Familiality in brain tumors

Blumenthal, Deborah T.; Cannon‐Albright, Lisa A.

doi:10.1212/01.wnl.0000326597.60605.27

Cited by 51 publications

(42 citation statements)

References 33 publications

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“…2,29,30 The RR is defined as the ratio of the observed number of cases among the relatives of probands to the expected number based on the population rate of disease.…”

Section: Discussionmentioning

confidence: 99%

“…These combined resources have been extensively used to identify familial clustering of cancer and other diseases. 16,17,[22][23][24][25][26][27][28][29][30] The Utah population contained in the UPDB is genetically representative of Northern Europe and has similar inbreeding levels as compared with other parts of the United States. 31,32 the UcR…”

Section: Materials and Methods The Utah Population Data Basementioning

confidence: 99%

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A comprehensive survey of cancer risks in extended families

Teerlink

Albright

Lins

et al. 2012

Genetics in Medicine

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original research article Purpose: Cancer is familial; yet known cancer predisposition genes, as well as recognized environmental factors, explain only a small percentage of familial cancer clusters. This population-based description of cancer clustering describes patterns of cancer coaggregation suggestive of a genetic predisposition. methods: Using a computerized genealogy of Utah families linked to a statewide cancer registry, we estimated the relative risks for 36 different cancer sites in first-, second-, and third-degree relatives of cancer cases, for each cancer site individually, and between cancer sites. We estimated the sex-and birth-year-specific rates for cancer using 1 million individuals in the resource. We applied these rates to groups of cases or relatives and compared the observed and expected numbers of cancers to estimate relative risks.Results: Many cancer sites show significantly elevated relative risks among distant relatives for cancer of the same site, strongly supporting a heritable contribution. Multiple combinations of cancer sites were observed among first-, second-, and third-degree relatives, suggesting the existence of heritable syndromes involving more than one cancer site.conclusion: This complete description of coaggregation of cancer by site in a well-defined population provides a set of observations supporting heritable cancer predispositions and may support the existence of genetic factors for many different cancers.Genet Med 2012:14(1):107-114

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“…2,29,30 The RR is defined as the ratio of the observed number of cases among the relatives of probands to the expected number based on the population rate of disease.…”

Section: Discussionmentioning

confidence: 99%

Section: Materials and Methods The Utah Population Data Basementioning

confidence: 99%

A comprehensive survey of cancer risks in extended families

Teerlink

Albright

Lins

et al. 2012

Genetics in Medicine

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“…DMN-CEN connectivity at the left DLPFC was also a mediator of family history and impulsivity (coefficient = 0.9, P = 0.05). (Blumenthal and Cannon-Albright, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…Age, sex, generation, familial relatedness based on a kinship coefficient (Blumenthal and Cannon-Albright, 2008), prior medication exposure, and history of depression, anxiety, or substance use disorder were included as covariates. Regions with positive functional connectivity with the DMN component were indexed within DMN connectivity; conversely, we examined connection strength between the DMN component and the CEN based on predefined masks (Seeley et al, 2007).…”

Section: Hypothesis Testingmentioning

confidence: 99%

Increased Default Mode Network Connectivity in Individuals at High Familial Risk for Depression

Posner

Cha

Wang

et al. 2015

Neuropsychopharmacol

117

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Research into the pathophysiology of major depressive disorder (MDD) has focused largely on individuals already affected by MDD. Studies have thus been limited in their ability to disentangle effects that arise as a result of MDD from precursors of the disorder. By studying individuals at high familial risk for MDD, we aimed to identify potential biomarkers indexing risk for developing MDD, a critical step toward advancing prevention and early intervention. Using resting-state functional connectivity MRI (rs-fcMRI) and diffusion MRI (tractography), we examined connectivity within the default mode network (DMN) and between the DMN and the central executive network (CEN) in 111 individuals, aged 11-60 years, at high and low familial risk for depression. Study participants were part of a threegeneration longitudinal, cohort study of familial depression. Based on rs-fcMRI, individuals at high vs low familial risk for depression showed increased DMN connectivity, as well as decreased DMN-CEN-negative connectivity. These findings remained significant after excluding individuals with a current or lifetime history of depression. Diffusion MRI measures based on tractography supported the findings of decreased DMN-CEN-negative connectivity. Path analyses indicated that decreased DMN-CEN-negative connectivity mediated a relationship between familial risk and a neuropsychological measure of impulsivity. Our findings suggest that DMN and DMN-CEN connectivity differ in those at high vs low risk for depression and thus suggest potential biomarkers for identifying individuals at risk for developing MDD.

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“…Meningiomas are reported in families of several cancer predisposition syndromes including those involving the genes NF1, PTCH, CREBBP, VHL, PTEN, and CDKN2A (Simon et al, 2007). Another study conducted in Israel (Blumenthal, 2008) found a strong evidence for a familial contribution to primary brain cancer risk. There is evidence that this familial aspect includes not only shared environment, but also a heritable component.…”

Section: High Incidence Of Benign Brain Meningiomas Among Iranianbornmentioning

confidence: 99%

High Incidence of Benign Brain Meningiomas among Iranian-born Jews in Israel may be Linked to both Hereditary and Environmental Factors

Barchana

Liphshitz²

2013

Asian Pacific Journal of Cancer Prevention

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Patients that were born in Iran, Iraq, Turkey, Bulgaria and Greece were used for the analysis, whereby we calculated adjusted incidence rates per 100,000 people and computed standardized incidence ratios (SIRs) comparing the Iranian-born to each of the three other groups. Results: Iranian-born Jews had statistically significant higher meningioma rates rates compared to other Jews originating in Balkan states: 1.46 fold compared to Turkish Jews and 1.86 fold compared to the Bulgaria-Greece group. There was a small increase in risk for the Iranian born group compared to those who were born in Iraq (1.06, not significant). Conclusions: Higher rates of meningiomas were seen in Jews originating in Iran that are living in Israel as compared to rates in neighboring countries of origin. These differences can be in part attributed to early life environmental exposures in Iran but probably in larger amount are due to genetic and hereditary factors in a closed community like the Iranian Jews. Some support for this conclusion was also found in other published research.

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Familiality in brain tumors

Abstract: Background: Familiality in brain tumors is not definitively substantiated.

Cited by 51 publications

References 33 publications

A comprehensive survey of cancer risks in extended families

A comprehensive survey of cancer risks in extended families

Increased Default Mode Network Connectivity in Individuals at High Familial Risk for Depression

High Incidence of Benign Brain Meningiomas among Iranian-born Jews in Israel may be Linked to both Hereditary and Environmental Factors

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