Fate of nano-phytosomes containing bioactive compounds of Echinacea extract in an acidic food beverage

Molaveisi, Mohammad; Noghabi, Mostafa Shahidi; Parastouei, Karim; Taheri, Ramezan Ali

doi:10.1016/j.foostr.2021.100177

Cited by 35 publications

(8 citation statements)

References 35 publications

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“…Echinacea purpurea L. is a perennial medicinal plant of the Asteraceae family, native to America, and is the most widely cultivated medicinal plant of this species. This plant gained its reputation due to its medicinal and phytochemical compounds, being used in the treatment of skin conditions, chronic arthritis, intestinal pain, convulsions, and cancer [ 10 ], and at the same time representing a valuable source of antioxidants, which can be formulated for oral consumption [ 11 ]. Recently, an Echinacea ethanol extract encapsulated in chitosan-silica nanoparticles was proven to have a protective role against meniscal/ligamentous-injury-induced osteoarthritis in the obese rats [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Phytosynthesis of Biological Active Silver Nanoparticles Using Echinacea purpurea L. Extracts

et al. 2022

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With their phytoconstituents acting as reducing and capping agents, natural extracts can be considered a viable alternative for the obtaining of metallic nanoparticles. The properties of phytosynthesized nanoparticles are dependent upon size and morphology, which, in turn, can be tailored by adjusting different parameters of the phytosynthesis process (such as the extracts’ composition). In the present study, we aimed to evaluate, for the first time in the literature, the influence of the extraction method and extract concentration on the morphological and biological properties (antioxidant and antibacterial activity) of silver nanoparticles phytosynthesized using Echinacea pupurea L. extracts. The obtained results revealed that the use of the low-concentration Echinacea hydro-alcoholic extract obtained via classical temperature extraction led to the development of nanoparticles with the smallest dimensions (less than 10 nm), compared with the use of extracts obtained with higher concentrations and the extract obtained via the microwave method. The developed nanomaterials exhibited enhanced antioxidant effects (determined via the DPPH assay) and antimicrobial properties (against Escherichia coli and Candida albicans), compared with the parent extracts.

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Section: Introductionmentioning

confidence: 99%

Phytosynthesis of Biological Active Silver Nanoparticles Using Echinacea purpurea L. Extracts

et al. 2022

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“…Meanwhile, the soy lecithin spectrum showed the presence of C=O, P-O-C, and C-O signals characteristic of the signals of phospholipid compounds consisting of fatty acid unit (with ester groups) phosphates joined together [33]. The interaction between metabolite compounds and soy lecithin was thought to be a hydrogen interaction characterized by a broader O-H signal (3419.89 cm −1 ) in the spectrum of phytosome F1 [18,34].…”

Section: Discussionmentioning

confidence: 99%

“…Phytosomes are used to incorporate plant extracts or polar phytoconstituents into phospholipids to produce lipid-compatible molecular complexes. The phytosome form has been used to enhance its bioavailability, remarkably increasing the release of compounds in the gut, maintaining bioactivity in long-term storage, or preventing degradation and increasing penetration in the skin [17][18][19]. In the manufacture of phytosomes, lecithin derived from soybeans was used.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity, Sun Protection Activity, and Phytochemical Profile of Ethanolic Extracts of Daemonorops acehensis Resin and Its Phytosomes

et al. 2022

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Daemonorops (Indonesian: jernang) resin is one of Indonesia’s leading non-timber forest products and can be developed as a source of natural antioxidants and sun protection. This study aimed to select promising solvents for extracting a Daemonorops acehensis resin and phytosome formulation with high antioxidant capacities and sun protection factor (SPF) values. Jernang resin was extracted using a water–ethanol mixture in five different ratios. The promising extract was then mixed with soy lecithin in three different formulations. A promising extract and phytosome were then selected based on their antioxidant capacities and sun protection factor (SPF) values. A liquid chromatography mass spectrometry/mass spectrometry (LC–MS/MS) analysis was also performed on five extracts to identify the components in the extracts that might be responsible for the biological activity. The results showed that the ethanol solvent variation and phytosome formulation influenced the antioxidant capacity and SPF value. A hundred-percent ethanolic extract and F1 phytosome exhibited the highest antioxidant capacities and SPF values. A qualitative analysis revealed the various classes of compounds in the extract and phytosome. A flavylium chromophore, dracorhodin, dominated the resin extract and was presumed to be the marker compound responsible for their antioxidant capabilities and SPF values. These findings are important for manufacturing sunscreens containing active compounds of bioactive natural resins.

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“…Phosphatidylcholine Abutilon indicum and Piper longum Hepatoprotective effect [191] Phosphatidylcholine Annona muricata L. aqueous extract Treatment of major depressive disorders [192] Milk phospholipids Ascorbic acid and α-tocopherol Antioxidative [193] Phosphatidylcholine Berberine Diabetes treatment [194] Phosphatidylcholine Chicoric acid and chlorogenic acid from the Echinacea plant Antioxidant activity [195] Egg phospholipid Chrysin Diabetes treatment [196,197] Lecithin Diosgenin Lung cancer treatment [198] Phosphatidylcholine Diosmin Vascular protection activity [199] Phosphatidylcholine and piperine Domperidone Anti-emetic effect [200] Lecithin Ethanolic extract of leaves of Bombax ceiba Hepatoprotective effect [201] Lipoid ® S45 Flavonoids from Citrullus colocynthis, mormodica balsamina l. and mormodica dioica roxb.…”

Section: Cargo Application Referencementioning

confidence: 99%

Lipid-Based Nanovesicular Drug Delivery Systems

et al. 2021

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In designing a new drug, considering the preferred route of administration, various requirements must be fulfilled. Active molecules pharmacokinetics should be reliable with a valuable drug profile as well as well-tolerated. Over the past 20 years, nanotechnologies have provided alternative and complementary solutions to those of an exclusively pharmaceutical chemical nature since scientists and clinicians invested in the optimization of materials and methods capable of regulating effective drug delivery at the nanometer scale. Among the many drug delivery carriers, lipid nano vesicular ones successfully support clinical candidates approaching such problems as insolubility, biodegradation, and difficulty in overcoming the skin and biological barriers such as the blood–brain one. In this review, the authors discussed the structure, the biochemical composition, and the drug delivery applications of lipid nanovesicular carriers, namely, niosomes, proniosomes, ethosomes, transferosomes, pharmacosomes, ufasomes, phytosomes, catanionic vesicles, and extracellular vesicles.

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Fate of nano-phytosomes containing bioactive compounds of Echinacea extract in an acidic food beverage

Cited by 35 publications

References 35 publications

Phytosynthesis of Biological Active Silver Nanoparticles Using Echinacea purpurea L. Extracts

Phytosynthesis of Biological Active Silver Nanoparticles Using Echinacea purpurea L. Extracts

Antioxidant Activity, Sun Protection Activity, and Phytochemical Profile of Ethanolic Extracts of Daemonorops acehensis Resin and Its Phytosomes

Lipid-Based Nanovesicular Drug Delivery Systems

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