Factors influencing treatment default among tuberculosis patients in a high burden province of South Africa

Kigozi, Gladys; Heunis, Christo; Chikobvu, Perpetual; Botha, Sonja; Rensburg, Dingie van

doi:10.1016/j.ijid.2016.11.407

Cited by 64 publications

(78 citation statements)

References 31 publications

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“…21 Outros autores também têm encontrado associação de faixas etárias mais elevadas com óbito, porém para o desfecho abandono tem sido descrita associação com faixa etária de adulto jovem, relacionada talvez a fatores sociais, etilismo e drogas. 8,9,20,22,23 A raça/cor de pele referida como não branca apresentou 1,6 vezes mais chances de ter o desfecho desfavorável em relação à branca. O Relatório Anual das Desigualdades Raciais no Brasil 2009-2010 mostra a diminuição da qualidade de vida e da expectativa de vida da população negra, e maiores chances de incidência e óbito por tuberculose entre pardos e negros além de menor acesso a serviços de saúde.…”

Section: Fatores Associados Ao óBito E Ao Abandono Do Tratamento Da Tunclassified

“…12 Outros autores também relataram associação entre retratamento e desfecho desfavorável (óbito por tuberculose, abandono ou falência). 9,15,22,24,25 O uso de álcool e drogas ilícitas é apontado por vários autores como fatores relacionados ao abandono do tratamento. 5,15,20 Neste estudo, o alcoolismo e uso de drogas ilícitas estiveram associados a um desfecho desfavorável na análise bivariada; na multivariada não alcançaram significância, embora a razão de chances associada ao uso de drogas ilícitas permanecesse elevada.…”

Section: Fatores Associados Ao óBito E Ao Abandono Do Tratamento Da Tunclassified

“…3,[5][6][7] O abandono do tratamento tem sido relacionado a fatores relacionados à medicação, ao doente e a fatores relacionados aos serviços de saúde. 5,[8][9][10][11] As consequên-cias da não adesão ao tratamento são diversas: redução da taxa de cura; óbito por tuberculose; desenvolvimento de formas clínicas mais graves e a multirresistência aos tuberculostáticos. A coinfecção pelo vírus da imunodeficiência humana (HIV) é outro relevante fator associado a desfecho desfavorável.…”

Section: Introductionunclassified

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Fatores associados ao desfecho desfavorável do tratamento da tuberculose em um hospital geral do município do Rio de Janeiro, 2007 a 2014

Pereira

Escosteguy

Gonçalves

et al. 2018

Rev Epidemiol Control Infect

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Exceto onde especificado diferentemente, a matéria publicada neste periódico é licenciada sob forma de uma licença Creative Commons -Atribuição 4. estudo observacional, analítico, de todos os 670 casos confirmados notificados neste período na base local do Sistema de Informação de Agravos de Notificação (SINAN), com encerramento registrado como cura (383), óbito por tuberculose (159) ou abandono do tratamento (128). Este sistema é alimentado a partir de ficha de investigação epidemiológica padronizada, contendo variáveis sociodemográficas e clínicas. A análise estatística envolveu variáveis disponíveis no SINAN e considerou desfecho desfavorável aquele composto por óbito ou abandono. Variáveis com razões de chances elevadas na análise bivariada e/ou importância clínica foram consideradas para inclusão em modelo multivariado de regressão logística. Como medida de associação para análise dos fatores associados a desfecho desfavorável versus cura, foram estimadas as razões de chance e seus intervalos de 95% de confiança. Resultados: foram identificados como fatores estatisticamente associados a chance aumentada do desfecho desfavorável idade ≥60 anos, raça/cor não branca, tratamento prévio para tuberculose ou situação de tratamento prévio desconhecida, resultado de anti-HIV positivo, forma pulmonar e sobretudo forma extrapulmonares grave. Conclusão: esses resultados reforçam a necessidade de investir em políticas que garantam o acesso e a adequada assistência aos pacientes, especialmente àqueles com condições que predispõem a não adesão ao tratamento e formas graves. Descritores: Tuberculose. Vigilância Epidemiológica. Resultado de Tratamento. Modelos Logísticos.Background and Objectives: tuberculosis remains a relevant public health problem and the cure of diagnosed cases is a strategy to reduce high morbidity and mortality. The objective of our study is to identify factors associated with death due to tuberculosis and treatment default in patients diagnosed in the HFSE from 2007 to 2014. Methods: we conducted an observational, analytical study of all 670 confirmed cases reported in this period at the local SINAN reporting base, whose outcome was registered as cure (383)

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Section: Fatores Associados Ao óBito E Ao Abandono Do Tratamento Da Tunclassified

Section: Introductionunclassified

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Fatores associados ao desfecho desfavorável do tratamento da tuberculose em um hospital geral do município do Rio de Janeiro, 2007 a 2014

