Faktor Risiko Hiperkoagulasi pada Thalassemia Anak

Tejasari, Ridha Kurnia; Reniarti, Lelani; Effendi, Sjarif Hidajat

doi:10.14238/sp16.6.2015.427-33

Cited by 4 publications

(6 citation statements)

References 18 publications

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“…Rosendaal [16] stated that age increases the risk of thrombosis also in other study that had already stated that thrombosis may occur at the early age [17]. On the other hand, Tejasari et al [9] mentioned that age was not a factor that is associated with a hypercoagulable state. Repeated blood transfusions especially in major beta-thalassemia with increasing the intestinal absorption of iron will cause excess iron accumulation in various tissues of the body.…”

Section: Discussionmentioning

confidence: 94%

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Correlation between Serum Malondialdehyde and sVCAM-1 in Pediatric Thalassemic Patients with Hypercoagulation

Hartadi¹,

Reniarti²,

Nataprawira³

2017

OJPed

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Introduction: Repeated blood transfusions with increased intestinal iron absorption in thalassemia causes iron overload, catalyzed production of various reactive oxygen species subsequently trigger oxidative stress. Endothelial as the first organ exposed to reactive oxygen species would suffer a marked increase in adhesion molecule due to endothelial dysfunction that will trigger a hypercoagulation. Objective: To investigate the correlation between oxidative stress status (malondialdehyde, MDA) and endothelial dysfunction (serum Vascular Cell Adhesion Molecule-1, sVCAM) in iron overload pediatric thalassemic patients with hypercoagulation. Methods: A cross-sectional study was conducted on thalassemic subjects with inclusion criteria: aged 5 -14 years with iron overload who had hypercoagulation based on TEG (Thromboelastography) examination. The determination of thalassemia degree was based on a Novel scoring system. The correlation between serum MDA and sVCAM-1 was analyzed using Rank Spearman, with a significance value of 5% and 95% confidence intervals. Results: Nineteen male and twelve female children were included in the study. All subjects had pretransfusion Hb < 9 g/dL and the nutritional status of moderate malnutrition. The results showed a moderately positive significant correlation between serum MDA and sVCAM-1 levels (p = 0.02, r = 0.416). The results also showed that there was a significant difference between serum MDA and thalassemia degree (p = 0.029, <0.05), whereas levels of serum MDA in severe degree of thalassemic group were higher than in moderate degree group based on analysis using unpaired t-test (p = 0.026). Conclusions: Serum MDA level as stress oxidative status marker has moderately positive correlation with sVCAM-1 as endothelial dysfunction marker in iron overloaded pediatric thalassemic patients with hypercoagulation.

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Section: Discussionmentioning

confidence: 94%

“…Hasan Sadikin Hospital found 70% of children who experienced a hypercoagulable state had no obvious symptoms and might also occur before clinical manifestations arise [9]. This raised awareness of the presence of chronic hypercoagulable state in pediatric patients with thalassemia.…”

Section: Introductionmentioning

confidence: 99%

Correlation between Serum Malondialdehyde and sVCAM-1 in Pediatric Thalassemic Patients with Hypercoagulation

Hartadi¹,

Reniarti²,

Nataprawira³

2017

OJPed

Self Cite

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“…Thalassemia major patients experience immune mechanisms in the form of neutropenia, thrombocytosis, and lymphocytosis 5,26,27 . While chronic hypercoagulability is widely observed in thalassemia patients, it is mainly reported in adult subjects.…”

Section: Association Between Sii Value and Sgot Levelmentioning

confidence: 99%

Association Between Immune-Inflammation Index (SII) and Ferritin with Hepatic Function in Patients with Thalassemia Major

