Fatty-acid-derived ester-urethane macromonomers synthesized using bismuth and zinc catalysts

Injectable and photocurable macromonomers synthesized using a novel heterometallic magnesium-titanium metal-organic catalyst

“…Nuclear magnetic resonance spectroscopy ( 1 H and 13 C NMR) was performed to confirm the chemical structure of the obtained telechelic macromonomers. Spectra were recorded using Bruker DPX HD-400 MHz at 25 °C.…”

“…Synthesis of telechelic macromonomers was performed in two steps based on our previous work [13] and the reaction scheme is presented in Figure 2. In the first step, 50 mL of EtOAc in a 250 mL roundbottom flask was degassed with three argon/vacuum cycles.…”

“…Photocuring of the obtained macromonomers was performed according to the procedure thoroughly described in our previous work [13]. Briefly, the obtained telechelic macromonomers were mixed with a 2% w/w solution of Omnirad 819 photoinitiator in EtOAc.…”

“…Building upon our previous work, here we investigated synthesis of the telechelic macromonomers based on polyester polyol using magnesium-titanium (IV) butoxide as catalyst. We hypothesized that this heterometallic catalytic system would result in shorter reaction times than our previous work with bismuth and zinc-based homometallic catalysts [13], while at the same time the materials would remain non-toxic. Towards this aim, we examined chemical structure and physio-chemical properties of the obtained macromonomers and we performed the cytotoxicity screening to assess their usability in minimally invasive medical procedures.…”

“…In our previous work, we demonstrated that bismuth and zinc-based homometallic catalysts can be attractive, less toxic alternatives to DBTDL for the synthesis of photocurable ester-urethane macromonomers [13]. Here we aim to investigate heterometallic complexes, because may offer higher catalytic activity and greater selectivity, as compared to their homometallic analogues [14].…”