Familial stomatocytosis — hypertrophic gastritis (FSHG), a newly recognised disease in the dog (Drentse patrijshond)

Slappendel, R.J.; Gaag, I van der; Nes, J.J. van; Ingh, T S van den; Happé, R.P.

doi:10.1080/01652176.1991.9694282

Cited by 29 publications

(20 citation statements)

References 13 publications

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“…12 The disease has also been reported in Drentse Patrijshonds as a component of the familial stomatocytosis-hypertrophic gastritis syndrome. 10 People with Ménétrier disease can develop hypoproteinemia and anemia due to protein and blood leakage through the altered gastric mucosa. 1,8 Neither hypoproteinemia nor anemia developed in the Cairn terriers.…”

Section: Discussionmentioning

confidence: 99%

Ménétrier Disease and Gastric Adenocarcinoma in 3 Cairn Terrier Littermates

Munday

Cullen

French³

2012

Vet Pathol

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Ménétrier disease is a rare hypertrophic gastropathy that is characterized by hyperplasia of the mucous cells with concurrent loss of chief and parietal cells within the gastric glands. There are few reports of this disease in dogs, and little is known about the clinical presentation and progression of canine Ménétrier disease. Three Cairn terrier littermates developed hypertrophic gastropathy with histological features of Ménétrier disease. One dog remained clinically asymptomatic for 2 years after diagnosis. The development of this disease in 3 siblings suggests a possible inherited predisposition. All 3 dogs also developed gastric neoplasia, which has been reported in human Ménétrier disease but has not been associated previously with hypertrophic gastropathy in domestic species.

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Section: Discussionmentioning

confidence: 99%

Ménétrier Disease and Gastric Adenocarcinoma in 3 Cairn Terrier Littermates

Munday

Cullen

French³

2012

Vet Pathol

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“…Familial stomatocytosis-hypertrophic gastritis, has also been identified in a group of closely related Drents (Slappendel and others 1991). In addition, several disorders that likely have a genetic component are found in Drents including hip dysplasia, hypothyroidism, absent teeth and cryptorchidism (O'Connor 2014).…”

Section: Discussionmentioning

confidence: 99%

Genetic screening and mutation identification in a rare canine breed, the Drentsche patrijshond

Shaffer

Ramirez²,

Sundin³

et al. 2015

Vet Record Case Reports

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The Drentsche patrijshond (Drent) is a relatively rare breed that is used as a versatile hunting dog. Although inherited diseases occur in this breed, no genetic mutations were previously known to contribute to these inherited disorders. Thirteen Drents were screened for 142 known disease-associated mutations that occur in domestic dogs. Of these, two mutations were identified to segregate in three pedigrees: mutations for hyperuricosuria and von Willebrand disease type 1. This information can be used to screen Drents before breeding to improve the health of the breed and to avoid producing affected dogs and emphasises the importance of genetic screening for inherited diseases in rare breeds.

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“…The diagnosis FS-HG and the blood phospholipid analysis of these dogs were established while the animals were still alive. Apart from giant hypertrophic gastritis of the corporal region of the stomach, signs of FS-HG in dogs included abnormal erythrocyte shape (stomatocytosis), increased osmotic fragility, a decreased cholesterol content of the red cell membrane, increased plasma cholesterol, a decreased phosphatidylcholine and an increased sphingomyelin content in both plasma and erythrocytes, hyperbilirubinaemia and high levels of liver enzymes [18,19]. At necropsy, histology of the liver showed bile duct proliferation in portal areas.…”

Section: Methodsmentioning

confidence: 99%

“…In dogs, hypertrophic gastritis, resembling Ménétrier's disease in man, has been demonstrated as part of a hereditary syndrome named familial stomatocytosishypertrophic gastritis (FS-HG) [18]. In addition to giant hypertrophic gastritis, affected dogs consistently exhibit abnormal phospholipid composition of the erythrocyte membrane and plasma, progressive liver disease, neurological disturbances and, in some cases, polycystic renal disease [18,19]. The combination of these symptoms might suggest a generalized defect in lipid metabolism and has raised the question of whether the putative role of phospholipids in the pathogenesis of hypertrophic gastritis can be studied in dogs with FS-HG.…”

Section: Introductionmentioning

confidence: 99%

Gastric mucosal phospholipids in dogs with familial stomatocytosis−hypertrophic gastritis

Renooij¹,

Schmitz²,

Pg³

et al. 1996

Eur J Clin Investigation

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In dogs, hypertrophic gastritis, which resembles Ménétrier's disease in man, has been demonstrated to be part of a hereditary syndrome called familial stomatocytosis-hypertrophic gastritis. In addition to hypertrophic gastritis, affected dogs exhibit abnormal blood phospholipid composition. Phospholipids may play a role in maintaining gastric mucosal integrity, and this may be compromised in gastritis. The question arises whether the differences in blood phospholipids may result from a disorder that might also be revealed in the composition of gastric mucosal phospholipids. We analysed the phospholipid composition of gastric mucosa from four dogs with familial stomatocytosis-hypertrophic gastritis. The general phospholipid composition and the molecular composition of phosphatidylcholine from mucosal tissue in the corpus of the stomach where hypertrophic gastritis was evident were not different from that of the antrum, where the tissue was normal. These results do not corroborate a relation between the gastric mucosal phospholipid composition and hypertrophic gastritis.

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Familial stomatocytosis — hypertrophic gastritis (FSHG), a newly recognised disease in the dog (Drentse patrijshond)

Cited by 29 publications

References 13 publications

Ménétrier Disease and Gastric Adenocarcinoma in 3 Cairn Terrier Littermates

Ménétrier Disease and Gastric Adenocarcinoma in 3 Cairn Terrier Littermates

Genetic screening and mutation identification in a rare canine breed, the Drentsche patrijshond

Gastric mucosal phospholipids in dogs with familial stomatocytosis−hypertrophic gastritis

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