Pereira

Escosteguy

Gonçalves

et al. 2018

Rev Epidemiol Control Infect

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“…7 Although these initiatives contribute greatly to the management of TB, several studies carried out in Nigeria and other countries have presented TB related challenges. [8][9][10] This includes patients' related factors such as inadequate TB knowledge as well as perceptions and attitude towards treatment. [10][11][12] Consistently, inadequate knowledge of TB treatment especially treatment duration has been associated with treatment interruption.…”

Section: Introductionmentioning

confidence: 99%

Knowledge, attitude and perception of tuberculosis management among tuberculosis-infected patients in resource constraint setting: field experience from Oyo state, South-West, Nigeria

Oladimeji

Tsoka-Gwegweni

Adeyinka

et al. 2018

Int J Community Med Public Health

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Background: Inadequate knowledge and misconceptions about tuberculosis (TB) contribute to the burden of the disease by influencing patients' behavior and attitude towards the disease and undermining infection control efforts. This study assesses the level of knowledge, attitude and perception of TB and its management among TB-infected patients. Methods: A descriptive cross-sectional was used to interview 712 TB patients using a semi-structured questionnaire between June and October 2016. Bivariate and multivariate analyses were performed with SPSS version 20. Results: About 70% had a good knowledge of TB. Patients' perception of stigma was high (37.5%). A high proportion of the patients had a poor perception of their illness (88%). Healthcare workers attitude was rated as satisfactory by 97.2% of respondents. Patients who had good knowledge about TB experienced high self-stigma (42%) compared to those who had poor knowledge (27.2%), p<0.05. Poor knowledge of TB was highest among relapse TB cases. Respondents with poor TB knowledge were less likely to be male (OR: 0.66; 95% CI: 0.46, 0.95), married (OR: 0.24; 95% CI: 0.10, 0.55; p=0.001) and have tertiary education (OR: 0.06; CI: 0.37, 0.87; p=0.010). Patients with good knowledge about HIV and in the richest wealth status were 91% less likely to have high perceived stigma (OR: 0.09, 95%CI: 0.02, 0.35; p=0.001). Conclusions:The level of knowledge of TB among patients is satisfactory, however perception of illness is poor. Tuberculosis diagnosis can create self-stigma because of the fear of being isolated and discriminated which may determine the success of treatment.

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“…Ketika penderita TB tidak melaksanakan pengobatan secara tuntas, maka akan terjadi mutase genetik kuman M. tuberculosis menjadi kuman M.Tb yang resisten terhadap OAT (Kigozi et al, 2017).…”

Section: Efek Samping Obatunclassified

Evaluation of Multi-Drug Resistant Tuberculosis Predictor Index in Surakarta, Central Java

Pamungkas

Rahardjo

Murti

2018

J EPIDEMIOL PUBLIC HEALTH

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Background: Tuberculosis (TB) remains a global public health problem. New cases of lung Tuberculosis in 2015 were 10.4 million worldwide. One of the challenging in TB control to be addressed is the development of Multi Drug Resistant Tuberculosis (MDR-TB). There were an estimated 15,380 TB cases in Indonesia by 2015 with 1,860 positive TB cases and 1,566 cases successfully treated. This study aimed to determine the predictor index for MDR-TB. Subjects and Method:This was an analytic observational study with a case-control design. The study was conducted at Dr. Moewardi Hospital, Surakarta, Central Java, from August to November 2017. The study subjects were selected by fixed disease sampling including 75 MDR-TB patients and 75 TB patients. The dependent variable was MDR-TB. The independent variables were medical history, co-morbidity (Diabetes Mellitus), drug side effect, drug-taking supervisor, and regularity of treatment. The data were collected by questionnaire and medical record. The data were analyzed by a multiple logistic regression. Results: MDR-TB Occurrence Index increased with drug-taking supervisor (b = 2.33; 95% CI= 3.83 to 27.91; p<0.001), drug-side effect (b = 0.73; 95% CI= 0.58 to 7.45; p=0.026), medical history (b = 2.35; 95% CI= 3.80 to 29.38; p<0.001). MDR-TB Occurrence Index decreased by absence of type 2 Diabetes Mellitus (b = -0.56; 95% CI= 0.18 to 1.78; p= 0.033), regular treatment (b = -1.73; 95% CI= 0.06 to 0.46; p<0.001). Conclusion: MDR-TB Occurrence Index is determined by drug-taking supervisor, drug-side effect, medical history, Type 2 Diabetes Mellitus, and regular treatment.

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Factors influencing treatment default among tuberculosis patients in a high burden province of South Africa

Cited by 64 publications

References 31 publications

Fatores associados ao desfecho desfavorável do tratamento da tuberculose em um hospital geral do município do Rio de Janeiro, 2007 a 2014

Fatores associados ao desfecho desfavorável do tratamento da tuberculose em um hospital geral do município do Rio de Janeiro, 2007 a 2014

Knowledge, attitude and perception of tuberculosis management among tuberculosis-infected patients in resource constraint setting: field experience from Oyo state, South-West, Nigeria

Evaluation of Multi-Drug Resistant Tuberculosis Predictor Index in Surakarta, Central Java

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