Fate of Carbofuran in Laying Hens1

Goetting, V., Lee, K. A., Tell, L. A. Pharmacokinetics of veterinary drugs in laying hens and residues in eggs: a review of the literature. J. vet. Pharmacol. Therap.34, 521–556. Poultry treated with pharmaceutical products can produce eggs contaminated with drug residues. Such residues could pose a risk to consumer health. The following is a review of the information available in the literature regarding drug pharmacokinetics in laying hens, and the deposition of drugs into eggs of poultry species, primarily chickens. The available data suggest that, when administered to laying hens, a wide variety of drugs leave detectable residues in eggs laid days to weeks after the cessation of treatment.

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“…Orally administered carbamates are well absorbed from the GI tract in chickens and widely distributed to tissues (Hicks et al. , 1970).…”

Section: Overview Of the Drug Classesmentioning

confidence: 99%

Pharmacokinetics of veterinary drugs in laying hens and residues in eggs: a review of the literature

Goetting¹,

Lee²,

Tell³

2011

Journal of Veterinary Pharmacology and Therapeutics

152

135

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“…Radioactive measurements were accomplished on a Packard Tri-Carb Model 3380/544 liquid scintillation counter. The scintillation mixture and the details of counting liquid and solid samples were the same as described in a similar study with carbofuran (Hicks et al, 1970). The blood was radioassayed by oxygen combustion techniques, as were all solids, after 1 g of blood was evaporated to dryness in a bag made from dialysis tubing (Andrawes et al, 1967).…”

Section: Methodsmentioning

confidence: 99%

Metabolism of aldicarb pesticide in laying hens

Hicks¹,

Dorough²,

Mehendale³

1972

J. Agric. Food Chem.

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“…Most animals appear to metabolize and excrete up to 90% of administered carbofuran in 2 days (Dorough, 1968;Hicks et al, 1970;Krishna and Casida, 1966;Leeling and Casida, 1966;. report that Estigmene acrea, the salt marsh caterpillar, had excreted 88% of the total administered carbofuran (found as polar conjugates) in the feces after 4 days.…”

Section: T H Imentioning

confidence: 99%