Fatty acid compositions in local sea cucumber,

Fredalina, B.D.; Ridzwan, B.H.; Abidin, Asroful; Kaswandi, M.A.; Zaiton, H.; Zali, I.; Kittakoop, Prasat; Jais, Abdul Manan Mat

doi:10.1016/s0306-3623(98)00253-5

Cited by 122 publications

(48 citation statements)

References 11 publications

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“…Wound healing was significantly better when compared to gold standard for minor wound treatment like flavine. This effect could be due to the large number of therapeutic properties of sea cucumber, which includes antioxidant (Althunibat et al 2009), antimicrobial (Kumar et al 2007), anti-inflammatory (Bordbr et al 2011), antiviral and other wound healing properties (Aydin et al 2011;Fredalina et al 1999).…”

Section: Discussionmentioning

confidence: 99%

“…The majority of sea cucumber antioxidant property was contributed by its hydrophilic components. According to Fredalina et al (1999), fatty acid compound in Stichopus chloronotus plays an important role in wound healing process. The study also demonstrated that the fatty acids contained in the aqueous extract of Stichopus chloronotus are palmitic acid 2.2%, stearic acid 9.71%, linolenic acid 12.59%, oleic acid 7.50%, eicosapentaenoic acid 27.84, decosahexaenoic acid 57.55% & Arachidonic acid 1.46%.…”

Section: Discussionmentioning

confidence: 99%

“…In another study using a different species of sea cucumber, Holothuria polii, both the methanolic and aqueous extracts showed antifungal activities. Based on these studies, it was concluded that both the aqueous and methanolic extracts of sea cucumber contained antimicrobial components (Fredalina et al 1999;Ismail et al 2008). The antimicrobial potential of sea cucumber extract can also be ascribed to the presence of steroidal sapogenins antimicrobial agents (Abraham et al 2002).…”

Section: Discussionmentioning

confidence: 99%

“…The sea cucumber body was then dried in oven at 60°C until no change of mass. The method used is according to Fredalina et al (1999) with minor modification. The dried sea cucumber was cut into smaller pieces and homogenized without water.…”

Section: Aqueous Extraction Of Stichopus Chloronotusmentioning

confidence: 99%

“…It is the second most common species found in Malaysia (Choo 2008). It has been reported that Stichopus chloronotus has composition of fatty acid which is important and play a key role in wound healing process (Fredalina et al 1999). Therefore, we conducted a scientific evaluation of optimum dose chloronotus on the healing of wounds in rat model.…”

Section: Introductionmentioning

confidence: 99%

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Optimum Dose of Sea Cucumber (Stichopus Chloronotus) Extract for Wound Healing

Mazliadiyana¹,

As²,

Mohamed³

2017

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ABSTRAK ABSTRACTIn Malaysia, sea cucumber is also known as Gamat. Among the Malays, Gamat is frequently used as a traditional or folk medicine to relieve pain, to treat wounds and burns. It is also used as a tonic to provide extra energy. Stichopus chloronotus is one of the species of sea cucumber which is found in Malaysia. An experimental study was carried out to determine the optimum dose of aqueous extract of Stichopus et al. 2011). Stichopus chloronotus (Black Knobby or green fish) is one of the common species that can be found around indo-Pacific Ocean such as Taiwan, Singapore, Thailand and Malaysia. It is the second most common species found in Malaysia (Choo 2008). It has been reported that Stichopus chloronotus has composition of fatty acid which is important and play a key role in wound healing process (Fredalina et al. 1999). Therefore, we conducted a scientific evaluation of optimum dose chloronotus on the healing of wounds in rat model. A series of concentrations 0.1%, 0.5% and 1% aqueous extract emulsifying ointment mixed with Stichopus chloronotus was applied once a day for 10 days on the excision wound model. Changes in the wound area were measured using a caliper and photographs were taken on day 1, 3, 6, 8 and 10 after the wound creation. The wound reduction rate and macroscopic observation were evaluated to determine the optimum dose concentration. Results demonstrated that percentage of wound reduction and macroscopic observation of 0.5% aqueous extract Stichopus chloronotus emulsifying ointment mixed group was significantly higher than the other groups from day 6 following wound creation. In conclusion, 0.5% aqueous extract of Stichopus chloronotus emulsifying ointment mixture demonstrated the best dose for wound healing in a rat model.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Aqueous Extraction Of Stichopus Chloronotusmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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