False-positive pneumococcal antigen test in meningitis diagnosis

Alonso-Tarrées, Carles; Cortés-Lletget, Cristina; Casanova, Teresa Valdaliso; Doménech, Ana

doi:10.1016/s0140-6736(01)06368-1

Cited by 14 publications

(6 citation statements)

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“…Also, pneumococcal antigen was detected for 30 days following initial subculture for all bottles. False-positive reactions may occur, and several authors have demonstrated that viridans group streptococci, in particular the Streptococcus mitis group, may cross-react with the pneumococcal C polysaccharide antigen (1,4,8,11). All three false-positive results in our study were due to organisms within the S. mitis group.…”

mentioning

confidence: 45%

Streptococcus pneumoniae Antigen Test Using Positive Blood Culture Bottles as an Alternative Method To Diagnose Pneumococcal Bacteremia

2005

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Recovery of Streptococcus pneumoniae from positive blood culture bottles may be difficult due to autolysis of pneumococci. Therefore, we evaluated the performance of the Binax NOW S. pneumoniae antigen test with samples from positive blood culture bottles and defined the duration of detectable pneumococcal antigen in these bottles. Use of the S. pneumoniae antigen test is an alternative method for identifying S. pneumoniae from positive blood culture bottles and may enable a diagnosis of pneumococcal bacteremia despite negative subcultures.

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mentioning

confidence: 45%

Streptococcus pneumoniae Antigen Test Using Positive Blood Culture Bottles as an Alternative Method To Diagnose Pneumococcal Bacteremia

2005

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“…mitis [1]. We speculate that the growth of S. sanguis and S. mitis in pleural fluid produces the same cross-reaction, thus explaining these two false positives.…”

Section: Discussionmentioning

confidence: 80%

Usefulness of pneumococcal antigen detection in pleural effusion for the rapid diagnosis of infection by Streptococcus pneumoniae

et al. 2009

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Pleural effusion is increasingly reported in children. Standard culture of blood or pleural fluid is frequently negative and molecular diagnosis by polymerase chain reaction is not available in all hospitals. The Binax NOW Streptococcus pneumoniae Antigen test (Binax, Portland, USA) is a rapid immunochromatographic test (ICT) for the detection of the C polysaccharide antigen. We evaluated the Binax NOW test on the pleural fluid of 73 children hospitalized with pleural effusion over a period of 4 years. In our sample, the sensitivity and specificity of ICT were high (88% and 71%, respectively), with a positive predictive value of 96%. Detection of the pneumococcal antigen in pleural fluid by ICT is easy and quick, and enables us to identify the pneumococcal origin of the effusion, thus, making the treatment of complicated pneumonia suitably and early.

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“…CSF immunochromatography was superior to CSF culture and latex agglutination testing in this study, but a comparison to CSF Gram staining was not done [78]. Falsepositive results have been reported in patients with meningitis due to other streptococcal species [79]. Further studies in patients with negative CSF culture and Gram stain should be performed to determine whether this method has any value in addition to standard diagnostic methods.…”

Section: Diagnostic Accuracy Of Laboratory Techniques In Bacterial Mementioning

confidence: 74%

ESCMID guideline: diagnosis and treatment of acute bacterial meningitis

Beek

Cabellos

Džupová

et al. 2016

Clinical Microbiology and Infection

646

504

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False-positive pneumococcal antigen test in meningitis diagnosis

Cited by 14 publications

References 1 publication

Streptococcus pneumoniae Antigen Test Using Positive Blood Culture Bottles as an Alternative Method To Diagnose Pneumococcal Bacteremia

Streptococcus pneumoniae Antigen Test Using Positive Blood Culture Bottles as an Alternative Method To Diagnose Pneumococcal Bacteremia

Usefulness of pneumococcal antigen detection in pleural effusion for the rapid diagnosis of infection by Streptococcus pneumoniae

ESCMID guideline: diagnosis and treatment of acute bacterial meningitis

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