Faecal calprotectin: a marker of inflammation throughout the intestinal tract

Summerton, C B; Longlands, M. G.; Wiener, K; Shreeve, David R

doi:10.1097/00042737-200208000-00005

Cited by 166 publications

(96 citation statements)

References 18 publications

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“…In any event, calprotectin has been viewed as a good clinical marker for diagnosis, since there is a tendency for an increase in extracellular calprotectin correlate with the inflammatory state of a disease. [44][45][46] The next important problem is what type of cells contribute to extracellular calprotectin as the source of the factor. To answer this, we studied the course of intracellular and extracellular calprotectin expression of inflammatory cells using a rat peritonitis model.…”

Section: Pathological States In Which Calpro-tectin Is Upregulatedmentioning

confidence: 99%

Calprotectin (S100A8/S100A9), an Inflammatory Protein Complex from Neutrophils with a Broad Apoptosis-Inducing Activity

Yui

Nakatani

Mikami

2003

Biological & Pharmaceutical Bulletin

283

211

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Calprotectin, a complex of two calcium-binding proteins that belong to the S100 protein family, is abundant in the cytosolic fraction of neutrophils. A high level of calprotectin reportedly exists in extracellular fluid during various inflammatory conditions, such as rheumatoid arthritis, cystic fibrosis and abscesses. However, the exact biological role(s) of the factor is now under investigation. We recently observed that neutrophils contain a factor that shows growth-inhibitory and apoptosis-inducing activities against various cell types including tumor cells and normal fibroblasts, and we identified that factor as calprotectin. The findings suggest that calprotectin exerts a regulatory activity in inflammatory processes through its effect on the survival or growth states of cells participating in the inflammatory reaction. It is also possible that calprotectin, at a high concentration, might have a deleterious effect on fibroblasts and influence the recovery of inflammatory tissue. Therefore, the protein factor may be a new drug target to control inflammatory reactions. We found that a few of the Amaryllidaceae alkaloids effectively inhibited the growth-inhibitory and apoptosis-inducing activities of calprotectin. In this article, we focus on the biological functions of calprotectin in extracellular fluids, focusing on its apoptosis-inducing activity.

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Section: Pathological States In Which Calpro-tectin Is Upregulatedmentioning

confidence: 99%

Calprotectin (S100A8/S100A9), an Inflammatory Protein Complex from Neutrophils with a Broad Apoptosis-Inducing Activity

Yui

Nakatani

Mikami

2003

Biological & Pharmaceutical Bulletin

283

211

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“…Like previous studies of the same design, we did not include patients with GI-associated inflammation or nonmalignant tumors since fecal calprotectin level may increase in these conditions (Summerton et al, 2002;Hoff et al, 2004;Fagerberg et al, 2005). Meanwhile, our findings demonstrated an abnormal distribution of fecal calprotectin level in CRC and gastric cancer patients.…”

Section: Discussionmentioning

confidence: 55%

Diagnostic Value of Fecal Calprotectin as a Screening Biomarker for Gastrointestinal Malignancies

Khoshbaten¹,

Pishahang²,

Nouri³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Calprotectin in feces seems to be a more sensitive marker for gastrointestinal (GI) cancers than fecal occult blood, but its specificity may be too low for screening average risk populations. This study aims at evaluating the diagnostic value of fecal calprotectin as a screening biomarker for GI malignancies. Materials and Methods: In a case-control study, 100 patients with GI malignancies (50 patients with colorectal cancer and 50 patients with gastric cancer) and 50 controls were recruited in Tabriz 3) in gastric cancer, colorectal cancer and control group, respectively, the differences being significant (p<0.001) and remaining after adjustment for age. The optimal cut-off point for fecal calprotectin was ≥75.8µg/g for distinguishing colorectal cancer from normal cases (sensitivity and specificity of 80% and 84%, respectively). This value was ≥41.9µg/g for distinguishing gastric cancer from normal cases (sensitivity and specificity of 62%). Conclusions: Our results revealed that fecal calprotectin might be a useful and non-invasive biomarker for distinguishing colorectal cancer from non-malignant GI conditions. However, due to low sensitivity and specificity, this biomarker may not help physicians distinguishing gastric cancer cases from healthy subjects.

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“…The findings and the diagnosis in the other 37 patients were not discussed. Though previous studies have shown a good correlation between FC and the degree of inflammation in patients with inflammatory bowel disease [7][8][9], it's correlation in this heterogenous group is unknown. The authors allowed a 30-day gap between the capsule study and FC measurement, and while relatively short, it may influence results.…”

mentioning

confidence: 88%

“…Unlike the CE scoring indices, several studies have shown an excellent correlation of FC with the severity of mucosal inflammation [7,8]. There are many studies that confirm that FC can differentiate inflammatory from non-inflammatory gastrointestinal disorders, including small bowel inflammation [8,9]. Therefore, many consider FC a ''gold standard,'' reliable and highly specific marker of inflammation.…”

mentioning

confidence: 99%

Correlation of Two Capsule Endoscopy Scoring Systems with Fecal Calprotectin: Does It Really Matter?

Gurudu

Leighton

2012

Dig Dis Sci

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Faecal calprotectin: a marker of inflammation throughout the intestinal tract

Cited by 166 publications

References 18 publications

Calprotectin (S100A8/S100A9), an Inflammatory Protein Complex from Neutrophils with a Broad Apoptosis-Inducing Activity

Calprotectin (S100A8/S100A9), an Inflammatory Protein Complex from Neutrophils with a Broad Apoptosis-Inducing Activity

Diagnostic Value of Fecal Calprotectin as a Screening Biomarker for Gastrointestinal Malignancies

Correlation of Two Capsule Endoscopy Scoring Systems with Fecal Calprotectin: Does It Really Matter?

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