawa et al 1992 ; Koyama et al 1992 ; Watanabe et al 1992 ). Furthermore, our data indicate that infant mortality is higher among primiparous than multiparous females ( Macaca fuscata: Itoigawa et al 1992 ; Macaca fascicularis: Naiken et al 2015 ; Macaca mulatta: Bercovitch et al 1998 ). This might reflect the fact that first time mothers are less experienced in rearing offspring (Sugiyama and Ohsawa 1982 ).…”

Section: Discussionmentioning

confidence: 64%

“…In only eight birth seasons were more males than females born. In , 2007In , and 2015, the values were equal.…”

Section: Birth Sex Ratiomentioning

confidence: 99%

“…Information on male social rank was provided from previous research results using established protocols for behavioral observations of dyadic interactions between males collected in the mating period of 2012 (Pflüger et al 2014, 2016), 2015, and (Herzele 2017. In these studies, dominant (e.g., chase, threat, spatial displacement, physical attacks) and submissive (e.g., flee, fear grin, avoidance) behaviors were used to assess the proportion of encounters "won" by an animal against another in a pairwise interaction (Singh et al 2003).…”

Section: Social Statusmentioning

confidence: 99%

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Twenty-three-year demographic history of the Affenberg Japanese macaques (Macaca fuscata), a translocated semi-free-ranging group in southern Austria

et al. 2021

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Demographic studies on translocated primate groups provide a unique opportunity to study population dynamics, social strategies, and reproductive parameters of a species adapting to new environments. In 1996, 38 Japanese macaques (Macaca fuscata) of the Minoo-H group (Osaka Prefecture, Japan) were translocated to Affenberg Landskron, a four-hectare naturally forested park in southern Austria. By January 2020, the population had increased to 160 individuals, and a total of 223 births were recorded. Births peaked in late April to late May, and the timing was influenced by neither offspring sex nor parity status of the mother. Infant mortality was low (8.97%), mostly involving primiparous females, and the average interbirth intervals were shorter following the death of an infant (1.10 years) than a surviving infant (1.77 years). Females rarely had offspring with the same males repeatedly, and the reproductive success among males declined with increasing years of presence in the group. The main aspects of reproduction, mortality, and mate choice are consistent with published data on natural and provisioned populations in Japan and those translocated to other countries. The life expectancy for females, however, was relatively high (11.72% chance of reaching the age of 20), whereas birth control prevented them from using their lifetime reproductive potential. By January 2020, the number of old individuals (> 18 years; 17.5%) was close to that of juveniles (< 4 years; 22.5%). The specific group composition, along with the inability of males to emigrate out of their natal group, may affect the social dynamics of the population, which merits further attention in future studies.

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“…In some primates, including humans, fetus growth is known to be affected by maternal age, parity, body size and nutritional status, and the sex of the fetus (7)(8)(9)(10). The purpose of this study is to determine the factors that influence the growth of fetal body weight (FBW) and fetal head size (FHS) relative to CRL.…”

Section: Introductionmentioning

confidence: 99%

Influence of radiation exposure to delayed fetal growth in wild Japanese monkeys after the Fukushima accident

et al. 2023

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Wild Japanese monkeys (Macaca fuscata) were exposed to radiation after the Fukushima Daiichi nuclear accident in 2011. To clarify the biological effects of radiation exposure on their fetal growth, pregnant monkeys and their fetuses were analyzed. These animals were collected between 2008 and 2020 (before and after the accident in 2011) living in Fukushima City, approximately 70 km from the nuclear power plant. Multiple regression analyses were conducted with fetal body weight (FBW) and fetal head circumference (FHS) as objective variables, and maternal and fetal factors as explanatory variables. The maternal factors were relative exposure dose rate (REDR), age, body weight, body length, fat index, and parity. The fetal factors were crown ramp length (CRL) and sex. Multiple regression analyses showed that FBR and FHS growth were positively associated with CRL, maternal body length, and negatively associated with REDR. Since the relative growth of FBR and FHS to CRL decreased with increasing REDR, radiation exposure due to the nuclear accident may have contributed to the delayed fetal growth observed in Japanese monkeys.

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Factors influencing reproduction in captive‐bred cynomolgus monkeys (Macaca fascicularis) from Mauritius

Cited by 3 publications

References 54 publications

Effects of oral domoic acid exposure on maternal reproduction and infant birth characteristics in a preclinical nonhuman primate model

Effects of oral domoic acid exposure on maternal reproduction and infant birth characteristics in a preclinical nonhuman primate model

Twenty-three-year demographic history of the Affenberg Japanese macaques (Macaca fuscata), a translocated semi-free-ranging group in southern Austria

Influence of radiation exposure to delayed fetal growth in wild Japanese monkeys after the Fukushima accident

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