Fast and Highly Efficient Solid State Oxidation of Thiols

Abstract

A fast and efficient solid state method for the chemoselective room temperature oxidative coupling of thiols to afford their corresponding disulfides using inexpensive and readily available moist sodium periodate as the reagent is described. The reaction was applicable to a variety of thiols giving high yields after short reaction times. Comparison of yield/time ratios of this method with some of those reported in the literature shows the superiority of this reagent over others under these conditions.

Disulfides – Effective radical generators for flame retardancy of polypropylene

“…were supplied by BASF, products 1, 2, 4, 6, 10, 12, 13 were purchased from Sigma Aldrich Corporation and compounds 5 [52], 7 [53], 8 [54], 9 [55] were prepared according to previously described procedures. For comparison a commercial alkoxyamine Flamestab®NOR116 (supplier BASF SE) was used.…”

Preparation and Characterization of Organically Modified MCM-48 as Heterogonous Catalyst for Oxidation of Sulfides and Thiols

“…For example in chemical processes disulfides can be used to prepare sulfinyl and sulfenyl compounds and in biological systems they control the cellular redox potential and prevent oxidative damage and formation disulfide bond is important in peptides [33][34][35][36]. Furthermore, disulfides are relatively more stable to organic reactions such as oxidation, alkylation and acylation compared to the corresponding free thiols, also the thiol group can conveniently be protected as a disulfide [37].…”

Versatile and Efficient Conversion of Thiols into Disulfides by Poly(4-vinylpyridinium tribromide) as Reusable Oxidizing Polymer

“…The chemicals and solvents were purchased from Fluka, Merck and Aldrich chemical companies without further purifications. All products are known and were characterized by comparison of their spectral (IR, 1 H NMR, or 13 C NMR) and physical data with authentic samples.…”