Dendrimers are increasingly being studied in the context of encapsulation. Many potential applications of dendrimers are based on their properties. They are used in drug delivery systems, cosmetics, food and chemistry. This review is first devoted to different synthesis approaches for dendrimers and to their ability to encapsulate active molecules. Their applications in different fields, as well as their cytotoxicity, are then detailed. To conclude this review, the main works on the interaction of dendrimers with the stratum corneum (SC) are also presented.