Fast-Response and Reusable Oxytetracycline Colorimetric Strips Based on Nickel (II) Ions Immobilized Carboxymethylcellulose/Polyacrylonitrile Nanofibrous Membranes

Abstract

Driven by economic interests, the abuse of antibiotics has become a significant concern for humans worldwide. As one of the most commonly used antibiotics, oxytetracycline (OTC) residue in animal-derived foods occurs occasionally, which has caused danger to humanity. However, there is still no simple and efficient solution to detect OTC residue. Here, an easily-operated colorimetric strategy for OTC detection was developed based on nickel ions (Ni2+) immobilized carboxymethylcellulose/polyacrylonitrile nanofibrous membranes (Ni@CMC/PAN NFMs). Owing to numerous O- and N-containing groups OTC has a strong tendency to complex with Ni2+ on the strips, inducing a color change from light green to yellow visible to the naked eye. The NFMs structural features, CMC functionalization process, and Ni2+ immobilization amount was carefully regulated to assure OTC detection whilst maintaining the inherent characteristics of NFMs. With the benefits of the large specific surface area (SSA) and small pore size of NFMs, the strips not only exhibited a rapid response (2 min), and low detection limit (5 nM) but also performed with good reversibility and selectivity concerning OTC detection over other antibiotics. The successful development of such enchanting nanofibrous materials may provide a new comprehension into the design and improvement of colorimetric strips.

A novel method to construct antimicrobial surface by decorating polyacrylonitrile nanofibrous membrane with nanoparticles

“…Polymeric membrane-based separation approach is the most useful disinfection strategy due to its self-standing, easy to package, and cost-effectiveness [7][8][9]. However, membranes for the disinfection of large volumes of water with high efficiency are still in the process of exploration [10,11].…”

“…Electrospun nanofibrous membranes (NFMs) have various typical structures, such as a high specific surface area, small pore size, tortuous porous structure, high porosity, unique mechanical properties, good flexibility, cost-effective production and easy to functionalization according to different application [14][15][16][17][18]. Electrospun polyacrylonitrile (PAN) NFMs offers promising properties, such as sufficient hydrophilicity, good mechanical strength, and low swelling rate [9,[19][20][21]. Nevertheless, aforementioned advantages of PAN NFMs also bring the unfavorable factor-membrane fouling [22].…”