Farmacologia e Toxicologia de Peumus boldus e Baccharis genistelloides

Ruiz, Ana Lúcia T. G.; Taffarello, Denise; Souza, Vanessa H. S.; Carvalho, João Ernesto de

doi:10.1590/s0102-695x2008000200025

Cited by 50 publications

(43 citation statements)

References 40 publications

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“…Boldo is popularly used in cases of hepatitis, hepatic colic, biliary lithiasis and intestinal disorders, and rheumatism, poor digestion, asthenia, dyspepsia, inappetence and other disorders 8 . Studies have demonstrated that polar extracts of Peumus boldus are able to display antioxidant activity 9 and reduce hepatic lipoperoxidation induced by cisplatin [10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

“…As boldo and its chemical compounds have previously demonstrated beneficial properties on the Peumus boldus leaves [8][9][10][11][12] , the purpose of the current study is to assess the effect of aqueous extract of the Peumus Boldus on the liver proliferative response after hepatectomy in rodents.…”

Section: Introductionmentioning

confidence: 99%

“…As in this study, leaves-derived extracts of Peumus boldus induced hepatocytes proliferation; it is possible to suggest that this natural product display trophic effects on liver tissue. The precise mechanism underlying the proliferative effect displayed by AEPB is still unclear, but it is possible to suppose a possible relation with the well-established antioxidant properties of the bioactive compounds present in the extract, such as alkaloids and flavonoids 8,9,13,29,30 . However, although we provide evidence of a possible hepatotrophic effect of AEPB, further investigations are still required in order to clarify the biochemical mechanism responsible for such biological activity.…”

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confidence: 99%

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The effect of the aqueous extract Peumus boldus on the proliferation of hepatocytes and liver function in rats submitted to expanded hepatectomy

Figueiredo

Santana²,

Nardelli

et al. 2016

Acta Cir. Bras.

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PURPOSE:To assess the effect of aqueous extract of Peumus Boldus (AEPB) on the liver proliferative response after parcial hepatectomy of 70% (PH) in rodents. METHODS:Twenty Wistar rats were divided in two groups: AEPB100 (whose rats received 100mg/Kg of AEPB, once a day, orally, in 4 days prior to the first surgical procedure) and Vehicle (whose rats were treated similarly with distilled water). Both groups underwent PH. After 24 hours the remaining livers were removed for studying the proliferation of hepatocytes by Ki-67 and 2mL of blood were collected for serological assessment: cholesterol, glucose, triglycerides, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and total, direct and indirect bilirubin. All data were analyzed by Gaussian distribution. Statistically significant differences between mean values were analyzed using T Student's test. Non-Gaussian data were analyzed using Mann-Whitney's test. RESULTS:The liver of all these rats presented positive staining of Ki-67, indicating liver proliferation. Laboratory results showed no significant difference in serum values between the analyzed groups. The analysis of Ki-67 was significantly more positive in AEPB100 group than in Vehicle group. CONCLUSION:Aqueous extract of Peumus Boldus acute administration exerts significant positive effect on liver regeneration after 24h in rats that underwent parcial hepatectomy, while maintaining unchanged hepatic function.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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The effect of the aqueous extract Peumus boldus on the proliferation of hepatocytes and liver function in rats submitted to expanded hepatectomy

Figueiredo

Santana²,

Nardelli

et al. 2016

Acta Cir. Bras.

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“…However, there are results showing that a bitter taste bolus does not alter the durations of the oral, oropharyngeal and pharyngeal phases of swallowing of normal subjects, compared with other basic tastes (10) . In this investigation, we evaluated the effect of a tea of Peumus boldus, frequently used in popular medicine (13) , which has a bitter taste, on oral, pharyngeal and esophageal transit, compared with the swallow of a sweet bolus. Our hypothesis was that the unpleasant bitter taste of this tea causes alteration of oral, pharyngeal and/or esophageal transit in normal subjects, when compared with the swallow of a sweet bolus.…”

Section: Introductionmentioning

confidence: 99%

Effect of a Bitter Bolus on Oral, Pharyngeal and Esophageal Transit of Healthy Subjects

Alves

Secaf

Dantas

2013

Arq. Gastroenterol.