Safitri,

Setiawan L,

Arkhaesi

et al. 2024

dmj

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Background: Thalassemia major is associated with ferritin levels and SII values with impaired liver function. Furthermore, the measurement of impaired liver function is carried out using Serum Glutamate Oxaloacetate Transaminase (SGOT) and Serum Glutamate Pyruvate Transaminase (SGPT) levels. Increased SGPT and SGOT levels are indicators of liver necrosis. Objective: This study aimed to prove the association between SII and ferritin with SGPT and SGOT levels in thalassemia major patients. Methods: An observational analysis with a cross-sectional approach was adopted to analyze the medical records of pediatric patients at the Kasuari Clinic of Dr. Kariadi Hospital Semarang from September to October 2023. SII value and ferritin level were the independent variables, while SGOT and SGPT were dependent. Data were collected and analyzed univariately for characteristic description and bivariately using the Spearman test. Results: The results showed that there was a moderately significant association between SII values and SGOT levels (p=0.010, r=-0.457) as well as ferritin and SGPT (p=007, r=0.475). There was no significant association between SII values and SGPT levels, as shown by a P-value of 0.122. Similarly, there was no association between ferritin and SGOT levels (p=0.088). Conclusion: A moderately significant association was found between SII values and SGOT levels, as well as ferritin levels and SGPT levels in thalassemia major patients. In the case of SII values and SGPT levels, as well as ferritin and SGOT, there was no significant association.

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“…Indonesian Dietary fiber content was analyzed using enzymatic gravimetry method [14]. A quantity of 1 g suwar-suwir caisim was added to 20 ml of distilled water and set the pH to 1.5, then add 100 mg pepsin and incubated and agitated for 60 min at 40 o C. After that, add 20 ml of distilled water and set the pH 6.8, then add 100 mg of pancreatin and incubate at 40 o C for 60 min Set the pH 4.5 and filtered with coarse filter paper of certain weight, then washed with distilled water 2x20 ml.…”

Section: Carbohydrate Contentmentioning

confidence: 99%

Evaluation of Physical Characteristics, Carbohydrate Content, and Sensory Preference of Suwar-suwir Caisim

Tejasari,

Safitri

2023

IFSTJ

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Suwar-suwir is Jember-Indonesia’s traditional snack made from cassava fermented (tape) and sugar which give rises to very sweet flavor and sticky texture, causing consumer disfavor. This study aimed to determine the amount of mustard caisim powder added for fixing suwar-suwir texture, color and its sensory preference. This complete randomized controlled design tested effects of 6 level mustard caisim powder addition (Control=K=0, SF1=17, SF2=25, SF3=33, SF4=42, SF5=50%) toward suwar-suwir quality and sensory preference. The result showed that the addition significantly (P<0.05) affected physical properties and carbohydrate level (Fc>Ftab), and sensory liking preference (X2c >X2tab). The higher the addition of mustard caisim powder, the lower the texture value, the lower the color, the higher carbohydrate content. Suwar-suwir produced with 17% mustard caisim powder (SF1) has the best color, flavor, and overall performance. This suwar-suwir SF1 having more crunchy dense (163.2±4.80 mm/g.s,) more light green (29.59±0.29), high carbohydrate level (81.59±0.96%), high dietary fiber-TDF (20.8±0.01%), water soluble dietary fiber- SDF (6.29±0.002%) that lower than water insoluble dietary fiber - IDF (14.2± 0.01%). Based on the result analysis, it is recommend that the level addition of mustard caisim powder for improving suwar-suwir quality and image is 17 % from wet blend dough weight which produced suwar-suwir caisim SF1.

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Faktor Risiko Hiperkoagulasi pada Thalassemia Anak

Cited by 4 publications

References 18 publications

Correlation between Serum Malondialdehyde and sVCAM-1 in Pediatric Thalassemic Patients with Hypercoagulation

Correlation between Serum Malondialdehyde and sVCAM-1 in Pediatric Thalassemic Patients with Hypercoagulation

Association Between Immune-Inflammation Index (SII) and Ferritin with Hepatic Function in Patients with Thalassemia Major

Evaluation of Physical Characteristics, Carbohydrate Content, and Sensory Preference of Suwar-suwir Caisim

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