2007
DOI: 10.1016/j.chemosphere.2006.05.051
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Fate of 5-fluorouracil, doxorubicin, epirubicin, and daunorubicin in hospital wastewater and their elimination by activated sludge and treatment in a membrane-bio-reactor system

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Cited by 214 publications
(101 citation statements)
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“…An improved method similar to OECD 309 used by Yu et al [48] demonstrated an approximately 50% biodegradation of 5-fluorouracil. This finding was further supported by Mahnik et al [43] adopting a method using membrane bioreactor and radio-labelled substances. In addition, as a prodrug, capecitabine can be enzymatically converted to 5-fluorouracil in the cell.…”
Section: Antimetabolites (Folate Acid Analogues and Purines): Methotrmentioning
confidence: 52%
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“…An improved method similar to OECD 309 used by Yu et al [48] demonstrated an approximately 50% biodegradation of 5-fluorouracil. This finding was further supported by Mahnik et al [43] adopting a method using membrane bioreactor and radio-labelled substances. In addition, as a prodrug, capecitabine can be enzymatically converted to 5-fluorouracil in the cell.…”
Section: Antimetabolites (Folate Acid Analogues and Purines): Methotrmentioning
confidence: 52%
“…However, when they are treated with H 2 O 2 or K 2 S 2 O 8 , the generation of hydroxyl radical and sulfate radical anion significantly accelerated the removal rate of cytarabine. Other methods such as membrane bioreactor systems [43] were also tested and proved to be effective to eliminate 5-fluorouracil in hospital wastewater.…”
Section: Nonclassical Alkylating Agents (Platinum Compounds): Cisplatmentioning
confidence: 99%
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“…Moreover, by light radiation, the hydrogen peroxide molecule undergoes a cleavage to produce O 2 gas (2). According to the photocatalytic mechanism, the O 2 gas reacts with conduction band electrons through several steps and generates • OH radicals (3)(4)(5). …”
Section: Photocatalytic Degradation Investigation Of Doxmentioning
confidence: 99%
“…DOX is applied in the treatment of various cancers such as bladder, stomach, breast, ovaries, lung, thyroid, multiple myeloma, soft tissue sarcoma, leukemia, Hodgkin's lymphoma and other kinds of cancers [2]. In the pharmaceutical industry, this drug can be excreted into the environment through production excretion, formulation sites, as well as un-metabolised substances or their metabolites in urine or stool of the direct consumers of the [3]. So due to the high toxicity of this drug, it should be completely degraded before entering the environment.…”
Section: Introductionmentioning
confidence: 99%