Family-based dispatching heuristics aim for improving job flow times by reducing time spent on set-ups. They realise set-up efficiencies by batching similar types of jobs. By their intuitiveness and the simplicity of their decision logic, they may contribute to an easy to implement and viable strategy in many practical settings. Similar to common dispatching rules most existing family-based dispatching heuristics are myopic, i.e. their decision scope is restricted to a single manufacturing stage. Hence, they neglect opportunities for improving shop performance by coordinating batching decisions with other manufacturing stages. Case examples from industry underpin the need for exploring these opportunities. We do so by studying a simple two-stage flow shop, entailing a serial and a batch stage. To facilitate shop coordination we propose extensions to existing family-based dispatching heuristics. Extended heuristics seek to further increase set-up efficiencies by allowing for upstream job re-sequencing, and pro-active set-ups, i.e. set-ups that may be initiated prior to the arrival of a job. Outcomes of an extensive simulation study indicate significant performance gains for extended heuristics vs. existing heuristics. Performance gains are largest for moderate and high set-up to run-time ratios.