Familial clustering of malignant astrocytomas

Lossignol, Dominique; Grossman, Stuart A.; Sheidler, Vivian R.; Griffin, Constance A.; Piantadosi, Steven

doi:10.1007/bf02427834

Cited by 20 publications

(4 citation statements)

References 27 publications

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“…25 Studies of patients with glioma and segregation of cancer in their first-and second-degree relatives have supported multigenic Mendelian inheritance as well as environmental influences 26 ; even patterns suggestive of autosomal recessive inheritance have been noted. 2 Following several case reports suggesting familiality in astrocytoma, [27][28][29] the National Brain Tumor Registry was established to study the familiality in tumors involving first-degree relatives and spouses. Results of the study of 72 families demonstrated no significantly lower age at onset; clustering in time; and a significant number of occurrences in spouses.…”

Section: Results Relative Risksmentioning

confidence: 99%

Familiality in brain tumors

Blumenthal¹,

Cannon‐Albright²

2008

Neurology

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Section: Results Relative Risksmentioning

confidence: 99%

Familiality in brain tumors

Blumenthal¹,

Cannon‐Albright²

2008

Neurology

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“…Perhaps the single most compelling report of this nature is one by Maroun et al 6 describing two interrelated Newfoundland families with ten affected persons in three generations. Recently, Lossignol et al 3 have observed that 9.4% (3/32) of patients with anaplastic astrocytomas enrolled in a treatment protocol at The Johns Hopkins Oncology Center had at least one first degree relative with an astrocytic tumor. They speculated that gliomas might occur in families more frequently than previously recognized.…”

Section: Discussionmentioning

confidence: 99%

Gliomas in Families

Ikizler

Meyel²,

Ramsay³

et al. 1992

Can. j. neurol. sci.

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ABSTRACT:This is a descriptive study of 19 families with glial tumors. Twelve were identified prospectively from 178 consecutive, unrelated adults and children with newly diagnosed gliomas seen at a regional cancer center between 01 Jan 89 and 31 Mar 91 (6.7%). There were 45 affected members (42 confirmed); 30 males, 15 females, ages 4 months-78 years (median, 44.5 years; mean, 38.9 years). Two families had four affected members, three families had three, and the others two. All confirmed tumors were supratentorial and all, save one, contained an astrocytic element. Three additional members of two families had other brain or neuroectodermal tumors. These families were not unusually cancer prone and did not appear to have neurofibromatosis, tuberous sclerosis, or colonic polyposis. There was no consistent pattern of inheritance.

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“…High‐grade gliomas are aggressive primary brain tumors with few known etiologic risk factors. Familial brain tumor syndromes and genetic disorders account for approximately 1–10% of all gliomas 1, 2. To our knowledge, ionizing radiation is the only known environmental risk factor for the development of high‐grade gliomas,3 but is reported to be a contributing etiologic factor in < 1% of patients.…”

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confidence: 99%

High‐grade gliomas in patients with prior systemic malignancies

Maluf

DeAngelis

Raizer

et al. 2002

Cancer

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BACKGROUND The current study was conducted to characterize the impact of a prior malignancy on the diagnosis, treatment, and outcome of high‐grade glioma. METHODS A retrospective study of 21 patients with a histologic diagnosis of glioblastoma multiforme (GBM), anaplastic astrocytoma (AA), or anaplastic oligodendroglioma (AO) after a prior diagnosis of solid tumor or hematologic malignancy was conducted. Glioma histology (GBM vs. AA/AO), patient age (≤ 60 years vs. > 60 years), and extent of resection (biopsy vs. subtotal vs. complete) were evaluated for their prognostic influence. RESULTS Of the 21 patients studied, 17 had GBM, 3 had AA, and 1 patient had high‐grade AO. There were 25 systemic carcinomas diagnosed in 21 patients (18 solid tumors including breast carcinoma, prostate carcinoma, and melanoma and 7 hematologic malignancies). The glioma occurred within a previous radiation field in only three patients, two of whom had solid tumors and one of whom had a childhood hematologic malignancy. Surgical resection was the initial treatment for the brain tumor in 17 patients, and the majority of patients received radiation therapy and adjuvant chemotherapy. Four patients who initially were misdiagnosed as having brain metastases received whole brain radiation therapy as their initial treatment, thereby compromising optimal care. The overall median survival for all the patients in the current study was 14 months (range, 1–44 months) from the time of brain tumor diagnosis. The extent of resection was found to be the only prognostic variable that was associated with survival (P = 0.03). CONCLUSIONS Secondary glioma may occur in patients as a consequence of therapy for a prior malignancy, but most often represents a sporadic event. The outcome and recommended treatment are identical to those for patients with primary gliomas. Accurate diagnosis is essential; neuroimaging often is suggestive of a primary brain tumor and should initiate surgical intervention so that histopathology can be obtained early and appropriate treatment instituted. Cancer 2002;94:3219–24. © 2002 American Cancer Society. DOI 10.1002/cncr.10595

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Familial clustering of malignant astrocytomas

Cited by 20 publications

References 27 publications

Familiality in brain tumors

Familiality in brain tumors

Gliomas in Families

High‐grade gliomas in patients with prior systemic malignancies

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