Factors influencing yield of platelet aphaeresis using continuous flow cell separator

Patel, Jitendra N.; Nishal, Arpita; Pandya, Amrish N; Patel, Prashant J; Wadhwani, Sangita

doi:10.5455/ijmsph.2013.2.323-326

Cited by 5 publications

(8 citation statements)

References 12 publications

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“…while DasSS et al &Chaudhary R et al had observed no correlation of predonation haemoglobin concentration of the donor with yield (r = -0.05 & r = -0.1 respectively, P >0.005). 9,10 No such correlation was observed in the present study(r=0.0 22, p>0.05) which is similar to the observation by Patel J et al (r = -0.001, P > 0.005),Das SS et al &Chaudhary R et al5,9,10 while Enein AA et al found that yield negatively correlated with donor pre-aphaeresis haemoglobin (r = -0.306) 11. …”

supporting

confidence: 87%

“…Another donor factor that may have an influence on the platelet yield is pre-donation haemoglobin concentration, which has an inverse relationship with the yield in study done by Guerrero-Rivera et al 6 The present study showed correlation of height 5,11 ; however increasing the processing time, the ACD infusion rate, or the volume of plasma obtained with platelet can increase platelet yields. 11 The present study also showed a correlation between donor's total volume processed & yield (r=-0.648, p<0.001).…”

Section: Discussionmentioning

confidence: 41%

“…11 A direct relationship was observed between pre-donation platelet count and yield (r = 0.50, P < 0.001) by ChaudharyR et al 10 Patel J et al performed 265 procedures and found a direct positive correlation between the platelet yield and pre-donation platelet count(r=0.302,p< 0.0001). 5 In our study,mean pre donation platelet count was 244.14 ± 55.83 per µl which resulted in platelet product with yield of 3.34 ± 0.327 x 10 11 . Results of present study were also in accordance with the observations by various studies conducted all over the world.…”

Section: Discussionmentioning

confidence: 50%

“…1 In India, because of economic constraints & limited resources, SDP is not in that much demand till date. 5 Platelet recovery in the patient is influenced by the transfused dose of platelets, which in turn is dependent on the quality of SDP in terms of platelet yield. 6 Donor platelet count has a direct impact on the yield of platelets.…”

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confidence: 99%

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Influence of donor demographics on the platelet yield during plateletpheresis - experience of 1100 procedures at a tertiary-care hospital

Mangwana¹

2014

J Pathol Nep

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Background: Transfusion of plateletpheresis is effective for treating patients with platelet related insufficiencies while limiting recipient'sexposure to platelets from multiple donors. A larger yield is obtained when donor has a greater number of initial platelets and separation done in a shorter time. The aim of the study was to analyze the effect of various donors and procedure related parameters on the yield of single donor platelet so that blood donors can be screened effectively in less time. Materials and Methods:One thousand and one hundred plateletpheresis procedures were performed in a tertiary-care super-specialty hospital onFenwal AMICUS machine using closed system kits. Statistical analysis was done to establish cause and effect relationship and to find the extent of relationship between different variables.Results: Height, weight,BMI, platelet count and total leucocyte count had significant correlation with platelet yield, processing time and blood volume processed while haemoglobin especially in females correlated significantlywith processing time(p<0.0001)and blood volume processed. Rh "negative" donors had shorter processing time than Rh "positive" donors while ABO group did not show any correlation with machine variables. Conclusion:Platelet yield correlated positively with pre-donation count, height, weight and BMI. Haemoglobin correlated with processing time and blood volume processed. Optimization of platelet yield is an emerging issue to identify factors which may help in selecting donors to obtain higher platelet yields in shorter time and consequently better clinical outcome.

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supporting

confidence: 87%

Section: Discussionmentioning

confidence: 41%

Section: Discussionmentioning

confidence: 50%

mentioning

confidence: 99%

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Influence of donor demographics on the platelet yield during plateletpheresis - experience of 1100 procedures at a tertiary-care hospital

Mangwana¹

2014

J Pathol Nep

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“…6 Data from the American Red Cross also showed a lower risk of transfusion reaction due to bacterial contamination from plateletpheresis rather than to platelet concentrates. 7,8 Although gradually increasing, plateletpheresis is still quite new in Indonesia and rarely performed. This pattern is caused by several factors; the aphaeresis machine is quite expensive, and there are limited aphaeresis donors due to the predonation terms and conditions that have to be fulfilled by the donors.…”

