Failure Modes of Implanted Neural Interfaces

Delbeke, Jean; Haesler, Sebastian; Prodanov, Dimiter

doi:10.1007/978-3-030-41854-0_6

Cited by 12 publications

(16 citation statements)

References 187 publications

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“…However, this sample only represents those manufacturers who have reported device failures and, unsurprisingly, most reported failures included minimal information about the cause. The results in Table 4 are similar to those found in searches which considered a broader range of clinical applications [22,140]. Increased fibrous tissue and macrophage response [118].…”

Section: Failure Modessupporting

confidence: 79%

“…To complicate matters further, electrodes need to be thin enough to remain flexible while maintaining mechanical stability upon implantation. As a result, the electrode design is crucial, providing the physical interface between the biological neural tissue and the implanted electronics [22]; this has led to a plethora of new materials being developed for electrode fabrication [23,24].…”

Section: Introductionmentioning

confidence: 99%

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Achieving long-term stability of thin-film electrodes for neurostimulation

Oldroyd

Malliaras

2022

Acta Biomaterialia

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Section: Failure Modessupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Achieving long-term stability of thin-film electrodes for neurostimulation

Oldroyd

Malliaras

2022

Acta Biomaterialia

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“…Mechanical mismatch between the implant (Young's modulus 50-200 GPa) and the soft tissue (Young's modulus 0.2-15 kPa) may evoke an immune response, tissue scarring or trauma induced by implant placement or micromotion of the implant, and may explain electrode degradation and reduced stimulation efficacy over time (78)(79)(80)(81)(82). Moreover, poor implant-tissue adhesion, vascular damage, inflammation, electrode failure, and foreign body response can be linked with device rigidity and may lead to acute and chronic responses and electrode failure (83)(84)(85)(86).…”

Section: Flexibility and Substrate Stiffnessmentioning

confidence: 99%

Soft Devices for High-Resolution Neuro-Stimulation: The Interplay Between Low-Rigidity and Resolution

Vėbraitė

Hanein

2021

Front. Med. Technol.

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The field of neurostimulation has evolved over the last few decades from a crude, low-resolution approach to a highly sophisticated methodology entailing the use of state-of-the-art technologies. Neurostimulation has been tested for a growing number of neurological applications, demonstrating great promise and attracting growing attention in both academia and industry. Despite tremendous progress, long-term stability of the implants, their large dimensions, their rigidity and the methods of their introduction and anchoring to sensitive neural tissue remain challenging. The purpose of this review is to provide a concise introduction to the field of high-resolution neurostimulation from a technological perspective and to focus on opportunities stemming from developments in materials sciences and engineering to reduce device rigidity while optimizing electrode small dimensions. We discuss how these factors may contribute to smaller, lighter, softer and higher electrode density devices.

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“…additionally criticized the lack of reported failures in current publications as they correctly deemed it vital for preventing repetition of the same mistakes in the future. [ 169 ]…”

Section: Tools To Enhance Long‐term Stability and Biocompatibility Ofmentioning

confidence: 99%

“…[131] Delbeke et al additionally criticized the lack of reported failures in current publications as they correctly deemed it vital for preventing repetition of the same mistakes in the future. [169] In proof-of-concept studies several exciting new approaches were tested to address the aforementioned issues: 1) Tissue disruption and encapsulation could be minimized by using biohybrid devices in which cultured neurons or muscle cells are used as an intermediary between the target tissue and the electronic device ( Figure 9D,iii). Several biohybrid approaches have been tested already in vivo in which cultured muscle cells [134] or neurons [170,171] are used as a relay to connect to the nervous system.…”

Section: Tools To Enhance Long-term Stability and Biocompatibility Ofmentioning

confidence: 99%

Soft Electronics Based on Stretchable and Conductive Nanocomposites for Biomedical Applications

Zambrano

Renz

Ruff

et al. 2020

Adv Healthcare Materials

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Research on the field of implantable electronic devices that can be directly applied in the body with various functionalities is increasingly intensifying due to its great potential for various therapeutic applications. While conventional implantable electronics generally include rigid and hard conductive materials, their surrounding biological objects are soft and dynamic. The mechanical mismatch between implanted devices and biological environments induces damages in the body especially for long‐term applications. Stretchable electronics with outstanding mechanical compliance with biological objects effectively improve such limitations of existing rigid implantable electronics. In this article, the recent progress of implantable soft electronics based on various conductive nanocomposites is systematically described. In particular, representative fabrication approaches of conductive and stretchable nanocomposites for implantable soft electronics and various in vivo applications of implantable soft electronics are focused on. To conclude, challenges and perspectives of current implantable soft electronics that should be considered for further advances are discussed.

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Failure Modes of Implanted Neural Interfaces

Cited by 12 publications

References 187 publications

Achieving long-term stability of thin-film electrodes for neurostimulation

Achieving long-term stability of thin-film electrodes for neurostimulation

Soft Devices for High-Resolution Neuro-Stimulation: The Interplay Between Low-Rigidity and Resolution

Soft Electronics Based on Stretchable and Conductive Nanocomposites for Biomedical Applications

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