Konjac Glucomannan Attenuated Triglyceride Metabolism during Rice Gruel Tolerance Test

Abstract

In a recent study, we showed that konjac glucomannan (KGM) inhibits rice gruel-induced postprandial increases in plasma glucose and insulin levels. To extend this research, we investigated the effects of KGM addition to rice gruel on pre- and postprandial concentrations of circulating lipoprotein lipase (LPL), glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1), hepatic triglyceride lipase (HTGL), free fatty acids (FFA), and triglycerides (TG). A total of 13 Japanese men, without diabetes, dyslipidemia, or gastrointestinal diseases, interchangeably ingested rice gruel containing no KGM (0%G), rice gruel supplemented with 0.4% KGM (0.4%G), and rice gruel supplemented with 0.8% KGM (0.8%G), every Sunday for 3 weeks. Blood samples were obtained at baseline and at 30, 60, and 120 min after ingestion to measure the abovementioned lipid parameters. Lipid parameters showed small, but significant, changes. Significant reductions were found in circulating FFA levels among all participants. Circulating TG levels significantly declined at 30 min and then remained nearly constant in the 0.8%G group but exhibited no significant difference in the 0%G and 0.4%G groups. Although circulating levels of LPL and GPIHBP1 significantly decreased in the 0%G and 0.4%G groups, they increased at 120 min in the 0.8%G group. Participants in the 0%G and 0.4%G groups showed significant decreases in circulating HTGL levels, which was not observed in the 0.8%G group. Our results demonstrate the novel pleiotropic effects of KGM. Supplementation of rice gruel with KGM powder led to TG reduction accompanied by LPL and GPIHBP1 elevation and HTGL stabilization, thereby attenuating TG metabolism.

A Newly Synbiotic Combination Alleviates Obesity by Modulating the Gut Microbiota–Fat Axis and Inhibiting the Hepatic TLR4/NF‐κB Signaling Pathway

“…[ 4,13–15 ] In addition, recent studies have revealed that prebiotics konjac glucomannan oligosaccharides (KGMO) helps regulate the gut microbiota and enhances mucosal barrier function and anti‐inflammatory status. [ 16–18 ]…”

“…[4,[13][14][15] In addition, recent studies have revealed that prebiotics konjac glucomannan oligosaccharides (KGMO) helps regulate the gut microbiota and enhances mucosal barrier function and antiinflammatory status. [16][17][18] With this in mind, we creatively prepared a newly synbiotic combination consisting of two probiotic strains (L. acidophilus and B. infantis), along with one prebiotic KGMO. Consequently, the study aimed to investigate the anti-obesity effects of synbiotic combination, as well as its roles in regulating the intestinal flora maintaining intestinal integrity, alleviate inflammation, and regulating lipid metabolism the mouse model of high fat diet (HFD)induced obesity.…”

Enhancing Metabolic Parameters: The Impact of Porang Glucomannan on Body Weight, Intraperitoneal Fat, Fasting Blood Glucose, and GLUT-4 Levels in Rats Fed a High-Fat and High-Carbohydrate Diet

“…5 Management of metabolic syndrome typically involves lifestyle modifications and pharmacotherapeutic drugs to address hyperglycemia, hypertension, and dyslipidemia. 6 Another approach to reducing the risk of metabolic syndrome is using porang glucomannan. However, research on the effects of porang glucomannan on metabolic syndrome is still limited, necessitating further research to validate its potential impact on body weight, intraperitoneal fat, fasting blood glucose, and GLUT-4 levels.…”

“…These soluble and thick characteristics challenge digestive enzymes, resulting in a slower gastric emptying rate and inhibiting fat absorption in the small intestine. 6 This makes porang glucomannan an effective component for weight management. Porang glucomannan, also known as Amorphophallus muelleri Blume, is an indigenous tuber commonly found in Indonesia.…”