Fast element mapping of titanium wear around implants of different surface structures

Abstract

The effect of unintended titanium release around oral implants remains a biological concern. The current study was undertaken to evaluate a new detection system of element mapping in biological probes. A new scanning electron microscopy-energy dispersive spectroscopy detection method was used to map the features of titanium contamination in peri-implant bone around implants with different surface structures. The amount of titanium wear was highest adjacent to titanium-plasma-sprayed surfaces, followed by sandblastered large grid acid-etched and smooth surfaces. A high sensitivity of titanium detection over large areas of bone tissue was observed. A high spatial resolution of titanium wear particles (20 nm) could be reached and correlated to the ultrastructural morphological features of peri-implant tissue. Cells adjacent to titanium wear revealed no signs of morphological alterations on a nanoscale level at early periods of implant/bone interaction. The new technique may serve as a fast and effective tool to evaluate titanium release effects in biological probes.

Material attrition and bone micromorphology after conventional and ultrasonic implant site preparation

“…Biological fluids will most likely drain these elements into the serum and urine of the patients (Bertoldi et al 2005). In contrast, a previous study on dental implants found that cells in the vicinity of the Ti wear particles showed no early signs of morphological alterations (Meyer et al 2006). Galvanic corrosion of the metal deposits is likely to result in element release and the induction of inflammatory responses in peri-alloplast tissues, even in the absence of detectable metallosis (Parvizi et al 2011).…”

Macrophage polarization in aseptic bone resorption around dental implants induced by Ti particles in a murine model

“…Preclinical and clinical studies have showed that the leakage of titanium in particle or ion form into local peri‐implant tissue and distant system organs may occur during implant placement or functional loading period . Titanium particles or ions have been detected by advanced elemental analysis technologies (such as scanning electron microscopy, synchrotron radiation X‐ray fluorescence, and energy dispersive X‐ray spectrometry) in peri‐implant soft and hard tissue biopsies retrieved . Some retrospective clinical studies also implied the relationship between Ti wear debris and peri‐implant inflammatory lesions …”

Indirect casting of patient-specific tricalcium phosphate zirconia scaffolds for bone tissue regeneration using rapid prototyping methodology

“…of conined toxicity which is otherwise caused by titania implants [17,18]. Zirconia because of its approving biomechanical properties is being investigated as an alternate material for bone substitute [19].…”