Fatores prognósticos no carcinoma espinocelular de cavidade oral

Abstract

Researchers have been looking for factors that can influence the prognosis of oral cancer, because its outcome is highly uncertain. Aim: To evaluate variables that can impact the survival rate of patients with squamous-cell carcinoma of the oral cavity. Material and Methods: Data analysis of 45 patients from January, 2001 to January, 2006. Survival rate curves have been estimated using the KaplanMeier method and they have been compared through the log-rank test and the Cox regression standard. Study design: Retrospective analysis. Results: Total five-year survival rate was of 39% fpr these patients. Only the neck metastases (p=0.017), postoperative radiotherapy (p=0.056) and diseased margin(p=0.004) variables had statistic relevance. Survival rate was lower in patients with neck metastases, margins involved and those who underwent postoperative radiotherapy, in other words, those with the most aggressive tumors. After adjustment, radiotherapy did not prove to be statistically relevant. It is likely that the survival rate of 39% was due to the high number of patients with metastasis (52%) and because the samples were mostly of tongue and mouth floor diseases (82%), which are the hardest to control. Conclusion: Neck metastases and diseased margins of oral cavity carcinomas are the prognostic factors that can most impact the survival rate.

O perfil epidemiológico pode influenciar as características clínicas e malignas dos carcinomas orais e orofaríngeos?

“…Only 9.5% had not been exposed to tobacco, as ob-served in other studies. 8,14,17,25 There was exposure to alcohol consumption by 64.3% of patients, similar to that found by other authors. 8,14,19 There was an association between alcohol exposure and clinical stage of the lesion at diagnosis (p<0.05) in the present study.…”

Vivências da formação de profissionais de saúde: Aventuras e percursos de educação pelo trabalho

“…Porém, no contexto brasileiro, o câncer de cavidade oral continua com um prognóstico desfavorável, com altas taxas de mortalidade (Martínez-CorteZ et al, 2011; Scheufen et al, 2011), e diagnóstico ainda tardio Figueiredo, 2012). A sobrevida continua baixa, cerca de 48% (sobrevida global) e 57% (sobrevida específica para a doença) em 5 anos (MONTORO et al, 2008).…”

Regeneração Óssea Guiada Após Extração De Dentes Com Barreira De Polipropileno (Bone Heal): Relato De Caso

“…A maconha e o papilomavírus humano (HPV) têm sido estudados como possíveis agentes carcinogênicos, porém os mecanismos envolvidos são pouco conhecidos até o momento(SASSI, et al 2009). Vinson e acometido por CEC não apresentava hábito de tabagismo ou etilismo.No trabalho deMontoro (2008) não foi detectado nenhum fator relacionado ao paciente dentre os estudados que tenha influenciado a sobrevida, pois idade, sexo, tabagismo e etilismo não tiveram significância estatística. Na literatura também não há consenso sobre a influência desses fatores.Atualmente para o diagnóstico de Carcinoma Espinocelular emprega-se algunos métodos complementares que podem incluir biópsia, testes de laboratório,…”