Familial Aggregation of Leishmania chagasi Infection in Northeastern Brazil

Cabello, Pedro Hernán; Lima, Angela Maria V. M. Dias; Azevêdo, Eliane S.; Krieger, Henrique

doi:10.4269/ajtmh.1995.52.364

Cited by 49 publications

(36 citation statements)

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“…No entanto, Sabroza et al (1992), Evans et al (1992), Dietze et al (1997) e Paula (2005 não verificaram essa associação, sendo a eutanásia de cães soropositivos questionável para estes autores. Cabello et al (1995) acreditam que a transmissão da LV entre humanos deve ser mais bem investigada para se mensurar o potencial real do cão como reservatório da doença.…”

Section: Methodsunclassified

Presença de animais associada ao risco de transmissão da leishmaniose visceral em humanos em Belo Horizonte, Minas Gerais

Borges¹,

Silva²,

Haddad³

et al. 2009

Arq. Bras. Med. Vet. Zootec.

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RESUMOAnalisou-se o risco de se contrair leishmaniose visceral (LV) e a presença de animais em residências de Belo Horizonte/MG, em 2006. O estudo de caso-controle foi feito por meio de visitas domiciliares, aplicação de questionário e registro de imagens da residência. A estimativa de risco foi mensurada por comparação de condições de moradia entre dois grupos: 1-constituído por 82 casos humanos de LV ocorridos em 2004 e 2-164 controles (vizinhos dos casos). Os domicílios pertencentes ao grupo 1 foram os que apresentaram os maiores percentuais de presença de animais. Observou-se, pela análise univariada, que a presença de patos, roedores, pássaros e galinhas aumenta o risco de ocorrer LV em 4,18; 1,81; 1,57; e 1,47 vezes, respectivamente. Para os proprietários de cães, o aumento no risco de contrair LV é equivalente a 2,17 vezes e está relacionado ao número de cães no domicílio. O risco de contrair LV é maior 1,87 vezes para moradores com um cão e 3,36 vezes para moradores com dois cães, quando comparados a pessoas que não possuem esses animais. ; birds with an OR of Palavras-chave: leishmaniose visceral, fator de risco ABSTRACT This study evaluated the animal presence in dwellings and the risk for transmission of visceral leishmaniasis (VL) in Belo Horizonte, Brazil, 2006. A case-control study was conducted by means of dwelling visits, direct interviews, and image register in the houses. The risk estimates were produced comparing the dwelling condition between two groups: 1) 82 human cases of VL recorded in 2004; and 2) 164 controls (neighbors of the first). The cases presented a higher proportion in the animal presence compared to controls. Using an unconditional logistic regression, it was selected the presence of ducks

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Section: Methodsunclassified

Presença de animais associada ao risco de transmissão da leishmaniose visceral em humanos em Belo Horizonte, Minas Gerais

Borges¹,

Silva²,

Haddad³

et al. 2009

Arq. Bras. Med. Vet. Zootec.

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“…Alternatively a great number of cases of VL in one family may be related to increased exposure since L. chagasi transmission is predominantly peridomiciliar. It was demonstrated an intrafamilial pattern of infection in VL in an endemic area (Jacobina, BA, Brazil) with a strong suggestion of at least partial genetic involvement (Cabello et al 1995).…”

mentioning

confidence: 99%

Asymptomatic Leishmania chagasi Infection in Relatives and Neighbors of Patients with Visceral Leishmaniasis

Júnior¹,

Costa²,

Barbosa³

et al. 1997

Mem. Inst. Oswaldo Cruz

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“…One hundred replicates were generated using parameters (single gene additive model; allele frequency for disease gene q = 0.0016; extremes of age-related penetrances of 7% and 61%) defined initially by segregation analysis performed for these families, 4 Table 5. These critical values are equivalent to allele-sharing LOD scores of 0.59, 1.17, 2.07, 3.00 and 3.95.…”

Section: Power To Detect Linkagementioning

confidence: 99%

“…47 One hundred replicates were generated using parameters (single gene additive model; allele frequency for disease gene q = 0.0016; extremes of age-related penetrances of 7% and 61%) defined initially by segregation analysis performed for these families, 4 and actual HLA marker information for all individuals in the pedigrees. The simulated data sets were then used to carry out nonparametric linkage analysis within ALLEGRO to determine power to detect linkage at critical values of NPL all scores.…”

Section: Linkage Simulationsmentioning

confidence: 99%

“…Evidence from specific skintest reactivity and lymphocyte proliferation assays [1][2][3] indicates that only a small subset of people infected with leishmanial parasites develop clinical disease. Familial aggregation is a feature of visceral leishmaniasis caused by L. chagasi in northeastern Brazil, 4 providing a high relative risk ( 2S = 34) of disease in further siblings of affected sibling pairs. 5 Segregation analysis supports single dominant or additive gene control, with a frequency of ෂ0.002 for the disease allele and penetrances ranging from 7% (Ͻ1 year olds) to 61% (9-10 year olds) according to age liability classes.…”

Section: Introductionmentioning

confidence: 99%

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Genetic analysis of multicase families of visceral leishmaniasis in northeastern Brazil: no major role for class II or class III regions of HLA

et al. 2002

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Familial Aggregation of Leishmania chagasi Infection in Northeastern Brazil

Cited by 49 publications

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Presença de animais associada ao risco de transmissão da leishmaniose visceral em humanos em Belo Horizonte, Minas Gerais

Presença de animais associada ao risco de transmissão da leishmaniose visceral em humanos em Belo Horizonte, Minas Gerais

Asymptomatic Leishmania chagasi Infection in Relatives and Neighbors of Patients with Visceral Leishmaniasis

Genetic analysis of multicase families of visceral leishmaniasis in northeastern Brazil: no major role for class II or class III regions of HLA

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