Section: Introductionmentioning

confidence: 99%

Factors influencing plateletpheresis donations in Dr. Sardjito General Hospital, Yogyakarta, Indonesia

2018

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Despite its life saving potential, regrettably, blood transfusion has yet to be optimally applied in Indonesia. Funding difficulties and both public and professional lack of knowledge hinders its progress. More lives can be saved by using a safer, more proper, and specialized blood transfusion procedure. Plateletpheresis, one method to obtain platelet products, requires a different donation procedure than that of whole bloodderived platelet. High quality plateletpheresis product donation will positively impact the transfusion efficacy and platelet recovery of the recipient, improving patient's clinical state. This study analyzes factors from both the donor and donation procedure that influence the quality of plateletpheresis product. The study analyzes data of plateletpheresis donations from blood transfusion service and plateletpheresis transfusions from medical records at Dr. Sardjito General Hospital, Yogyakarta, Indonesia, within the period of August 2012 to January 2013 using cross sectional design. Forty-four plateletpheresis donations were obtained during the study. All donors were male with the following mean values; age 31.9 ± 9.9 years, weight 70.2 ± 10.2 kg, body mass index (BMI) 24.7 ± 3.2 kg/m2, hematocrit 44 ± 3.2 %, and procedure time 84.2 ± 19.2 min. The median value of platelet yield was 3.2x10 11 (2.1x10 11-4x10 11). The median value of pre-donation platelet count was 248.5x10 3 /μL (204x10 3 /μL-391x10 3 /μL) and the mean value of product volume was 275 ± 22.9 mL. The results showed that pre-donation platelet count (r = 0.329; p < 0.05) and product volume (r = 0.661; p < 0.05) positively correlated to the yield of platetetpheresis products. However, the yield of plateletpheresis products was not correlated to the posttransfusion platelet count (r = 0.327; p > 0.05). In conclusion, pre-donation platelet count and product volume of plateletpheresis influence the yield of plateletpheresis. However, the yield is not correlated to the post-donation platelet count. Thus, other clinical factors should be considered.

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A Study on Influence of Donor Hematocrit on the Procedural Parameters of Concentrated Single Donor Platelets Collected by Two Apheresis Devices

Chellaiya

Murugesan

Nayanar

2019

Indian J Hematol Blood Transfus

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With improvements in apheresis collection, platelet additive solution (PAS) is steadily replacing plasma as the storage medium in single donor platelets (SDP). Concentrating platelets in SDP with one-third of plasma and two-thirds of PAS is referred as Concentrated-SDP (C-SDP). We studied the influence of donor hematocrit (Hct) in C-SDP procedures. A retrospective study, consisting of 124 and 95 plateletpheresis donors in MCS? and Trima respectively. We compared two apheresis equipments MCS? and Trima with regard to donor hematocrit on procedural parameters such as collection efficiency (CE), collection rate (CR), yield per hour (Y/H), yield per litre (Y/L) and percentage blood volume processed (%BV) during C-SDP procedures. Donors were categorized into two groups with Group A (Hct B 46%) and Group B (Hct [ 46%) based on mean baseline Hct of the study population. Among the 219 procedures, the overall CE was significantly higher for Trima over MCS? equipment (77 vs 56, P \ 0.001). However, there was no difference in procedural outcomes like CE, Y/L, Y/H, CR with MCS? or Trima equipment between groups. %BV processed had a negative correlation with hematocrit in MCS? (r = -0.305, P = 0.001) and no difference was observed with Trima equipment. Donor Hct influences C-SDP collection only in processed blood volume with MCS? equipment. Trima had statistically better performance over MCS? equipments in all procedural parameters during C-SDP procedures. The data will guide apheresis centre to choose equipments based on donor characteristics.

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Factors influencing yield of platelet aphaeresis using continuous flow cell separator

Cited by 5 publications

References 12 publications

Influence of donor demographics on the platelet yield during plateletpheresis - experience of 1100 procedures at a tertiary-care hospital

Influence of donor demographics on the platelet yield during plateletpheresis - experience of 1100 procedures at a tertiary-care hospital

Factors influencing plateletpheresis donations in Dr. Sardjito General Hospital, Yogyakarta, Indonesia

A Study on Influence of Donor Hematocrit on the Procedural Parameters of Concentrated Single Donor Platelets Collected by Two Apheresis Devices

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