Fasting Lipoprotein Lipase Protein Levels Can Predict a Postmeal Increment of Triglyceride Levels in Fasting Normohypertriglyceridemic Subjects

Tsuzaki, Kokoro; Kotani, Kazuhiko; Yamada, Kazunori; Sakane, Naoki

doi:10.1002/jcla.21869

Cited by 3 publications

(3 citation statements)

References 25 publications

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“…Tsuzaki et al reported supportive ndings. They found that fasting LPL mass levels may be useful as a predictor of increased postprandial triglycerides and that fasting LPL mass is a simple and easy-to-use marker in clinical practice [16]. On the other hand, no signi cant increase in LPL activity was found during chylomicron and VLDL overload after different kinds of food intake [17].…”

Section: Discussionmentioning

confidence: 99%

“…Missense mutations that interfere with LPL-GPIHBP1 interactions profoundly impair intravascular triglyceride processing, resulting in severe hypertriglyceridemia [14,15]. Fasting LPL mass levels may be useful as a predictor of postprandial triglyceride increases in fasting normotriglyceridemic subjects, and fasting LPL mass is a simple easy-to-use marker that can be applied in clinical practice [16]. On the other hand, no signi cant increase in LPL activity was found during chylomicron and very low-density lipoprotein (VLDL) overload after different kinds of food intake [17].…”

Section: Introductionmentioning

confidence: 99%

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Attenuation of Lipid Metabolism by Novel Pleiotropic Effects of Konjac Glucomannan

Kimura

Yoshida

Tsunekawa

et al. 2020

Preprint

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Background: Recently, we showed that konjac glucomannan (KGM) inhibited rice gruel-induced postprandial elevation of plasma glucose and insulin. To extend that research, we investigated the effects of adding KGM to rice gruel on pre- and postprandial circulating lipoprotein lipase (LPL), glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1), and triglyceride concentrations. Methods: Twenty-four Japanese male subjects without diabetes or gastrointestinal diseases (aged 46–56 years) were included. Subjects received rice gruel containing 0% or 0.8% of KGM (0%G and 0.8%G, respectively). Blood samples were obtained at preload and 30, 60, and 120 min after receiving rice gruel with or without 0.8% KGM. LPL, GPIHBP1, and triglyceride concentrations in these samples were measured. Results: Circulating triglycerides were significantly reduced at 30 min and then returned to the fasting value in the subjects who received 0%G, whereas lower triglyceride levels were sustained in those who received 0.8%G. Although circulating levels of LPL and GPIHBP1 were significantly reduced for 0%G, they were increased for 0.8%G. We found a significant negative correlation between circulating levels of fasting LPL and triglycerides and a significant positive correlation between circulating levels of fasting LPL and GPIHBP1. A significant negative correlation between circulating levels of triglycerides at 120 min and fasting LPL was shown in the 0.8%G group, but not in the 0%G group. A significant positive correlation between circulating levels of LPL at 0 min and 120 min was shown in the 0%G and 0.8%G groups.Conclusions: The results demonstrated a novel pleiotropic effect of KGM. Supplementation of KGM powder in rice gruel sustained lower levels of triglycerides accompanying elevation of LPL and GPIHBP1, which attenuated lipid metabolism. Additionally, fasting LPL is a predictor of postprandial circulating levels of LPL.Trial registration: UMIN registration number: UMIN000025950; registered at February 1st. 2017; https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000029247

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Attenuation of Lipid Metabolism by Novel Pleiotropic Effects of Konjac Glucomannan

Kimura

Yoshida

Tsunekawa

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Missense mutations that interfere with LPL–GPIHBP1 interactions profoundly impair intravascular TG processing, resulting in severe hypertriglyceridemia [ 14 , 15 ]. As it is a simple and easy-to-use marker that can be applied in clinical practice, fasting LPL mass may prove useful in predicting postprandial TG elevation in fasting individuals with normal TG levels [ 16 ]. Alternatively, no significant increase in LPL activity was found during chylomicron, and very low-density lipoprotein (VLDL) overload after eating different kinds of food [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Konjac Glucomannan Attenuated Triglyceride Metabolism during Rice Gruel Tolerance Test

Kimura

Yoshida

et al. 2021

Nutrients

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In a recent study, we showed that konjac glucomannan (KGM) inhibits rice gruel-induced postprandial increases in plasma glucose and insulin levels. To extend this research, we investigated the effects of KGM addition to rice gruel on pre- and postprandial concentrations of circulating lipoprotein lipase (LPL), glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1), hepatic triglyceride lipase (HTGL), free fatty acids (FFA), and triglycerides (TG). A total of 13 Japanese men, without diabetes, dyslipidemia, or gastrointestinal diseases, interchangeably ingested rice gruel containing no KGM (0%G), rice gruel supplemented with 0.4% KGM (0.4%G), and rice gruel supplemented with 0.8% KGM (0.8%G), every Sunday for 3 weeks. Blood samples were obtained at baseline and at 30, 60, and 120 min after ingestion to measure the abovementioned lipid parameters. Lipid parameters showed small, but significant, changes. Significant reductions were found in circulating FFA levels among all participants. Circulating TG levels significantly declined at 30 min and then remained nearly constant in the 0.8%G group but exhibited no significant difference in the 0%G and 0.4%G groups. Although circulating levels of LPL and GPIHBP1 significantly decreased in the 0%G and 0.4%G groups, they increased at 120 min in the 0.8%G group. Participants in the 0%G and 0.4%G groups showed significant decreases in circulating HTGL levels, which was not observed in the 0.8%G group. Our results demonstrate the novel pleiotropic effects of KGM. Supplementation of rice gruel with KGM powder led to TG reduction accompanied by LPL and GPIHBP1 elevation and HTGL stabilization, thereby attenuating TG metabolism.

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Adipose Tissue LPL Methylation is Associated with Triglyceride Concentrations in the Metabolic Syndrome

et al. 2018

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Fasting Lipoprotein Lipase Protein Levels Can Predict a Postmeal Increment of Triglyceride Levels in Fasting Normohypertriglyceridemic Subjects

Abstract: Fasting LPL levels may be useful to predict postprandial TG increment in this population.

Cited by 3 publications

References 25 publications

Attenuation of Lipid Metabolism by Novel Pleiotropic Effects of Konjac Glucomannan

Attenuation of Lipid Metabolism by Novel Pleiotropic Effects of Konjac Glucomannan

Konjac Glucomannan Attenuated Triglyceride Metabolism during Rice Gruel Tolerance Test

Adipose Tissue LPL Methylation is Associated with Triglyceride Concentrations in the Metabolic Syndrome

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