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-Context -During swallowing, boluses stimulate sensory receptors of the oral, pharyngeal, laryngeal, and esophageal regions. Sweet and tasteless foods are more acceptable for swallowing than bitter foods. A bitter bolus is unpleasant for most subjects. Our hypothesis was that the ingestion of a bitter bolus might alter the oral behavior, pharyngeal and esophageal transit when compared to a sweet bolus. Objective -To evaluate whether the bitter taste of a liquid bolus causes alteration on oral, pharyngeal and/or esophageal transit in normal subjects in comparison with sweet bolus. Method -Scintigraphic evaluation of oral, pharyngeal and esophageal transit was performed in 43 asymptomatic subjects, 22 women and 21 men, ages 23-71 years, without problems with the ingestion of liquid and solid foods, and without digestive, cardiac or neurologic diseases. Each subject swallowed in random sequence and at room temperature 5 mL of a liquid bolus with bitter taste, prepared with 50 mL of water with 2 g of leaves of Peumus boldus, heated until boiling (boldus tea), and 5 mL of a liquid bolus with sweet taste, prepared with 50 mL of water with 3 g of sucrose, both labeled with 37 MBq of technetium phytate (Tc 99m ). Results -There was no difference between the bitter bolus and the sweet bolus in mouth, pharynx and esophageal transit and clearance duration and in the amount of residues. Conclusion -A bitter bolus, considered an unpleasant bolus, does not alter the duration of oral, pharyngeal and esophageal phases of swallowing, when compared with a sweet bolus, considered a pleasant bolus.

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“…Estudos fitoquímicos têm destacado a presença de uma grande variedade de constituintes químicos, justificando o uso dessas espécies na medicina popular. Peumus boldus Molina é a espécie mais conhecida, sendo mencionada em diversas farmacopéias pelo seu uso contra dispepsias, náuseas e constipação intestinal (Brandão et al, 2006;Agra et al, 2007;Ruiz et al, 2008). Nessa espécie, encontram-se alcalóides benzilisoquinolínicos como boldina, isocordina e N-metillaurotetanina (Pietta et al, 1988).…”

Section: Introductionunclassified

Anatomia e análise de óleo essencial das folhas de Hennecartia omphalandra J. Poisson (Monimiaceae)

Marques¹,

Leitão²,

Bizzo³

et al. 2009

Rev. bras. farmacogn.

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RESUMO:Descreve-se a morfo-anatomia e a análise de óleo essencial das folhas de Hennecartia omphalandra J. Poisson (Monimiaceae), uma planta tóxica. A ocorrência de tricomas unicelulares, estômatos paracíticos; braquiesclereídes em grupos no pecíolo e na lâmina foliar, além de esclereídes vermiformes e ramiformes; sistema vascular em arco, com extremidades voltadas para o centro no pecíolo e na forma de arco atenuado na lâmina foliar, sendo o padrão de venação uma variação do tipo craspedódromo-semicraspedódromo, além de óleo essencial armazenado em idioblastos oleíferos não especializados no mesofilo, foram considerados caracteres importantes que podem auxiliar na sua morfo-diagnose. A análise do óleo essencial das folhas revelou a presença de monoterpenos, sesquiterpenos e álcoois sesquiterpênicos, sendo este o grupo mais significativo. Os componentes majoritários identificados foram β-felandreno (24,0%), seguido por germacreno D (10,5%), sabineno (9,3%), biciclogermacreno (8,4%) e β-elemeno (5,3%). Unitermos:Hennecartia omphalandra, Monimiaceae, plantas tóxicas, anatomia foliar, óleo essencial.ABSTRACT: "Anatomy and essential oil analysis of the leaves from Hennecartia omphalandra J. Poisson (Monimiaceae)". This paper describes the morphological and anatomical aspects and the essential oil analysis of the leaves from Hennecartia omphalandra J. Poisson (Monimiaceae), a toxic plant. The presence of trichomes formed by a single cell, paracitic stomata, groups of braquisclereids in the petiole and leaf blade; vermiform and ramiform sclereids, vascular system in arc softly invaginated at ends in the petiole, and in a flat arc in the middle vein, being the venation pattern a variation of craspedodromous-semicraspedodromous type, and essential oil stored in oil idioblasts in the mesophyll were the most important characters that can help the morphological diagnosis. The analysis of essential oil of the leaves showed the presence of monoterpenes, as well as sesquiterpenes hydrocarbons and alcohols, being the latter the most significant group. The major identified compounds were β-phelandrene (24.0%), germacrene D (10.5%), sabinene (9.3%), bicyclogermacrene (8.4%) and β-elemene (5.3%).

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Farmacologia e Toxicologia de Peumus boldus e Baccharis genistelloides

Cited by 50 publications

References 40 publications

The effect of the aqueous extract Peumus boldus on the proliferation of hepatocytes and liver function in rats submitted to expanded hepatectomy

The effect of the aqueous extract Peumus boldus on the proliferation of hepatocytes and liver function in rats submitted to expanded hepatectomy

Effect of a Bitter Bolus on Oral, Pharyngeal and Esophageal Transit of Healthy Subjects

Anatomia e análise de óleo essencial das folhas de Hennecartia omphalandra J. Poisson (Monimiaceae)

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